Influence of Pulsed Magnetic Field Therapy on Hand Function Post Flexor Tendon Repair: A Randomized Controlled Trial

IntroductionPurpose: The study was conducted to investigate the influence of pulsed magnetic field therapy on hand function, grip and pinch grip strength in post flexor tendon repair patients.Material and methodsMethods: Fifty male patients with flexor tendon repair took part in this research, with ages ranging from 25 to 50 years. They were assigned randomly into two groups: Group A (experimental) received pulsed magnetic therapy together with exercise, whereas Group B (control) received only exercise. Evaluation of hand grip strength with Jamar hydraulic hand dynamometer, pinch strength with Baseline pinch gauge and hand function with Michigan Hand Outcomes Questionnaire, all measurements were made before and after the treatment. They were received 16 sessions for 8 weeks (2 sessions/week).ResultsResults: 2 x2 mixed design MANOVA revealed that no significant difference between both groups pre- treatment and post treatment in MHOQ total, function, aesthetic (p>0.05) and in hand grip strength while there was a significant difference across groups after treatment in the strength of pinch grip, MHOQ ADL, pain and satisfaction p <0.05), there was also a significant difference between pre- and post-treatment within groups in all outcome measures. (p <0.05).ConclusionsConclusion: PMF increases the efficiency of physical therapy treatment and it also increases the strength of both hand grip and pinches grip in patients after flexor tendon repair in zone II.

Effect of Pulsed Electro-Magnetic Field (PEMF) Therapy and Conventional Physiotherapy on Lipid Profile- A Randomised Control Trial

Introduction: The varying levels of lipids in the blood is defined as lipid profile, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides are most commonly reported. Pulsed Electromagnetic field therapy, is a therapy involves powerful pulsed energy waves passing through injured and damaged area of body of patients. Waves of pulsed electromagnetic field are painless and quick to pass through the damaged cells in the damaged region, increasing the oxygen pressure activating and regenerating cells. Methodology: A Total of 40 subjects will be included in the study. Divided in two groups 20 in group 1 and 20 in group 2.Group 1 will receive Pulsed electromagnetic field therapy (PEMF) with aerobic and resistance exercises while Group 2 will receive aerobic and resistance training exercises as conventional physiotherapy technique. Discussion: 13 meta-analyses were categorized by Pedersen and Saltin, they have reported lipid profile involvement following exercise. They have described that exercise have a positive effect on the pathogenesis, physical fitness of individuals with dyslipidaemia. Effect of exercise profile on lipid have been stated in few studies. This study will focus on studying the impact of pulsed electromagnetic field therapy on lipid profile. Conclusion: Conclusion will be drawn based on the outcome measures of the study and the statistical analysis.

Nebulization of Low-Dose S-Nitrosoglutathione in Diabetic Stroke Enhances Benefits of Reperfusion and Prevents Post-Thrombolysis Hemorrhage

The COVID-19 pandemic has escalated the occurrence of hypoxia including thrombotic stroke worldwide, for which nitric oxide (NO) therapy seems very promising and translatable. Therefore, various modes/routes of NO-delivery are now being tested in different clinical trials for safer, faster, and more effective interventions against ischemic insults. Intravenous (IV) infusion of S-Nitrosoglutathione (GSNO), the major endogenous molecular pool of NO, has been reported to protect against mechanical cerebral ischemia-reperfusion (IR); however, it has been never tested in any kind of “clinically” relevant thromboembolic stroke models with or without comorbidities and in combination with the thrombolytic reperfusion therapy. Moreover, “IV-effects” of higher dose of GSNO following IR-injury have been contradicted to augment stroke injury. Herein, we tested the hypothesis that nebulization of low-dose GSNO will not alter blood pressure (BP) and will mitigate stroke injury in diabetic mice via enhanced cerebral blood flow (CBF) and brain tissue oxygenation (PbtO2). GSNO-nebulization (200 μg/kgbwt) did not alter BP, but augmented the restoration of CBF, improved behavioral outcomes and reduced stroke injury. Moreover, GSNO-nebulization increased early reoxygenation of brain tissue/PbtO2 as measured at 6.5 h post-stroke following thrombolytic reperfusion, and enervated unwanted effects of late thrombolysis in diabetic stroke. We conclude that the GSNO-nebulization is safe and effective for enhancing collateral microvascular perfusion in the early hours following stroke. Hence, nebulized-GSNO therapy has the potential to be developed and translated into an affordable field therapy against ischemic events including strokes, particularly in developing countries with limited healthcare infrastructure.

Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair

Bone fracture is a growing public health burden and there is a clinical need for non-invasive therapies to aid in the fracture healing process. Previous studies have demonstrated the utility of electromagnetic (EM) fields in promoting bone repair; however, its underlying mechanism of action is unclear. Interestingly, there is a growing body of literature describing positive effects of an EM field on mitochondria. In our own work, we have previously demonstrated that differentiation of osteoprogenitors into osteoblasts involves activation of mitochondrial oxidative phosphorylation (OxPhos). Therefore, it was reasonable to propose that EM field therapy exerts bone anabolic effects via stimulation of mitochondrial OxPhos. In this study, we show that application of a low intensity constant EM field source on osteogenic cells in vitro resulted in increased mitochondrial membrane potential and respiratory complex I activity and induced osteogenic differentiation. In the presence of mitochondrial inhibitor antimycin A, the osteoinductive effect was reversed, confirming that this effect was mediated via increased OxPhos activity. Using a mouse tibial bone fracture model in vivo, we show that application of a low intensity constant EM field source enhanced fracture repair via improved biomechanical properties and increased callus bone mineralization. Overall, this study provides supporting evidence that EM field therapy promotes bone fracture repair through mitochondrial OxPhos activation.

Callahan’s thought field therapy in the management of emotions associated with stress

Taking into account that Thought Field therapy (TFT) is a non-invasive technique for managing emotions, and that it is characterized by being safe and fast, it was applied in a group of 14 people from the workforce of the Center of Childhood Integration and Connivance "Del Bosque", Texcoco, Mexico, who voluntarily expressed some feelings associated with stress before an initial interview, in order to evaluate their effectiveness. 36% of the participants reported presenting anxiety; 29% fear; 21% obsession, and 14% rejection. Once the TFT was completed, these emotions, in all the participants, went from a maximum rating of 10 Units of Discomfort Sensation (UDS) to a minimum of 0 UDS, so it could be established that the TFT technique was effective in managing stressful situations that were to be eradicated, with written opinions that expressed satisfaction on the part of the participants, who had no adverse reactions when the technique was applied to them.