The use of web ontology languages and other semantic web tools in drug discovery

2010 ◽  
Vol 5 (5) ◽  
pp. 413-423 ◽  
Author(s):  
Huajun Chen ◽  
Guotong Xie
2019 ◽  
Vol 14 (5) ◽  
pp. 433-444 ◽  
Author(s):  
Samantha Kanza ◽  
Jeremy Graham Frey

Author(s):  
Komal Dhulekar ◽  
Madhuri Devrankar

Semantic web is a concept that enables better machine processing of information on the web, by structuring documents written for the web in such a way that they become understandable by machines. This can be used for creating more complex applications (intelligent browsers, more advanced web agents), etc. Semantic modeling languages like the Resource Description Framework (RDF) and topic maps employ XML syntax to achieve this objective. New tools exploit cross domain vocabularies to automatically extract and relate the meta information in a new context. Web Ontology languages like DAML+OIL extend RDF with richer modeling primitives and a provide a technological basis to enable the Semantic Web. The logic languages for Semantic Web are described (which build on the of RDF and ontology languages). They, together with digital signatures, enable a web of trust, which will have levels of trust for its resources and for the rights of access, and will enable generating proofs, for the actions and resources on the web.


Author(s):  
David Mendes ◽  
Irene Pimenta Rodrigues

The ISO/HL7 27931:2009 standard intends to establish a global interoperability framework for healthcare applications. However, being a messaging related protocol, it lacks a semantic foundation for interoperability at a machine treatable level intended through the Semantic Web. There is no alignment between the HL7 V2.xml message payloads and a meaning service like a suitable ontology. Careful application of Semantic Web tools and concepts can ease the path to the fundamental concept of Shared Semantics. In this chapter, the Semantic Web and Artificial Intelligence tools and techniques that allow aligned ontology population are presented and their applicability discussed. The authors present the coverage of HL7 RIM inadequacy for ontology mapping and how to circumvent it, NLP techniques for semi-automated ontology population, and the current trends about knowledge representation and reasoning that concur to the proposed achievement.


Author(s):  
Juan Li ◽  
Ranjana Sharma ◽  
Yan Bai

Drug discovery is a lengthy, expensive and difficult process. Indentifying and understanding the hidden relationships among drugs, genes, proteins, and diseases will expedite the process of drug discovery. In this paper, we propose an effective methodology to discover drug-related semantic relationships over large-scale distributed web data in medicine, pharmacology and biotechnology. By utilizing semantic web and distributed system technologies, we developed a novel hierarchical knowledge abstraction and an efficient relation discovery protocol. Our approach effectively facilitates the realization of the full potential of harnessing the collective power and utilization of the drug-related knowledge scattered over the Internet.


Author(s):  
Changqing Li ◽  
Tok W. Ling

This chapter introduces how to effectively organize ontology languages and ontologies and how to efficiently process semantic information based on ontologies. In this chapter we propose the hierarchies to organize ontology languages and ontologies. Based on the hierarchy of ontology languages, the ontology designers need not bear in mind which ontology language the primitives exactly come from, also we can automatically and seamlessly use the ontologies defined with different ontology languages in an integrated environment. Based on the hierarchy of ontologies, the conflicts in different ontologies are resolved, thus the semantics in different ontologies are clear without ambiguities. Also, these semantic-clear ontologies can be used to efficiently process the semantic information in Semantic Web and e-business.


Author(s):  
Daniel Oberle ◽  
Christof Bornhovd ◽  
Michael Altenhofen

This chapter discusses scalability problems and solutions to services-based ubiquitous computing applications in real time enterprises. The scalability problems are (1) identifying relevant services for deployment, (2) verifying a composition by a logical rule framework, and (3) enabling the mapping of required services to the “best” available device. We argue that ontologies can help to counter these challenges. Subsequently, we provide a detailed introduction to ontologies. We focus on the ontology languages emerging from the corresponding W3C Semantic Web activity. The W3C recommendations have a high impact on future tools and the interoperability of ontology-based applications. We contrast the pros and cons of ontologies at a general level and demonstrate the benefits and challenges in our concrete smart items middleware.


2011 ◽  
pp. 96-109 ◽  
Author(s):  
G. Antoniou

Web ontology languages will be the main carriers of the information that we will want to share and integrate. The aim of this chapter is to give a general introduction to some of the ontology languages that play a prominent role on the Semantic Web. In particular, it will explain the role of ontologies on the Web and in ICT, review the current standards of RDFS and OWL, and discuss open issues for further developments.


2015 ◽  
pp. 57-88
Author(s):  
Chuanrong Zhang ◽  
Tian Zhao ◽  
Weidong Li

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