scholarly journals DBscorer: an open source software for automated accurate analysis of rodent behavior in forced swim test and tail suspension test

eNeuro ◽  
2021 ◽  
pp. ENEURO.0305-21.2021
Author(s):  
Arnab Nandi ◽  
Garima Virmani ◽  
Aatmika Barve ◽  
Swananda Marathe
Keyword(s):  
Open Source ◽  
Open Source Software ◽  
Forced Swim Test ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Accurate Analysis ◽  
Swim Test ◽  
Rodent Behavior ◽  
Forced Swim ◽  
Suspension Test

scholarly journals Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

2017 ◽  
Vol 6 (3) ◽  
pp. 695
Author(s):  
Chiranjeevi Bonda ◽  
Sudhir Pawar ◽  
Jaisen Lokhande
Keyword(s):  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Group I ◽  
Immobility Time ◽  
Suspension Test

Background: The aim of the study was to evaluate the antidepressant effect of opioid analgesic tramadol using forced swim test and tail suspension test models.Methods: The antidepressant effect was assessed by recording the immobility time in Forced swim test (FST) and Tail suspension test (TST). The mice were randomly divided into five groups. Mice belonging to group I was given normal saline (0.1ml/kg) which acted as control. Group II received imipramine (15mg/kg) considered as the standard drug tramadol was given in graded dose (10, 20 and 40 mg/kg) to mice of groups III, IV, V respectively. All drugs were administered intraperitoneally for seven successive days; test was done on 7th day.Results: Tramadol and Imipramine showed antidepressant activity when compared to control. There is dose dependent increase in antidepressant activity of tramadol. The antidepressant activity of imipramine was significantly (P<0.05) more than tramadol at dose 10 and 20 mg/kg but antidepressant activity with tramadol 40mg/kg was comparable to imipramine treated mice.Conclusions: The results of this study indicated the presence of antidepressant activity of tramadol at 40mg/kg.

scholarly journals EFFECT OF FLAVONE AND ITS MONOHYDROXY DERIVATIVES ON ANIMAL MODELS OF DEPRESSION IN SWISS ALBINO MICE

2019 ◽  
pp. 513-517
Author(s):  
SHANMUGAPRIYAN S ◽  
JAIKUMAR S ◽  
VISWANATHAN S ◽  
PARIMALA K ◽  
RAJESH M
Keyword(s):  
Animal Models ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Animal Models Of Depression ◽  
Pre Treatment ◽  
Suspension Test

Objectives: This research was designed to investigate the antidepressant activity of a few structurally related flavones (flavone, 3‑hydroxyflavone, and 7‑hydroxyflavone) and the possible mechanisms involved. Methods: Antidepressant activity was evaluated in mice by subjecting them to forced swim test and tail suspension test. The involvement of adrenergic, serotonergic, nitric oxide (NO), and opioid mechanisms was investigated using suitable interacting chemicals. Results: Flavone, 3‑hydroxyflavone, and 7‑hydroxyflavone exhibited a significant and dose‑dependent reduction in total time of immobility in the forced swim test and tail suspension test. Pre‑treatment with alpha‑methyl‑para‑tyrosine and parachlorophenyl alanine attenuated the reduction in immobility period produced by flavone and its derivatives in forced swim test. Naloxone pre‑treatment partially reversed the effect of flavone while L‑arginine pre‑treatment did not alter their effect. Conclusion: The investigated flavones exhibited promising antidepressant activity in both the animal models of depression. However, the flavone compounds did not alter the motor coordination and ambulatory behavior in the Rotarod and locomotor activity test. The participation of serotonergic, adrenergic, and opioid mechanism in the antidepressant activity of these compounds was elucidated from the results, and the role of NO pathway was excluded.

Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice

Life Sciences ◽  
2007 ◽  
Vol 81 (11) ◽  
pp. 933-938 ◽  
Author(s):  
Wen-Huang Peng ◽  
Kuan-Lin Lo ◽  
Yi-Hsuen Lee ◽  
Tai-Huang Hung ◽  
Ying-Chih Lin
Keyword(s):  
Forced Swim Test ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Suspension Test

scholarly journals The protective effect of L. siceraria against depression using behavioural despair animal models

2018 ◽  
Vol 7 (7) ◽  
pp. 1391
Author(s):  
Karunakar Kota ◽  
Sandhya Sharma ◽  
P. Ragavendra ◽  
Jameela Tahashildar
Keyword(s):  
Animal Models ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Repeated Treatment ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Suspension Test

Background: In recent years, the search for novel pharmacotherapy from medicinal plants for psychiatric illness was significantly progressed. The present study was performed to evaluate the antidepressant activity of ethanolic extract of Lagenaria siceraria in animal models.Methods: The antidepressant activity of ethanolic extract of the fruit of L. siceraria in rats was assessed using forced swim test and tail suspension test. Imipramine at 15 mg/kg was used as standard antidepressant drug.Results: The ethanolic extract of L. siceraria fruit (EELS) was significantly and dose-dependently reduced the duration of immobility after repeated treatment for 7 days in Forced swim test and Tail suspension Test. But combination of L. siceraria (200mg/kg) with Imipramine gave a highly significant result (p<0.001) in reduction of immobility duration and the effect of high dose (400mg/kg) with imipramine (15mg/kg) did not decrease the duration of immobility period in both animal models at end of the study. In this work the dose of 400mg/kg afforded more protection than the imipramine.Conclusions: The results obtained from this study was indicate that the antidepressant activity of L. siseraria.

Albiflorin Ameliorates Depressive-like Behaviors in Mice Induced by Chronic Unpredictable Mild Stress

2019 ◽  
Vol 18 (1) ◽  
pp. 102-107
Author(s):  
Wang Jun ◽  
Wan Yanfang ◽  
Zheng Nan
Keyword(s):  
Forced Swim Test ◽  
Tail Suspension Test ◽  
Underlying Mechanism ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Tail Suspension ◽  
Sucrose Consumption ◽  
Swim Test ◽  
Forced Swim ◽  
Suspension Test

Depression is a common psychiatric disorder with a high recurrence rate leading to suicidal thoughts in some cases. Albiflorin is a monoterpene glycoside that is commonly used in the treatment of psychiatric disorders. However, the underlying mechanism of albiflorin on depression is unclear and remains to be investigated. To this end, a mouse model of depression was established via chronic unpredictable mild stress treatment. Next, the effects of albiflorin on depression in these mice were evaluated using the sucrose preference test, forced swim test, tail suspension test, and open field test. The results showed that chronic unpredictable mild stress decreased sucrose consumption, while albiflorin (10 mg/kg) treatment significantly increased sucrose consumption just as fluoxetine (10 mg/kg), a drug commonly used to treat depression. Moreover, both albiflorin and fluoxetine demonstrated significant decrease in immobility time in the forced swim test and tail suspension test with no change in spontaneous locomotor activities. Finally, the underlying mechanism of albiflorin was evaluated using western blot. Results showed an up-regulation of phospho-Akt without changing total-Akt, indicating that albiflorin improved the depression symptoms via inactivation of the Akt signaling pathway. Therefore, albiflorin might be a potential therapeutic treatment for depression.

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