scholarly journals Elevated Postsynaptic [Ca2+]iand L-Type Calcium Channel Activity in Aged Hippocampal Neurons: Relationship to Impaired Synaptic Plasticity

2001 ◽  
Vol 21 (24) ◽  
pp. 9744-9756 ◽  
Author(s):  
Olivier Thibault ◽  
Robert Hadley ◽  
Philip W. Landfield
Keyword(s):  
Synaptic Plasticity ◽  
Calcium Channel ◽  
Hippocampal Neurons ◽  
Channel Activity

ABNORMAL CALCIUM CHANNEL ACTIVITY OF THE HIPPOCAMPAL NEURONS IN SPONTANEOUSLY EPILEPTIC RAT (SER), A DOUBLE MUTANT.

1992 ◽  
Vol 15 ◽  
pp. 164B
Author(s):  
M. Sasa ◽  
K. Ishihara ◽  
T. Momlyama ◽  
H. Ujihara ◽  
T. Serikawa ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Hippocampal Neurons ◽  
Double Mutant ◽  
Channel Activity

scholarly journals MicroRNA132 Modulates Short-Term Synaptic Plasticity but Not Basal Release Probability in Hippocampal Neurons

PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15182 ◽  
Author(s):  
Talley J. Lambert ◽  
Daniel R. Storm ◽  
Jane M. Sullivan
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Neurons ◽  
Short Term ◽  
Release Probability ◽  
Basal Release

scholarly journals Glucose-6-Phosphate Dehydrogenase and NADPH Redox Regulates Cardiac Myocyte L-Type Calcium Channel Activity and Myocardial Contractile Function

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e45365 ◽  
Author(s):  
Dhwajbahadur K. Rawat ◽  
Peter Hecker ◽  
Makino Watanabe ◽  
Sukrutha Chettimada ◽  
Richard J. Levy ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Cardiac Myocyte ◽  
Contractile Function ◽  
Channel Activity ◽  
Myocardial Contractile ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Regulation of GABAergic synapse formation and plasticity by GSK3β-dependent phosphorylation of gephyrin

2010 ◽  
Vol 108 (1) ◽  
pp. 379-384 ◽  
Author(s):  
Shiva K. Tyagarajan ◽  
Himanish Ghosh ◽  
Gonzalo E. Yévenes ◽  
Irina Nikonenko ◽  
Claire Ebeling ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Neurons ◽  
Glycogen Synthase ◽  
Phosphorylation Site ◽  
Scaffolding Protein ◽  
Scaffolding Proteins ◽  
Gabaergic Synapse ◽  
Gabaergic Synapses

Postsynaptic scaffolding proteins ensure efficient neurotransmission by anchoring receptors and signaling molecules in synapse-specific subcellular domains. In turn, posttranslational modifications of scaffolding proteins contribute to synaptic plasticity by remodeling the postsynaptic apparatus. Though these mechanisms are operant in glutamatergic synapses, little is known about regulation of GABAergic synapses, which mediate inhibitory transmission in the CNS. Here, we focused on gephyrin, the main scaffolding protein of GABAergic synapses. We identify a unique phosphorylation site in gephyrin, Ser270, targeted by glycogen synthase kinase 3β (GSK3β) to modulate GABAergic transmission. Abolishing Ser270 phosphorylation increased the density of gephyrin clusters and the frequency of miniature GABAergic postsynaptic currents in cultured hippocampal neurons. Enhanced, phosphorylation-dependent gephyrin clustering was also induced in vitro and in vivo with lithium chloride. Lithium is a GSK3β inhibitor used therapeutically as mood-stabilizing drug, which underscores the relevance of this posttranslational modification for synaptic plasticity. Conversely, we show that gephyrin availability for postsynaptic clustering is limited by Ca2+-dependent gephyrin cleavage by the cysteine protease calpain-1. Together, these findings identify gephyrin as synaptogenic molecule regulating GABAergic synaptic plasticity, likely contributing to the therapeutic action of lithium.

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