An Epac-Dependent Pain Pathway

The spinal dorsal horn and its equivalent structure in the brainstem constitute the first sites of synaptic integration in the pain pathway. A huge body of literature exists on alterations in spinal nociceptive signal processing that contribute to the generation of exaggerated pain states and hence to what is generally known as “central sensitization.” Such mechanisms include changes in synaptic efficacy or neuronal excitability, which can be evoked by intense nociceptive stimulation or by inflammatory or neuropathic insults. Some of these changes cause alterations in the functional organization of dorsal horn sensory circuits, leading to abnormal pathological pain sensations. This article reviews the present state of this knowledge. It does not cover the contributions of astrocytes and microglia in detail as their functions are the subject of a separate chapter.

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Chronic Testicular and Groin Pain: Pathway to Relief

Current Urology Reports ◽

10.1007/s11934-017-0722-7 ◽

2017 ◽

Vol 18 (10) ◽

Cited By ~ 8

Author(s):

Nahomy Calixte ◽

Jamin Brahmbhatt ◽

Sijo Parekattil

Keyword(s):

Groin Pain ◽

Pain Pathway

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The effect of occipital nerve field stimulation on the descending pain pathway in patients with fibromyalgia: a water PET and EEG imaging study

BMC Neurology ◽

10.1186/s12883-018-1190-5 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 5

Author(s):

Shaheen Ahmed ◽

Mark Plazier ◽

Jan Ost ◽

Gaetane Stassijns ◽

Steven Deleye ◽

...

Keyword(s):

Imaging Study ◽

Field Stimulation ◽

Occipital Nerve ◽

Pain Pathway

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Efficient and Flexible Synthesis of New Photoactivatable Propofol Analogs

10.26434/chemrxiv.13335428.v1 ◽

2020 ◽

Author(s):

Kenneth Skinner ◽

Joseph Wzorek ◽

Daniel Kahne ◽

Rachelle Gaudet

Keyword(s):

Binding Sites ◽

Transient Receptor Potential ◽

Receptor Potential ◽

General Anesthetic ◽

Bioorthogonal Chemistry ◽

Functional Assays ◽

Pain Pathway ◽

Synthetic Routes ◽

Transient Receptor ◽

Proof Of Principle

Propofol is a widely used general anesthetic, which acts by binding to and modulating several neuronal ion channels. We describe the synthesis of photoactivatable propofol analogs functionalized with an alkyne handle for bioorthogonal chemistry. Such tools are useful for detecting and isolating photolabeled proteins. We designed expedient and flexible synthetic routes to three new diazirine-based crosslinkable propofol derivatives, two of which have alkyne handles. As a proof of principle, we show that these compounds activate heterologously expressed Transient Receptor Potential Ankyrin 1 (TRPA1), a key ion channel of the pain pathway, with a similar potency as propofol in fluorescence-based functional assays. This work demonstrates that installation of the crosslinkable and clickable group on a short nonpolar spacer at the para position of propofol does not affect TRPA1 activation, supporting the utility of these chemical tools in identifying and characterizing potentially druggable binding sites in propofolinteracting proteins.

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Editorial: Regulatory Action of Calcium Channels in Pain Pathway

Frontiers in Cellular Neuroscience ◽

10.3389/fncel.2021.701105 ◽

2021 ◽

Vol 15 ◽

Author(s):

Senthilkumar Rajagopal ◽

Sengottuvelan Murugan ◽

Divya P. Kumar ◽

Girish S. Kesturu ◽

Albert Baskar Arul

Keyword(s):

Calcium Channels ◽

Regulatory Action ◽

Pain Pathway

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The north east back pain pathway: preliminary evaluation findings

The Spine Journal ◽

10.1016/j.spinee.2016.12.022 ◽

2017 ◽

Vol 17 (3) ◽

pp. S7

Author(s):

Cormac Ryan ◽

Charles Greenough ◽

Andrew Coxon ◽

Glynis Peat ◽

Helena Roper ◽

...

Keyword(s):

Back Pain ◽

Preliminary Evaluation ◽

North East ◽

The North ◽

Pain Pathway

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The value of a consultant physiotherapist within a primary care musculoskeletal interface service: part of the spinal multidisciplinary team

International Journal of Therapy and Rehabilitation ◽

10.12968/ijtr.2019.0057 ◽

2021 ◽

Vol 28 (1) ◽

pp. 1-10

Author(s):

Michelle L Angus ◽

Victoria Dickens ◽

Naveed Yasin ◽

James Greenwood ◽

Irfan Siddique

Keyword(s):

Primary Care ◽

Clinical Decision Making ◽

Clinical Decision ◽

Tertiary Referral Centre ◽

Allied Health Professionals ◽

Convenience Sample ◽

Surgical Services ◽

Pain Pathway ◽

The Uk ◽

Case Based

Background/aims The national low back pain pathway in the UK suggests practitioners managing patients with spinal pathology should be specifically trained to do so and have the ability to link with tertiary spinal services when required. The aim of this study was to ensure referrals through to a tertiary spinal surgical centre are appropriate and patients get the correct advice early in their management pathway. Methods A retrospective review of 700 cases were discussed at a spinal case-based discussion meeting in a primary care interface service, compared to services without this model. A convenience sample of cases were analysed with the consultant physiotherapist and those referred from other allied health professionals into the tertiary spinal surgical centre. Case-based team discussion took place before every referral into the tertiary spinal service, with spinal surgical discussion where required. Results Patients referred from other interface services were more likely to require further work-up such as investigations, or be discharged from clinic on their first attendance than those who had been through the case-based discussion. Conclusions A consultant physiotherapist working as part of the spinal team of a tertiary referral centre can help advanced practitioners with their clinical decision making to help prevent unnecessary referrals to spinal surgical services.

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