scholarly journals Medial Temporal Lobe Coding of Item and Spatial Information during Relational Binding in Working Memory

2014 ◽  
Vol 34 (43) ◽  
pp. 14233-14242 ◽  
Author(s):  
L. A. Libby ◽  
D. E. Hannula ◽  
C. Ranganath
Keyword(s):  
Working Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Spatial Information ◽  
Relational Binding

Material-specific lateralization of working memory in the medial temporal lobe

2009 ◽  
Vol 47 (1) ◽  
pp. 112-122 ◽  
Author(s):  
Dylan D. Wagner ◽  
Viviane Sziklas ◽  
Krista E. Garver ◽  
Marilyn Jones-Gotman
Keyword(s):  
Working Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

Modulation of medial temporal lobe activity in epilepsy patients with hippocampal sclerosis during verbal working memory

2009 ◽  
Vol 15 (4) ◽  
pp. 536-546 ◽  
Author(s):  
PABLO CAMPO ◽  
FERNANDO MAESTÚ ◽  
IRENE GARCÍA-MORALES ◽  
ANTONIO GIL-NAGEL ◽  
BRYAN STRANGE ◽  
...  
Keyword(s):  
Working Memory ◽  
Episodic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Time Course ◽  
Hippocampal Sclerosis ◽  
Stimulus Presentation ◽  
Verbal Working Memory ◽  
Compelling Evidence ◽  
Electrophysiological Studies

AbstractIt has been traditionally assumed that medial temporal lobe (MTL) is not required for working memory (WM). However, animal lesion and electrophysiological studies and human neuropsychological and neuroimaging studies have provided increasing evidences of a critical involvement of MTL in WM. Based on previous findings, the central aim of this study was to investigate the contribution of the MTL to verbal WM encoding. Here, we used magnetoencephalography (MEG) to compare the patterns of MTL activation of 9 epilepsy patients suffering from left hippocampal sclerosis with those of 10 healthy matched controls while they performed a verbal WM task. MEG recordings allow detailed tracking of the time course of MTL activation. We observed impaired WM performance associated with changes in the dynamics of MTL activity in epilepsy patients. Specifically, whereas patients showed decreased activity in damaged MTL, activity in the contralateral MTL was enhanced, an effect that became significant in the 600- to 700-ms interval after stimulus presentation. These findings strongly support the crucial contribution of MTL to verbal WM encoding and provide compelling evidence for the proposal that MTL contributes to both episodic memory and WM. Whether this pattern is signaling reorganization or a normal use of a damaged structure is discussed. (JINS, 2009, 15, 536–546.)

Forward Processing of Object–Location Association from the Ventral Stream to Medial Temporal Lobe in Nonhuman Primates

2019 ◽  
Vol 30 (3) ◽  
pp. 1260-1271 ◽  
Author(s):  
He Chen ◽  
Yuji Naya
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Spatial Information ◽  
Object Location ◽  
Object Identity ◽  
Downstream Target ◽  
Parahippocampal Cortex ◽  
Ventral Pathway ◽  
Additive Form ◽  
Location Association

Abstract While the hippocampus (HPC) is a prime candidate combining object identity and location due to its strong connections to the ventral and dorsal pathways via surrounding medial temporal lobe (MTL) areas, recent physiological studies have reported spatial information in the ventral pathway and its downstream target in MTL. However, it remains unknown whether the object–location association proceeds along the ventral MTL pathway before HPC. To address this question, we recorded neuronal activity from MTL and area anterior inferotemporal cortex (TE) of two macaques gazing at an object to retain its identity and location in each trial. The results showed significant effects of object–location association at a single-unit level in TE, perirhinal cortex (PRC), and HPC, but not in the parahippocampal cortex. Notably, a clear area difference emerged in the association form: 1) representations of object identity were added to those of subjects’ viewing location in TE; 2) PRC signaled both the additive form and the conjunction of the two inputs; and 3) HPC signaled only the conjunction signal. These results suggest that the object and location signals are combined stepwise at TE and PRC each time primates view an object, and PRC may provide HPC with the conjunctional signal, which might be used for encoding episodic memory.

Neuronal activities in medial temporal lobe during retrieval from working memory

2011 ◽  
Vol 71 ◽  
pp. e382
Author(s):  
Masato Inoue ◽  
Masafumi Nejime ◽  
Akichika Mikami
Keyword(s):  
Working Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

scholarly journals Visual Working Memory Capacity and the Medial Temporal Lobe

2012 ◽  
Vol 32 (10) ◽  
pp. 3584-3589 ◽  
Author(s):  
A. Jeneson ◽  
J. T. Wixted ◽  
R. O. Hopkins ◽  
L. R. Squire
Keyword(s):  
Working Memory ◽  
Visual Working Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Working Memory Capacity ◽  
Memory Capacity

scholarly journals The medial temporal lobe supports sensing-based visual working memory

2016 ◽  
Vol 89 ◽  
pp. 485-494 ◽  
Author(s):  
Robin I. Goodrich ◽  
Andrew P. Yonelinas
Keyword(s):  
Working Memory ◽  
Visual Working Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

scholarly journals Representations of local spatial information in the human medial temporal lobe during memory-guided navigation

2020 ◽  
Author(s):  
Shao-Fang Wang ◽  
Valerie A. Carr ◽  
Serra E. Favila ◽  
Jeremy N. Bailenson ◽  
Thackery I. Brown ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Spatial Information ◽  
Activity Patterns ◽  
Critical Role ◽  
Neural Representations ◽  
Parahippocampal Cortex ◽  
Pattern Similarity ◽  
Cortical Regions ◽  
Goal Directed Behavior

AbstractThe hippocampus (HC) and surrounding medial temporal lobe (MTL) cortical regions play a critical role in spatial navigation and episodic memory. However, it remains unclear how the interaction between the HC’s conjunctive coding and mnemonic differentiation contributes to neural representations of spatial environments. Multivariate functional magnetic resonance imaging (fMRI) analyses enable examination of how human HC and MTL cortical regions encode multidimensional spatial information to support memory-guided navigation. We combined high-resolution fMRI with a virtual navigation paradigm in which participants relied on memory of the environment to navigate to goal locations in two different virtual rooms. Within each room, participants were cued to navigate to four learned locations, each associated with one of two reward values. Pattern similarity analysis revealed that when participants successfully arrived at goal locations, activity patterns in HC and parahippocampal cortex (PHC) represented room-goal location conjunctions and activity patterns in HC subfields represented room-reward-location conjunctions. These results add to an emerging literature revealing hippocampal conjunctive representations during goal-directed behavior.

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