scholarly journals The Long-Term Treatment of Short Bowel Syndrome

2016 ◽  
Vol 2 ◽  
pp. e6
Author(s):  
Samantha McKenzie Stancu ◽  
◽  
Catalin Gabriel Cirstoveanu ◽  
Keyword(s):  
Short Bowel Syndrome ◽  
Term Treatment ◽  
Short Bowel ◽  
Long Term Treatment

Designing novel teduglutide analogues with improved binding affinity: An in silico peptide engineering approach

2020 ◽  
Vol 16 ◽  
Author(s):  
Ali Akbar Alizadeh ◽  
Siavoush Dastmalchi
Keyword(s):  
Amino Acids ◽  
Short Bowel Syndrome ◽  
Biological Effects ◽  
Term Treatment ◽  
Receptor Interaction ◽  
Alanine Scanning Mutagenesis ◽  
Short Bowel ◽  
Novel Treatments ◽  
Long Term Treatment ◽  
Dynamics Simulations

Introduction: Short bowel syndrome (SBS) is a disabling condition which occurs following the loss of substantial portions of intestine leading to inadequate absorption of nutrients and fluids. Teduglutide is the only drug which has been FDA-approved for long-term treatment of SBS. This medicine exerts its biological effects through binding to the GLP-2 receptor. Methods: The current study aimed to use computational mutagenesis approaches to design novel potent analogues of teduglutide. To this end, the constructed teduglutide-GLP2R 3D model was subjected to the alanine scanning mutagenesis where ARG20, PHE22, ILE23, LEU26, ILE27 and LYS30 were identified as the key amino acids involved in ligand-receptor interaction. In order to design potent teduglutide analogues, using MAESTROweb machine learning method, the residues of teduglutide were virtually mutated into all naturally occurring amino acids and the affinity improving mutations were selected for further analysis using PDBePISA methodology which interactively investigates the interactions established at the interfaces of macromolecules. Result: The calculations resulted in D15I, D15L, D15M and N24M mutations which can improve the binding ability of ligand to receptor. Final evaluation of identified mutations was performed by molecular dynamics simulations indicating that D15I and D15M are the most reliable mutations to increase teduglutide affinity towards its receptor. Conclusion: The findings in the current study may facilitate designing more potent teduglutide analogues leading to the development of novel treatments in short bowel syndrome.

Hypnotherapy is effective in the long-term treatment of functional dyspepsia

2001 ◽  
Vol 120 (5) ◽  
pp. A115-A115 ◽  
Author(s):  
E CALVERT ◽  
L HOUGHTON ◽  
P COOPER ◽  
P WHORWELL
Keyword(s):  
Functional Dyspepsia ◽  
Term Treatment ◽  
Long Term Treatment

1608: Long-Term Treatment with High Doses of Sildenafil Does Not Up-Regulate the Levels of Phosphodiesterase 5 (Pde5) in the Rat Penis

2004 ◽  
Vol 171 (4S) ◽  
pp. 424-424 ◽  
Author(s):  
Monica G. Ferrini ◽  
Eliane G. Valente ◽  
Jacob Rajfer ◽  
Nestor F. Gonzalez-Cadavid
Keyword(s):  
Term Treatment ◽  
Long Term Treatment ◽  
High Doses ◽  
Phosphodiesterase 5

Long-Term Treatment Outcomes for Heroin Dependence: The 11-Year Follow-Up of the ATOS Study

2013 ◽  
Author(s):  
Christina Marel ◽  
Maree Teesson ◽  
Shane Darke ◽  
Katherine Mills ◽  
Joanne Ross ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Term Treatment ◽  
Heroin Dependence ◽  
Long Term Treatment

Relevance of quantitative HBsAg (qHBsAg) during long-term treatment of chronic hepatitis B with nucleos(t)ide analogues (NUCs)

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
J Jaroszewicz ◽  
H Ho ◽  
K Deterding ◽  
A Markova ◽  
K Wursthorn ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Term Treatment ◽  
Long Term Treatment
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