The Anti-oxidant and Anti-inflammatory Properties of Cerium Oxide Nanoparticles Synthesized Using Origanum majorana L. Leaf Extract

Introduction: Free radicals have singlet electron in their outer layer rendering them high reactivity against biomolecules (i.e., DNA, carbohydrates, proteins, and lipids). Oxidative stress is created when the production of free radicals exceeds their removal by antioxidant systems and is involved in the pathogenesis of several diseases such as diabetes, arthritis, inflammatory conditions, and various cancers. Regarding the therapeutic potential of nanoparticles (NPs) in human diseases, the purpose of this study was to synthesize cerium oxide NPs using Origanum majorana leaf extract. Methods: Cerium oxide nanoparticles (CeO2 -NPs) were synthesized using aqueous leaf extract of O. majorana. The sizes of NPs were characterized by a particle size analyzer. The antioxidant properties of the CeO2 -NPs were determined by Ferric-reducing antioxidant power (FRAP) assay. The anti-inflammatory effects of the NPs were also determined by measuring gene expressions of IL-1β and IL-10 using real-time polymerase chain reaction (PCR). Results: The CeO2 -NPs were successfully synthesized using O. majorana leaf extract. The results of FRAP assay showed that the anti-oxidant activities of CeO2 -NPs at concentrations of 50, 100, and 400 μg/mL were 75%, 77.1%, and 94.5%, respectively. Moreover, interleukin 10 (IL-10) gene expressions increased by 4.6 folds while the expression of IL-1β gene decreased by 0.75-fold in HUVECs. Conclusion: The CeO2 -NPs synthesized using the aqueous extract of O. majorana demonstrated antioxidant and anti-inflammatory properties. Therefore, these NPs can be used as potential therapeutic agents in medicine.

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Size- and defect-controlled anti-oxidant enzyme mimetic and radical scavenging properties of cerium oxide nanoparticles

New Journal of Chemistry ◽

10.1039/c8nj04435j ◽

2018 ◽

Vol 42 (23) ◽

pp. 18810-18823 ◽

Cited By ~ 12

Author(s):

G. Vinothkumar ◽

P. Arunkumar ◽

Arun Mahesh ◽

Arunkumar Dhayalan ◽

K. Suresh Babu

Keyword(s):

Enzymatic Activity ◽

Cerium Oxide ◽

Oxidase Activity ◽

Radical Scavenging ◽

Cerium Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Selective Activation ◽

Enzyme Mimetic ◽

Anti Oxidant ◽

Radical Scavenging Properties

Improved enzymatic activity and concentration-dependent selective activation of peroxidase and oxidase activity of combustion-synthesized nanoceria.

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Cerium oxide nanoparticles and their importance in cell signaling pathways for predicting cellular behavior

Nanomedicine ◽

10.2217/nnm-2020-0104 ◽

2020 ◽

Vol 15 (17) ◽

pp. 1709-1718

Author(s):

Atefeh Pesaraklou ◽

Maryam M Matin

Keyword(s):

Signaling Pathways ◽

Cerium Oxide ◽

Cellular Responses ◽

Cerium Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Signaling Proteins ◽

Cellular Behavior ◽

Anti Oxidant ◽

Different Response ◽

Cell Signaling Pathways

Cerium oxide nanoparticles (CeO2-NPs) have prolifically attracted immense interest of researchers due to their prominent anti-oxidant nature. However, these characteristics are accompanied by some ambiguities in other studies reporting their oxidant and toxic properties. In this regard previous literature has pointed to the importance of the NPs morphology and environmental conditions as well as biomolecules that induce a different response by initiating a cascade of activities. Therefore, due to the fact that signaling proteins are key mediators in cellular responses, the cognizance of the CeO2-NP-targeted signaling pathways could facilitate predicting the cellular behavior and thus more efficient applications of these NPs for clinical purposes. Consequently, a comprehensive review is necessary in this field, to clarify the impacts of CeO2-NPs on various signaling pathways.

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Behavior of nanoceria in biologically-relevant environments

Environmental Science Nano ◽

10.1039/c4en00052h ◽

2014 ◽

Vol 1 (6) ◽

pp. 516-532 ◽

Cited By ~ 49

Author(s):

Amit Kumar ◽

Soumen Das ◽

Prabhakaran Munusamy ◽

William Self ◽

Donald R. Baer ◽

...

Keyword(s):

Cerium Oxide ◽

Cerium Oxide Nanoparticles ◽

Biological Research ◽

Oxide Nanoparticles ◽

Biologically Relevant ◽

Anti Oxidant

Cerium oxide nanoparticles (nanoceria) have gained considerable attention in biological research due to their anti-oxidant like behaviour and regenerative nature.

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Anti-inflammatory Properties of Cerium Oxide Nanoparticles

Small ◽

10.1002/smll.200901048 ◽

2009 ◽

Vol 5 (24) ◽

pp. 2848-2856 ◽

Cited By ~ 408

Author(s):

Suzanne M. Hirst ◽

Ajay S. Karakoti ◽

Ron D. Tyler ◽

Nammalwar Sriranganathan ◽

Sudipta Seal ◽

...

Keyword(s):

Cerium Oxide ◽

Cerium Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Anti Inflammatory

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Different approaches to synthesise cerium oxide nanoparticles and their corresponding physical characteristics, ROS scavenging and anti-inflammatory capabilities

Journal of Materials Chemistry B ◽

10.1039/d1tb01091c ◽

2021 ◽

Author(s):

Yuao Wu ◽

Hang Thu Ta

Keyword(s):

Cerium Oxide ◽

Physical Characteristics ◽

Cerium Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Biological Applications ◽

Ros Scavenging ◽

Trivalent Cerium ◽

Anti Inflammatory ◽

Tetravalent Cerium

The biological applications of cerium oxide nanoparticles (nanoceria) have received extensive attention in recent decades. The coexistence of trivalent cerium and tetravalent cerium on the surface of nanoceria allows the...

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