STUDIES ON THE MECHANISM OF DECIDUALIZATION. V.

1963 ◽  
Vol 43 (3) ◽  
pp. 462-468 ◽  
Author(s):  
M. C. Shelesnyak ◽  
Liliane Tic
Keyword(s):  
Nucleic Acids ◽  
Metabolic Activity ◽  
Vaginal Smear ◽  
Uterine Weight ◽  
Close Relationship

ABSTRACT The uteri of pseudopregnant rats show a peak of metabolic activity on the 4th and 5th day of leucocytic smear. After the administration of 20 mg of pyrathiazine Cl on the 4th day of pseudopregnancy (L4) in order to induce decidualization of the progestational endometrium, the metabolic activity of the uterus becomes intensified. The amount of synthesis, estimated by determinations of uterine weight, and amount of protein and nucleic acids, was considered as being related to an oestrogen surge occurring on the 3rd day. The present work was undertaken to confirm the relation between the oestrogen surge and the metabolic activity found in the uterus thereafter by using an antioestrogenic substance: ethanoxytriphetol (MER-25). The experiments were performed in pseudopregnant as well as in decidualizing animals. MER-25 was injected on the 3rd day of leucocytic vaginal smear of pseudopregnancy. Analyses of the uterine components 24, 48, 72, 96 h after the injection of the antioestrogen showed a definite inhibition of the synthetic processes in the uterus of the otherwise untreated pseudopregnant rat as well as in decidualizing uterus. The results, confirm the role of oestrogen surge in the processes of decidualization and the close relationship between the oestrogen surge, increase of metabolism and decidualization.

Lineages

2018 ◽  
Author(s):  
Ruth Gamble
Keyword(s):  
Thirteenth Century ◽  
Buddhist Tradition ◽  
Close Relationship

Chapter 2 examines lineages in Tibetan society and the Buddhist tradition and explains how they influenced the development of Tibet’s reincarnation lineages. It begins by explaining the role of family lineages in thirteenth-century Tibet, describing how lineages helped form identities, created links between people, and served as a mechanism for inheritance. It then examines the three main forms of Buddhist lineages—monastic, Mahāyāna, and Tantric—and shows how these lineages were often intermingled with Tibetan family lineages and inheritance practices. The chapter ends by outlining how lineages associated with manifestation, particularly lineages associated with Avalokiteśvara, underpinned claims by Tibetans to be the manifestation of this bodhisattva and other celestial beings. This chapter also explains how the Karmapas’ reincarnation lineage, traditions, and institutions were presented not as a break from other lineages but as an extension of them, and it highlights the close relationship between lineages and specific places.

Processing the Future

2018 ◽  
Author(s):  
Martin Giraudeau
Keyword(s):  
Venture Capital ◽  
Diagnostic Techniques ◽  
Business Administration ◽  
Knowledge Practices ◽  
Project Appraisal ◽  
Development Corporation ◽  
Close Relationship ◽  
Administrative Procedures ◽  
American Research

This chapter is an analysis of the project appraisal procedures in place at American Research and Development Corporation (ARD) between 1946 and 1973, under the management of Georges F. Doriot. It shows the importance of knowledge technologies and administrative procedures in the way the venture capital company dealt with uncertain futures. The origins of these knowledge practices are traced back to Georges F. Doriot’s own views on business and more generally to the pragmatist movement in business administration of which he was a member. The conduct of project appraisal at ARD is then observed directly, and this reveals its reliance on a rich set of knowledge and diagnostic techniques as well as administrative procedures. These observations allow for a specification of the nature and role of imagination in the entrepreneurship and venture capital practices examined here—in particular, its close relationship with organized knowledge.

scholarly journals OP0045 NLRP12 INVOLVES IN THE LUPUS WITH POSITIVE INTERFERON SIGNATURE

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 23.2-24
Author(s):  
Y. P. Tsao ◽  
F. Y. Tseng ◽  
C. W. Chao ◽  
M. H. Chen ◽  
S. T. Chen
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Animal Models ◽  
Nucleic Acids ◽  
Disease Activity ◽  
Interferon Signature ◽  
Healthy Donors ◽  
Healthy Control ◽  
Lupus Disease Activity

Background:Systemic lupus erythematous (SLE) is a systemic autoimmune disease with diverse etiological factors. It was recognized that interferon (IFN) signature involved in the progress of SLE. NLRP12 (NOD-like receptor family (NLR) pyrin domain containing 12) is a pyrin containing NLR protein that we had linked its new biological function to the cross-regulation of Toll like receptor (TLRs) and Rig-I like receptor (RIG-I) pathways. NLPR12 acts as an innate immune check-point in regulating type I IFNs expression during TLRs and RIG-I activation. The importance of NLRP12 in lupus disease activity remained to be elucidated.Objectives:To clarify the role of NLRP12 in regulating the interferon signature.Methods:Peripheral blood mononuclear cells (PBMCs) were collected from SLE patients and healthy donors for analysis of NLRP12 and IFN-α gene expression by RT-QPCR. PBMCs were applied for Chromatin immuneprecipitation (ChIP) assay and electrical mobility shift assay (EMSA) to determine the putative transcription factor that regulates NLRP12 expression. An involvement of epigenetic regulation of NLRP12 expression in SLE patients was also analyzed. Bone marrow derived dendritic cells (BMDCs) were collected from wild type mouse and Nlrp12 knocked-out mice. Another CD14+ monocytes were isolated from 10 cases of lupus patients and 8 cases of healthy control, following by stimulating different type of nucleic acids, and IFN-α and IL-6 were measured with ELISA assay. CD14+ monocytes in lupus patients were also pre-treated with IFNAR2 antibody for further nucleic acid stimulation. Two mice models were applied for evaluation the role of Nlrp12: intraperitoneal injection of TMPD (2,6,10,14-tetramethylpentadecane, or pristane) in C57BL/6 mice and Faslpr mice. Both models were conducted with and without Nlrp12 knockout.Results:NLRP12 expression was significantly lower in PBMC isolated from SLE patients compared to healthy donors. The inverse correlation was observed in NLRP12 and IFNA gene expression as well as NLRP12 expression and amount of double-stranded DNA autoantibody in SLE patients. NLRP12 expression showed negative correlations with IFN-α treatment, as well as herpes simplex virus-1 (HSV-1) infection. Results from ChIP and EMSA analysis indicated a potential transcription factor 1 (TF-1) regulating NLRP12 promoter activity. TF-1 lead to transcriptional suppression of NLRP12 in SLE PBMC, and it was gradually induced after IFN treatment. Recruitment of TF-1 to NLRP12 promoter in SLE PBMC compared to the healthy PBMC was detected, and increased when treating with IFN. Human CD14+ monocytes collected from lupus and healthy control stimulating with different type of nucleic acids revealing significant increasing level of IFN-α and IL-6 in lupus patients. Among animal models, both pristine induced mice and Faslpr mice revealed increasing autoantibodies production and severity of glomerulonephritis in Nlrp12-/- group in comparison with Nlrp12+/+ ones, indicating the role of NLRP12 in maintaining positive interferon signature as well as disease activity.Conclusion:Expression level of NLRP1.2 has been demonstrated to be a biomarker of disease activity in SLE patients. The NLRP12 was involved in the interferon signature, which was also negatively regulated by TF-1. Both clinical samples and animal models revealed NLRP12 in maintaining the positive interferon signature, indicating the possible role of exacerbating factor for lupus disease activity.Disclosure of Interests:None declared

scholarly journals Metabolism of the nucleic acids of rumen bacteria by preruminant and ruminant lambs

1981 ◽  
Vol 45 (3) ◽  
pp. 517-527 ◽  
Author(s):  
M. A. Razzaque ◽  
J. H. Topps ◽  
R. N. B. Kay ◽  
J. M. Brockway
Keyword(s):  
Nucleic Acids ◽  
Bacterial Culture ◽  
Total Activity ◽  
Total Radioactivity ◽  
The Other ◽  
Nucleic Acid Content ◽  
Rumen Bacteria ◽  
Total Nucleic Acid ◽  
Purine Base ◽  
Close Relationship

1. A rumen bacterial culture containing specifically labelled nucleic acids was prepared using [8-14C]adenine.2. The labelled preparation was given in a liquid diet to two preruminant lambs and via a rumen tube to two ruminant lambs. The radioactivity excreted in exhaled gases, faeces and urine and that incorporated into tissues was determined.3 The preruminant lambs absorbed 58.3% of the total radioactivity measured after 24 h and the ruminant lambs 66.6% of the total activity measured after 48 h.4. Of the total radioactivity absorbed the preruminant lambs exhaled 38%, excreted 34% in urine and retained 29% in tissues. The corresponding values for the ruminant lambs were 12,41 and 47% respectively.5. There was a close relationship between total nucleic acid content and radioactivity per g of tissues of both preruminant and ruminant lambs.6. Of the radioactivity in the urine, the ruminant and one preruminant lamb excreted most in the fraction containing allantoin, while the other lamb excreted most activity in the uric acid fraction.7. The salvaging of the breakdown products of bacterial nucleic acids to make tissue nucleic acids appears to be an important synthesis in preruminant and ruminant lambs and of the likely precursors the purine base may be more important than the nucleoside.

How Can Economic Interests Influence Support for Free Trade?

2012 ◽  
Vol 66 (2) ◽  
pp. 311-328 ◽  
Author(s):  
Benjamin O. Fordham ◽  
Katja B. Kleinberg
Keyword(s):  
Trade Policy ◽  
Free Trade ◽  
Well Being ◽  
Economic Interests ◽  
Policy Attitudes ◽  
Self Interest ◽  
Close Relationship ◽  
Direction Of Causation ◽  
Complete Account

AbstractRecent research on the sources of individual attitudes toward trade policy comes to very different conclusions about the role of economic self-interest. The skeptical view suggests that long-standing symbolic predispositions and sociotropic perceptions shape trade policy opinions more than one's own material well-being. We believe this conclusion is premature for two reasons. First, the practice of using one attitude to predict another raises questions about direction of causation that cannot be answered with the data at hand. This problem is most obvious when questions about the expected impact of trade are used to predict opinions about trade policy. Second, the understanding of self-interest employed in most studies of trade policy attitudes is unrealistically narrow. In reality, the close relationship between individual economic interests and the interests of the groups in which individuals are embedded creates indirect pathways through which one's position in the economy can shape individual trade policy preferences. We use the data employed by Mansfield and Mutz to support our argument that a more complete account of trade attitude formation is needed and that in such an account economic interests may yet play an important role.1

Gender, Memory, and Identity in the Roman World

2019 ◽  
Keyword(s):  
Roman Empire ◽  
Late Antiquity ◽  
Roman History ◽  
Public And Private ◽  
Imperial Rome ◽  
The Past ◽  
Roman World ◽  
Material Sources ◽  
Close Relationship

This volume approaches three key concepts in Roman history — gender, memory and identity — and demonstrates the significance of their interaction in all social levels and during all periods of Imperial Rome. When societies, as well as individuals, form their identities, remembrance and references to the past play a significant role. The aim of Gender, Memory, and Identity in the Roman World is to cast light on the constructing and the maintaining of both public and private identities in the Roman Empire through memory, and to highlight, in particular, the role of gender in that process. While approaching this subject, the contributors to this volume scrutinise both the literature and material sources, pointing out how widespread the close relationship between gender, memory and identity was. A major aim of Gender, Memory, and Identity in the Roman World as a whole is to point out the significance of the interaction between these three concepts in both the upper and lower levels of Roman society, and how it remained an important question through the period from Augustus right into Late Antiquity.

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