scholarly journals Lyso-lipid induced oligodendrocytes maturation underlie restoration of optic nerve function

eNeuro ◽  
2022 ◽  
pp. ENEURO.0429-21.2022
Author(s):  
Anddre Osmar Valdivia ◽  
Sanjoy K. Bhattacharya
Keyword(s):  
Optic Nerve ◽  
Nerve Function

The Effect of Pulsed Electromagnetic Field on Patients with Endocrine Ophthalmopathy

1998 ◽  
Vol 8 (4) ◽  
pp. 253-257
Author(s):  
J. Jankauskienė ◽  
A. Paunksnis ◽  
A Blužienė ◽  
J. Saulgozis
Keyword(s):  
Electromagnetic Field ◽  
Optic Nerve ◽  
Soft Tissue ◽  
Nerve Function ◽  
Pulsed Electromagnetic Field ◽  
Ocular Movements ◽  
Endocrine Ophthalmopathy ◽  
Field Therapy ◽  
Pulsed Electromagnetic ◽  
Pulsed Electromagnetic Field Therapy

Purpose To evaluate eye signs, proptosis and ocular movements in patients with endocrine ophthalmopathy under the influence of pulsed electromagnetic field therapy. Methods We examined 14 patients (9 women, 5 men) with endocrine ophthalmopathy and evaluated eye signs, proptosis and ocular movements before and after the course of pulsed electromagnetic field therapy, and 12 controls. Their age ranged from 29 to 57 years. Visual sensitivity was investigated with a static automatic perimeter (Allergan Humphrey Field Analyzer). The score was calculated by rating the severity of involvement of soft tissue, proptosis, extraocular movements, corneal state and optic nerve function on a scale from 0 to 3. The pulsed electromagnetic field procedures were carried out with the help of electromagnetic spectacles. Results Pulsed electromagnetic field therapy reduced the score for soft tissue and proptosis in patients who suffered from endocrine ophthalmopathy. There was fall in the mean score for ocular movements, corneal and optic nerve function but it did not reach significance after treatment. Electromagnetic field therapy has no useful effect on visual signs and eye movements in two patients who had had the illness more than two years. Conclusions Localised pulsed electromagnetic field procedures can be recommended, together with other methods of conservative treatment of endocrine ophthalmopathy.

Intraoperative Awakening for Vision Examination during Ophthalmic Artery Aneurysm Clipping: Technical Case Report

2005 ◽  
Vol 56 (suppl_4) ◽  
pp. ONS-E440-ONS-E440 ◽  
Author(s):  
Peng Chen ◽  
Ian F. Dunn ◽  
Linda S. Aglio ◽  
Arthur L. Day ◽  
Kai U. Frerichs ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ophthalmic Artery ◽  
Artery Aneurysm ◽  
The Body ◽  
External Carotid ◽  
Parent Artery ◽  
Nerve Function ◽  
Intraoperative Angiography ◽  
Aneurysm Clipping ◽  
Valuable Adjunct

Abstract OBJECTIVE AND IMPORTANCE: We present a case of a patient with an ophthalmic artery aneurysm in which the ophthalmic artery originated from the body of the aneurysm, requiring sacrifice of the ophthalmic artery to achieve complete aneurysm obliteration. We awakened the patient intraoperatively to assess optic nerve function after clipping and were able to confirm optic nerve function. Controlled intraoperative awakening proved a valuable adjunct to intraoperative angiography in determining the immediate consequences of sacrifice of the ophthalmic artery. CLINICAL PRESENTATION: The patient was a 55-year-old right-handed woman with a 3-month history of episodic blurriness in her left eye; imaging demonstrated an unruptured 5-mm left ophthalmic artery aneurysm in which the ophthalmic artery originated from the body of the aneurysm. INTERVENTION: Complete obliteration of the aneurysm required clip placement across the neck of the aneurysm, incorporating not only the aneurysm but also the ophthalmic artery. Aware that sacrifice of the ophthalmic artery was likely, we awakened the patient after clipping and before dural closure to evaluate her optic nerve function. Once fully awake, the patient was able to execute simple commands and conclusively confirm light perception in both of her eyes. She was then reanesthetized, and intraoperative angiography showed successful aneurysm obliteration and parent artery patency. CONCLUSION: The ophthalmic artery can be sacrificed during aneurysm clipping without loss of vision in many cases, most likely because of adequate collateral filling from the external carotid artery. Certainty about the visual consequences of sacrifice of the ophthalmic artery, however, is difficult to obtain preoperatively or intraoperatively. Intraoperative awakening for evaluation of optic nerve function served as a useful technique to assess the acute results of interruption of ophthalmic artery flow in this case.

“Balanced” Orbital Decompression for Severe Graves' Orbitopathy: Technique with Treatment Algorithm

2003 ◽  
Vol 128 (2) ◽  
pp. 228-235 ◽  
Author(s):  
Kacker Ashutosh ◽  
Kazim Michael ◽  
Murphy Mark ◽  
Trokel Stephen ◽  
G. Close Lanny
Keyword(s):  
Optic Nerve ◽  
Optic Neuropathy ◽  
Treatment Algorithm ◽  
Orbital Decompression ◽  
Nerve Function ◽  
Muscle Involvement ◽  
Compressive Optic Neuropathy ◽  
Average Decrease ◽  
Graves Orbitopathy ◽  
Low Incidence

BACKGROUND: Graves' orbitopathy can produce proptosis, compressive optic neuropathy, and extraocular motility abnormalities; symptoms result from an increase in orbital volume due to expansion of intraorbital fat, with or without extraocular muscle involvement. STUDY DESIGN: We conducted a chart review of patients who underwent orbital decompression to treat Graves' orbitopathy. Twenty-two orbits (13 patients) underwent orbital bone decompression, of which 17 orbits (9 patients) underwent the combined medial and lateral “balanced” decompression. RESULTS: All patients had significant improvement with an average decrease in proptosis of 5.9 mm in the balanced decompression group. Restoration of normal optic nerve function was achieved in all patients with compressive optic neuropathy. Diplopia was noted in 4 patients (30.7%) preoperatively. Two patients had new postoperative diplopia (15.35%). CONCLUSION: In our experience, “balanced” decompression results in a reduction of proptosis and improved optic nerve function and has a low incidence of complications.

Preserving and Restoring Optic Nerve Function

2010 ◽  
Vol 30 (4) ◽  
pp. 303-304
Author(s):  
Lynn K Gordon ◽  
Jeffrey L Bennett
Keyword(s):  
Optic Nerve ◽  
Nerve Function

Impact of Obstructive Sleep Apnea on Optic Nerve Function in Patients With Craniosynostosis and Recurrent Intracranial Hypertension

2019 ◽  
Vol 207 ◽  
pp. 356-362 ◽  
Author(s):  
Josephine Q.N. Nguyen ◽  
Cory M. Resnick ◽  
Yoon-Hee Chang ◽  
Ronald M. Hansen ◽  
Anne B. Fulton ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Optic Nerve ◽  
Intracranial Hypertension ◽  
Nerve Function ◽  
Obstructive Sleep
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