scholarly journals Diabetes medications with cardiovascular protection in the wake of EMPA-REG OUTCOME: the optimal combination may be metformin, pioglitazone and empagliflozin

2015 ◽  
Vol 15 (4) ◽  
pp. 151 ◽  
Author(s):  
Robert EJ Ryder ◽  
Ralph A Defronzo
Keyword(s):  
Optimal Combination ◽  
Cardiovascular Protection

Maksimalisasi Keuntungan Dengan Pendekatan Metode Simpleks Kasus Pada Pabrik Sosis SM

Liquidity ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Yanti Budiasih
Keyword(s):  
Linear Programming ◽  
Simplex Method ◽  
Optimal Combination ◽  
Optimal Input ◽  
Maximum Profit ◽  
Input Combination

The purpose of this study are to (1) determine the combination of inputs used in producing products such as beef sausages and veal sausage meatball; and (2) determine the optimal combination whether the product can provide the maximum profit. In order to determine the combination of inputs and maximum benefits can be used linear programming with graphical and simplex method. The valuation result shows that the optimal input combination would give a profit of Rp. 1.115 million per day.

An Anthrone-Based Kv7.2/7.3 Channel Blocker with Improved Properties for the Investigation of Psychiatric and Neurodegenerative Disorders

2019 ◽  
Author(s):  
Jacob Porter ◽  
Oscar Vivas-Rodriguez ◽  
C. David Weaver ◽  
Eamonn Dickson ◽  
Abdulmohsen Alsafran ◽  
...  
Keyword(s):  
Patch Clamp ◽  
Neurodegenerative Disorders ◽  
Channel Blocker ◽  
Optimal Combination ◽  
Channel Blockers ◽  
Enolate Alkylation ◽  
Cyp Inhibition ◽  
Alkylation Reactions ◽  
Metabolic Instability

A set of novel Kv7.2/7.3 (KCNQ2/3) channel blockers was synthesized to address several liabilities of the known compounds XE991 (metabolic instability and CYP inhibition) and the clinical compound DMP 543 (acid instability, insolubility, and lipophilicity). Using the anthrone scaffold of the prior channel blockers, alternative heteroarylmethyl substituents were installed via enolate alkylation reactions. Incorporation of a pyridazine and a fluorinated pyridine gave an analog (JDP-107) with an optimal combination of potency (IC<sub>50</sub>= 0.16 𝜇M in a Kv7.2 thallium flux assay), efficacy in a Kv7.2/7.3 patch clamp assay, and drug-like properties.

SWISSMETAL SM184N (BOILLAT 62A)

Alloy Digest ◽  
2001 ◽  
Vol 50 (1) ◽  
Keyword(s):  
Corrosion Resistance ◽  
Physical Properties ◽  
Tensile Properties ◽  
Heat Treating ◽  
Optimal Combination ◽  
Brass Alloy

Abstract Swissmetal SM184N is a free-machining brass alloy with an optimal combination of machinability and cold deformability. This datasheet provides information on composition, physical properties, hardness, elasticity, and tensile properties. It also includes information on corrosion resistance as well as forming, heat treating, and joining. Filing Code: CU-657. Producer or source: Swissmetal Metalworks Ltd, Plant Boillat.

On the Optimal Combination of Annuities and Tontines

2019 ◽  
Author(s):  
An Chen ◽  
Manuel Rach ◽  
Thorsten Sehner
Keyword(s):  
Optimal Combination

Cardiovascular Protection by Dietary Polyphenols

2021 ◽  
pp. 625-635
Author(s):  
Sara Castro-Barquero ◽  
Mana Shahbaz ◽  
Ramon Estruch ◽  
Rosa Casas
Keyword(s):  
Cardiovascular Protection ◽  
Dietary Polyphenols
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