scholarly journals Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator-Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of β-Secretase

2003 ◽  
Vol 23 (30) ◽  
pp. 9796-9804 ◽  
Author(s):  
Magdalena Sastre ◽  
Ilse Dewachter ◽  
Gary E. Landreth ◽  
Timothy M. Willson ◽  
Thomas Klockgether ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein

2008 ◽  
Vol 6 (1-2) ◽  
pp. 1-8 ◽  
Author(s):  
Stefanie Leuchtenberger ◽  
Juan Maler ◽  
Eva Czirr ◽  
Julia Ness ◽  
Stefan F. Lichtenthaler ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Ectodomain Shedding ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

P4-087: Amyloid precursor protein processing: Role of peroxisome proliferator-activated receptor-gamma

2006 ◽  
Vol 2 ◽  
pp. S539-S539
Author(s):  
Roberta Ricciarelli ◽  
Sara Massone ◽  
Cristina d'Abramo ◽  
Umberto M. Marinari ◽  
Maria A. Pronzato
Keyword(s):  
Amyloid Precursor Protein ◽  
Protein Processing ◽  
Precursor Protein ◽  
Amyloid Precursor Protein Processing ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

scholarly journals Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2076 ◽  
Author(s):  
Carmen Ciavarella ◽  
Ilenia Motta ◽  
Sabrina Valente ◽  
Gianandrea Pasquinelli
Keyword(s):  
Peroxisome Proliferator ◽  
Cytokine Storm ◽  
Disease Treatment ◽  
Peroxisome Proliferator Activated Receptor ◽  
Dual Approach ◽  
Ppar Γ ◽  
Inflammatory Drugs ◽  
Coronavirus Infection ◽  
Anti Inflammatory ◽  
Dietary Strategies

The cytokine storm is an abnormal production of inflammatory cytokines, due to the over-activation of the innate immune response. This mechanism has been recognized as a critical mediator of influenza-induced lung disease, and it could be pivotal for COVID-19 infections. Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. In this regard, the peroxisome proliferator-activated receptor (PPAR)-γ, a member of the PPAR transcription factor family, could represent a potential target. Beside the well-known regulatory role on lipid and glucose metabolism, PPAR-γ also represses the inflammatory process. Similarly, the PPAR-γ agonist thiazolidinediones (TZDs), like pioglitazone, are anti-inflammatory drugs with ameliorating effects on severe viral pneumonia. In addition to the pharmacological agonists, also nutritional ligands of PPAR-γ, like curcuma, lemongrass, and pomegranate, possess anti-inflammatory properties through PPAR-γ activation. Here, we review the main synthetic and nutritional PPAR-γ ligands, proposing a dual approach based on the strengthening of the immune system using pharmacological and dietary strategies as an attempt to prevent/treat cytokine storm in the case of coronavirus infection.

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