scholarly journals NMDA Receptor and Nitric Oxide Synthase Activation Regulate Polysialylated Neural Cell Adhesion Molecule Expression in Adult Brainstem Synapses

2001 ◽  
Vol 21 (13) ◽  
pp. 4721-4730 ◽  
Author(s):  
Farima Bouzioukh ◽  
Fabien Tell ◽  
André Jean ◽  
Geneviève Rougon
Keyword(s):  
Nitric Oxide ◽  
Cell Adhesion ◽  
Nmda Receptor ◽  
Nitric Oxide Synthase ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Adhesion Molecule Expression ◽  
Neural Cell Adhesion ◽  
Oxide Synthase

scholarly journals Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration.

1996 ◽  
Vol 135 (6) ◽  
pp. 1565-1581 ◽  
Author(s):  
C Wang ◽  
W F Pralong ◽  
M F Schulz ◽  
G Rougon ◽  
J M Aubry ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Adhesion ◽  
Nmda Receptor ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Polysialic Acid ◽  
Neural Cell ◽  
Adhesion Molecule Expression ◽  
Neural Cell Adhesion

The capacity for long-distance migration of the oligodendrocyte precursor cell, oligodendrocyte-type 2 astrocyte (O-2A), is essential for myelin formation. To study the molecular mechanisms that control this process, we used an in vitro migration assay that uses neurohypophysial explants. We provide evidence that O-2A cells in these preparations express functional N-methyl-D-aspartate (NMDA) receptors, most likely as homomeric complexes of the NR1 subunit. We show that NMDA evokes an increase in cytosolic Ca2+ that can be blocked by the NMDA receptor antagonist AP-5 and by Mg2+. Blocking the activity of these receptors dramatically diminished O-2A cell migration from explants. We also show that NMDA receptor activity is necessary for the expression by O-2A cells of the highly sialylated polysialic acid-neural cell adhesion molecule (PSA-NCAM) that is required for their migration. Thus, glutamate or glutamate receptor ligands may regulate O-2A cell migration by modulating expression of PSA-NCAM. These studies demonstrate how interactions between ionotropic receptors, intracellular signaling, and cell adhesion molecule expression influence cell surface properties, which in turn are critical determinants of cell migration.

Neural cell adhesion molecule expression in thyroid cancer

1996 ◽  
Author(s):  
Y Miyajima ◽  
S Ota ◽  
H Yasukawa ◽  
M Zenmyou ◽  
M Morimatsu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Adhesion Molecule Expression ◽  
Neural Cell Adhesion
Sign in / Sign up

Export Citation Format

Share Document