scholarly journals Medial Temporal Lobe Damage Causes Deficits in Episodic Memory and Episodic Future Thinking Not Attributable to Deficits in Narrative Construction

2011 ◽  
Vol 31 (28) ◽  
pp. 10262-10269 ◽  
Author(s):  
E. Race ◽  
M. M. Keane ◽  
M. Verfaellie
Keyword(s):  
Episodic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Narrative Construction ◽  
Episodic Future Thinking ◽  
Future Thinking

scholarly journals Medial Temporal Lobe Contributions to Episodic Future Thinking: Scene Construction or Future Projection?

2016 ◽  
Vol 28 (2) ◽  
pp. 447-458 ◽  
Author(s):  
D J Palombo ◽  
S M Hayes ◽  
K M Peterson ◽  
M M Keane ◽  
M Verfaellie
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Episodic Future Thinking ◽  
Future Thinking ◽  
Future Projection ◽  
Scene Construction

Children show adult-like hippocampal pattern separation for familiar but not novel events

2020 ◽  
Author(s):  
Susan L. Benear ◽  
Elizabeth A. Horwath ◽  
Emily Cowan ◽  
M. Catalina Camacho ◽  
Chi Ngo ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Developmental Change ◽  
Pattern Separation ◽  
Developmental Changes ◽  
Similarity Analysis ◽  
Separation Processes ◽  
Parahippocampal Cortex ◽  
Pattern Similarity

The medial temporal lobe (MTL) undergoes critical developmental change throughout childhood, which aligns with developmental changes in episodic memory. We used representational similarity analysis to compare neural pattern similarity for children and adults in hippocampus and parahippocampal cortex during naturalistic viewing of clips from the same movie or different movies. Some movies were more familiar to participants than others. Neural pattern similarity was generally lower for clips from the same movie, indicating that related content taxes pattern separation-like processes. However, children showed this effect only for movies with which they were familiar, whereas adults showed the effect consistently. These data suggest that children need more exposures to stimuli in order to show mature pattern separation processes.

Modulation of medial temporal lobe activity in epilepsy patients with hippocampal sclerosis during verbal working memory

2009 ◽  
Vol 15 (4) ◽  
pp. 536-546 ◽  
Author(s):  
PABLO CAMPO ◽  
FERNANDO MAESTÚ ◽  
IRENE GARCÍA-MORALES ◽  
ANTONIO GIL-NAGEL ◽  
BRYAN STRANGE ◽  
...  
Keyword(s):  
Working Memory ◽  
Episodic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Time Course ◽  
Hippocampal Sclerosis ◽  
Stimulus Presentation ◽  
Verbal Working Memory ◽  
Compelling Evidence ◽  
Electrophysiological Studies

AbstractIt has been traditionally assumed that medial temporal lobe (MTL) is not required for working memory (WM). However, animal lesion and electrophysiological studies and human neuropsychological and neuroimaging studies have provided increasing evidences of a critical involvement of MTL in WM. Based on previous findings, the central aim of this study was to investigate the contribution of the MTL to verbal WM encoding. Here, we used magnetoencephalography (MEG) to compare the patterns of MTL activation of 9 epilepsy patients suffering from left hippocampal sclerosis with those of 10 healthy matched controls while they performed a verbal WM task. MEG recordings allow detailed tracking of the time course of MTL activation. We observed impaired WM performance associated with changes in the dynamics of MTL activity in epilepsy patients. Specifically, whereas patients showed decreased activity in damaged MTL, activity in the contralateral MTL was enhanced, an effect that became significant in the 600- to 700-ms interval after stimulus presentation. These findings strongly support the crucial contribution of MTL to verbal WM encoding and provide compelling evidence for the proposal that MTL contributes to both episodic memory and WM. Whether this pattern is signaling reorganization or a normal use of a damaged structure is discussed. (JINS, 2009, 15, 536–546.)

scholarly journals Dynamic Theta Networks in the Human Medial Temporal Lobe Support Episodic Memory

2019 ◽  
Vol 29 (7) ◽  
pp. 1100-1111.e4 ◽  
Author(s):  
Ethan A. Solomon ◽  
Joel M. Stein ◽  
Sandhitsu Das ◽  
Richard Gorniak ◽  
Michael R. Sperling ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe

Episodic memory: It's about time (and space)

1999 ◽  
Vol 22 (3) ◽  
pp. 463-464
Author(s):  
Lynn Nadel ◽  
Lee Ryan ◽  
Katrina Keil ◽  
Karen Putnam
Keyword(s):  
Episodic Memory ◽  
Retrograde Amnesia ◽  
Temporal Lobe ◽  
Memory Consolidation ◽  
Medial Temporal Lobe ◽  
Anterograde Amnesia ◽  
Time And Space ◽  
Neuronal Ensembles ◽  
Alternative Approach

Aggleton & Brown rightly point out the shortcomings of the medial temporal lobe hypothesis as an approach to anterograde amnesia. Their broader perspective is a necessary corrective, and one hopes it will be taken very seriously. Although they correctly note the dangers of conflating recognition and recall, they themselves make a similar mistake in discussing familiarity; we suggest an alternative approach. We also discuss implications of their view for an analysis of retrograde amnesia. The notion that there are two routes by which the hippocampus can reactivate neuronal ensembles in the neocortex could help us understand some currently puzzling facts about the dynamics of memory consolidation.

scholarly journals Characterization of brain network supporting episodic memory in the absence of one medial temporal lobe

2019 ◽  
Vol 40 (7) ◽  
pp. 2188-2199 ◽  
Author(s):  
Woorim Jeong ◽  
Hyeongrae Lee ◽  
June Sic Kim ◽  
Chun Kee Chung
Keyword(s):  
Episodic Memory ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Brain Network

Episodic Future Thinking and Cognitive Aging

2018 ◽  
Author(s):  
Daniel L. Schacter ◽  
Aleea L. Devitt ◽  
Donna Rose Addis
Keyword(s):  
Older Adults ◽  
Problem Solving ◽  
Episodic Memory ◽  
Prospective Memory ◽  
Cognitive Aging ◽  
Episodic Future Thinking ◽  
Future Thinking ◽  
Age Related ◽  
Prosocial Intentions ◽  
Age Related Changes

Episodic future thinking refers to the ability to imagine or simulate experiences that might occur in an individual’s personal future. It has been known for decades that cognitive aging is associated with declines in episodic memory, and recent research has documented correlated age-related declines in episodic future thinking. Previous research has considered both cognitive and neural mechanisms that are responsible for age-related changes in episodic future thinking, as well as effects of aging on the functions served by episodic future thinking. Studies concerned with mechanism indicate that multiple cognitive mechanisms contribute to changes in episodic future thinking during aging, including episodic memory retrieval, narrative style, and executive processes. Recent studies using an episodic specificity induction—brief training in recollecting episodic details of a recent experience—have proven useful in separating the contributions of episodic retrieval from other non-episodic processes during future thinking tasks in both old and young adults. Neuroimaging studies provide preliminary evidence of a role for age-related changes in default and executive brain networks in episodic future thinking and autobiographical planning. Studies concerned with function have examined age-related effects on the link between episodic future thinking and a variety of processes, including everyday problem-solving, prospective memory, prosocial intentions, and intertemporal choice/delay discounting. The general finding in these studies is for age-related reductions, consistent with the work on mechanisms that consistently reveals reduced episodic detail in older adults when they imagine future events. However, several studies have revealed that episodic simulation nonetheless confers some benefits for tasks tapping adaptive functions in older adults, such as problem-solving, prospective memory, and prosocial intentions, even though age-related deficits on these tasks are not eliminated or reduced by episodic future thinking.

Sign in / Sign up

Export Citation Format

Share Document