Association study of IL2RA and CTLA4 Gene Variants with Type I Diabetes Mellitus in children in the northwest of Iran Association study of IL2RA and CTLA4 gene variants with type-1 diabetes mellitus in children in the northwest of Iran

This study considers the efficiency of use of a combined drug based on beta-sitosterol and polyprenyl phosphates in dogs with type I diabetes mellitus complicated by hyperlipidemia. It was shown that after 1 month of the therapy, there was a significant decrease of the level of cholesterol, triglycerides and glucose vs. control animals. After 2 months of the therapy, in the control group the level of cholesterol and triglycerides was at the upper limit of the norm, which can lead to an exacerbation of the disease in future.

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The codon 17 polymorphism of the CTLA4 gene in type 1 diabetes mellitus in the Baghdad population

Journal of Medical Genetics and Genomics ◽

10.5897/jmgg2013.0073 ◽

2014 ◽

Vol 6 (1) ◽

pp. 1-5

Author(s):

S. H. Ahmed Najwa

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Ctla4 Gene

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Type I Diabetes Mellitus

10.2310/im.4017 ◽

2019 ◽

Author(s):

Joseph I. Wolfsdorf ◽

Katharine Garvey

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Type 1 Diabetes Mellitus ◽

Diabetic Ketoacidosis ◽

Autoimmune Diabetes ◽

Type I ◽

Insulin Deficiency ◽

Glucose Levels

Type 1 diabetes mellitus is characterized by severe insulin deficiency, making patients dependent on exogenous insulin replacement for survival. These patients can experience life-threatening events when their glucose levels are significantly abnormal. Type 1 diabetes accounts for 5 to 10% of all diabetes cases, with type 2 accounting for most of the remainder. This review details the pathophysiology, stabilization and assessment, diagnosis and treatment, disposition and outcomes of patients with Type 1 diabetes mellitus. Figures show the opposing actions of insulin and glucagon on substrate flow and plasma levels; plasma glucose, insulin and C-peptide levels throughout the day; the structure of human proinsulin; current view of the pathogenesis of Type 1 autoimmune diabetes mellitus; pathways that lead from insulin deficiency to the major clinical manifestations of Type 1 diabetes mellitus; relationship between hemoglobin A1c values at the end of a 3-month period and calculated average glucose levels during the 3-month period; different combinations of various insulin preparations used to establish glycemic control; and basal-bolus and insulin pump regimens. Tables list the etiologic classification of Type 1 diabetes mellitus, typical laboratory findings and monitoring in diabetic ketoacidosis, criteria for the diagnosis of Type 1 diabetes, clinical goals of Type 1 diabetes treatment, and insulin preparations. This review contains 10 figures, 9 tables, and 40 references. Keywords: Type 1 diabetes mellitus, optimal glycemic control, hypoglycemia, hyperglycemia, polyuria, polydipsia, polyphagia, HbA1c, medical nutrition therapy, Diabetic Ketoacidosis

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Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus

Frontiers in Immunology ◽

10.3389/fimmu.2020.576903 ◽

2020 ◽

Vol 11 ◽

Author(s):

Lan Yang ◽

Xiao Han ◽

Caiyan Zhang ◽

Chengjun Sun ◽

Saihua Huang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Type I Interferon ◽

Type I

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Association study of polymorphisms in SOCS family genes with type 1 diabetes mellitus

International Journal of Immunogenetics ◽

10.1111/j.1744-313x.2006.00563.x ◽

2006 ◽

Vol 33 (1) ◽

pp. 7-10 ◽

Cited By ~ 4

Author(s):

R. Ni ◽

K. Ihara ◽

K. Miyako ◽

M. Takemoto ◽

M. Ishimura ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Association Study

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Association Study of Human MTH1 Gene Polymorphisms with Type 1 Diabetes Mellitus

Endocrine Journal ◽

10.1507/endocrj.51.493 ◽

2004 ◽

Vol 51 (5) ◽

pp. 493-498 ◽

Cited By ~ 7

Author(s):

Kenichi MIYAKO ◽

Hitoshi KOHNO ◽

Kenji IHARA ◽

Ryuichi KUROMARU ◽

Nobuo MATSUURA ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Association Study ◽

Gene Polymorphisms

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Thyroid auto immune antibodies in children with Type-I Diabetes mellitus in relation to diabetes control

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.35.4.192 ◽

2019 ◽

Vol 35 (4) ◽

Author(s):

Muneera Fadhil Ridha ◽

Munib Ahmed Al Zubaidi

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Type I Diabetes ◽

Thyroid Autoimmunity ◽

Diabetic Control ◽

Type I Diabetes Mellitus ◽

Type I ◽

Thyroid Antibodies

Background & Objective: As an autoimmune disease, Type-1 diabetes mellitus (DM) may be associated with other autoimmune disorders, the presence of thyroid antibodies could be negatively impact the diabetic control. Our objective was to investigate thyroid autoimmunity in a cohort of children and adolescents with Type-1 diabetes and the Influence of the presence of thyroid autoimmune abnormalities on the control of diabetes in group of Iraqi pediatric patients with Type-I D.M. Methods: This study was conducted at the Medical City Complex, Children Welfare Hospital, Baghdad, Iraq. This study was carried out from the first of January 2016 till the end of September 2017. Data were analyzed from 150 patients with Type-1 diabetes, aged 1–18 years who were treated and are coming for regular follow up in the diabetic clinic. Thyroid functions tests, Antibodies to thyroglobulin (anti-TG) and thyroperoxidase (anti-TPO) were measured, documented and correlated with diabetic control according to glycated haemoglobin (HbA1c) level. Results: In the total of 150 patients, positive Antibodies to thyroglobulin (anti TG) were more in ≤3 years duration group of Diabetes mellitus( DM) and negative anti TG was less in the >3 years duration of DM group with statistically significant results (p=0.043), Regarding the distribution of thyroid antibodies (AB) according to HbA1c group, there was progressive positive anti thyroperoxidase (anti TPO) titer with glycemic status, good glycemic control had the lowest positive anti TPO titer and poor glycemic control group had the highest positive anti TPO titer and the result was statistically significant (p=0.048). Conclusions: Thyroid autoimmunity may be associated with poor diabetic control and elevated TSH levels, indicating subclinical hypothyroidism that my affect the diabetic control. doi: https://doi.org/10.12669/pjms.35.4.192 How to cite this:Ridha MF, Al-Zubaidi MA. Thyroid auto immune antibodies in children with type I Diabetes mellitus in relation to diabetes control. Pak J Med Sci. 2019;35(4):---------. doi: https://doi.org/10.12669/pjms.35.4.192 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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