ENDOCRINE CHANGES BEFORE AND AFTER THE MENARCHE

1973 ◽  
Vol 74 (4) ◽  
pp. 685-694 ◽  
Author(s):  
B.-A. Lamberg ◽  
R.-L. Kantero ◽  
P. Saarinen ◽  
O. Widholm
Keyword(s):  
Binding Proteins ◽  
Maturation Process ◽  
Hormone Binding ◽  
Maximal Level ◽  
Continuous Increase ◽  
Mean Values ◽  
Thyroxine Binding Globulin ◽  
Before And After ◽  
Free Thyroxine Index ◽  
Level 1

ABSTRACT In an endocrine survey of healthy girls aged 8 to 20 years before and after the menarche, the serum thyroxine (T4), uptake of triiodothyronine by Sephadex (T3U), and the binding capacities of thyroxine binding globulin (TBG) and pre-albumin (TBPA) were measured, and a free thyroxine index (FTI = T4 × T3U) was calculated. The subjects were grouped according to skeletal age (SA) until the menarche and after this in the post-menarcheal age (PMA), expressed in years. T4 and FTI increased concomitantly and reached peak values of 8.40 μg/100 ml and 8.40, respectively, at 2–3 years PMA. The corresponding mean values for post-menarcheal girls (7.74 μg/100 ml and 7.51) differed statistically significantly from the means before the menarche (7.03 μg/ 100 ml and 6.75). The TBG remained virtually unchanged during the whole period, whereas the TBPA showed a continuous increase and reached a maximal level 1–2 years after the menarche. The maturation process in girls in some way involves an increase in the total and free T4 level which is not dependent on hormone binding proteins.

scholarly journals Concentration of Serum Thyroid Hormone Binding Proteins after 131I Treatment of Hyperthyroidism

1981 ◽  
Vol 18 (4) ◽  
pp. 211-214 ◽  
Author(s):  
John S Harrop ◽  
Malcolm R Hopton ◽  
John H Lazarus
Keyword(s):  
Thyroid Hormone ◽  
Binding Proteins ◽  
Response To Treatment ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Thyroxine Binding Globulin ◽  
131I Treatment ◽  
Before And After ◽  
Hormone Binding Protein ◽  
Serum Thyroid Hormone

Serum concentrations of the thyroid hormone binding proteins, thyroxine binding globulin, prealbumin, and albumin were determined in 30 thyrotoxic patients before and after 131I treatment. Each patient was placed into one of three groups according to response to treatment. The serum concentration of all three proteins rose significantly in 10 patients who became euthyroid, and a greater increase was seen in 10 patients who developed hypothyroidism. There was no significant change in thyroid hormone binding protein concentrations in 10 subjects who remained hyperthyroid. Changes in the concentration of thyroid hormone binding proteins should be borne in mind when total thyroid hormone concentrations are used to monitor the progress of patients receiving treatment for hyperthyroidism.

TRH (Thyroid-Releasing Hormone) Tests

1984 ◽  
Vol 6 (6) ◽  
pp. 189-190
Keyword(s):  
Binding Proteins ◽  
Elevated Serum ◽  
Graves Disease ◽  
Base Line ◽  
Trh Test ◽  
Thyroxine Binding Globulin ◽  
Serum Thyroxine ◽  
Free Thyroxine Index ◽  
Serum T4 ◽  
Line Test

I have read with great interest "Goiter in Children" by Foley (PIR 1984;5:259). The author stated: "In patients with thyromegaly and mild symptoms of hyperthyroidism, a TRH test will help to discriminate hyperthyroxemia secondary to increased or abnormal serum thyroxine binding proteins from early Graves disease, factitious hyperthyroidism, toxic thyroiditis, and TSH-mediated hyperthyroidism." I would suggest the use of a triiodothyronine (T3) resin uptake as a base-line test. An elevated serum thyroxine (T4) value in conjunction with a diminished T3 resin uptake suggests thyroxine-binding globulin (TBG) excess, which can be confirmed by specific quantitation of TBG. Patients with familial dysalbuminemic hyperthyroxinemia (FDH) have elevated levels of serum T4 and free thyroxine index (FT4l) values but normal T3 resin uptake and TBG levels.

Indirect estimation of thyroid hormone-binding proteins to calculate free thyroxine index: comparison of nonisotopic methods that use labeled thyroxine ("T-uptake")

1995 ◽  
Vol 41 (1) ◽  
pp. 41-47 ◽  
Author(s):  
J D Faix ◽  
H N Rosen ◽  
F R Velazquez
Keyword(s):  
Thyroid Hormone ◽  
Binding Proteins ◽  
Free Thyroxine ◽  
Reference Ranges ◽  
Hormone Binding ◽  
Free T4 ◽  
Nonthyroidal Illness ◽  
Free Thyroxine Index ◽  
Uptake Method ◽  
Hypothyroid Patients

Abstract There are many alternative ways of estimating free thyroxine (T4) when thyrotropin screening results are abnormal. In addition to free T4 immunoassays, the menu of most automated immunoassay instruments includes a nonisotopic version of the original triiodothyronine (T3)-uptake assay called "T-uptake." We evaluated the ability of five such assays (Access, ES-300, IMx, Magnum Opus, and Stratus) to accurately estimate the free thyroxine index (FTI) in euthyroid, hyperthyroid, and hypothyroid patients with abnormal concentrations of thyroid hormone-binding proteins, and in patients with nonthyroidal illness. For comparison, we calculated a similar FTI, using either T3-uptake or direct measurement of thyroxine-binding globulin (TBG). Euthyroid reference ranges were comparable. Of euthyroid patients with increased TBG, 12-32% and 5-20% had increased or suppressed FTI, respectively, depending on the T-uptake method used. Except for IMx, 6-35% of hypothyroid patients with increased TBG had inappropriately increased FTI. Patients with nonthyroidal illness had comparable results regardless of the method used, and T-uptake methods were variably affected by known inhibitors of thyroid hormone binding. The most reliable T-uptake method appeared to be the IMx, which, despite claims that it measures all thyroid hormone-binding proteins, correlated best with TBG concentrations.

Oestrogen-like effects of tamoxifen on the concentration of proteins in plasma

1981 ◽  
Vol 97 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Göran Fex ◽  
Göran Adielsson ◽  
Willy Mattson
Keyword(s):  
Plasma Proteins ◽  
Retinol Binding Protein ◽  
Sex Hormone Binding Globulin ◽  
Response To Treatment ◽  
Apolipoprotein Ai ◽  
Hormone Binding ◽  
Thyroxine Binding Globulin ◽  
Pregnancy Zone Protein ◽  
Apparent Relationship ◽  
Before And After

Abstract. The concentrations of 11 plasma proteins were determined by electroimmunoassay in 6 female and one male patient before and after treatment for 1–4 months with tamoxifen (30 mg/day) for advanced cancer. The concentrations of transcortin, sex hormone binding globulin, pregnancy zone protein, apolipoprotein AI and thyroxine binding globulin increased significantly. The concentrations of orosomucoid and haptoglobin decreased significantly. The concentrations of albumin, transferrin, prealbumin and retinol-binding protein showed no significant change. The changes after treatment with tamoxifen were thus similar to those which occur after the administration of oestrogens or during pregnancy although they were quantitatively less pronounced. There were also differences in the pattern of change between treatment with tamoxifen and during pregnancy. There was no apparent relationship between response to treatment and changes in concentration of plasma proteins.

EFFECT OF CLOMIFENE ON THYROID FUNCTION IN NORMAL MEN

1979 ◽  
Vol 90 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Ulla Feldt-Rasmussen ◽  
Axel P. Lange ◽  
John Date ◽  
Mogens Kern Hansen
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Binding Proteins ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Free Thyroxine Index ◽  
Group 2 ◽  
Uptake Test ◽  
Normal Men ◽  
Group 1

ABSTRACT To study the effect on thyroid function 100 mg of clomifene citrate was given once a day to two groups of healthy male volunteers for 5 and 12 consecutive days, respectively. In both groups serum concentrations of TSH, thyroxine, triiodothyronine, T3 resin uptake test and thyroid hormone binding proteins were measured before, during and after oral administration of clomifene. The effect of clomifene treatment was evaluated in Group 1 by means of serum FSH and LH measurements. Further in Group 2 the serum TSH response to iv TRH (200 μg) was also investigated. The mean per cent elevations in serum concentrations of FSH and LH were 145 and 200, respectively. In Group 1 a small but statistically significant decrease within reference limits in triiodothyronine (P < 0.01) and free thyroxine index (P < 0.02) was found on day 4 of clomifene. On day 5 a slight increase in TSH was observed (P < 0.05). In Group 2 the response of TSH to TRH showed a non-significant increase after 5 days and a significant increase (P < 0.01) after 12 days of clomifene. Eight days after discontinuation of the drug the response was restored to normal. No changes in the thyroid hormone binding proteins in serum could be demonstrated. Though the observed changes were slight, they indicate that clomifene exerts an influence directly on the thyroid function.

A Comparison of Serum Thyroxine [T4(D)], RT3U Ratio and T4-RT3 Index with Radioiodine Uptake in the Triiodothyronine Suppression Test

1972 ◽  
Vol 11 (04) ◽  
pp. 317-323
Author(s):  
R. Höschl ◽  
T. M. D. Gimlette
Keyword(s):  
Free Thyroxine ◽  
Radioiodine Uptake ◽  
Serum Thyroxine ◽  
Before And After ◽  
Free Thyroxine Index ◽  
Suppression Test

SummaryA total of 132 triiodothyronine suppression tests were performed using 100 μg of T3 for 7 days. Radioiodine uptake at four hours, serum thyroxine [T4(D)], T3 binding coefficient [RT3U ratio] and free thyroxine index [T4-RT3 index] were estimated before and after a course of triiodothyronine.T4(D) decreased significantly in only 38.4% of T3 suppression tests assessed as positive by the decrease in radioiodine uptake; it did not change or increased significantly in 84.7% of tests negative by radioiodine uptake.RT3U ratio showed little change in all groups. The changes in T4-RT3 index were similar to those of T4(D).The correlation of changes in T4(D) with 4 hour radioiodine uptake is poor (r = 0.34).Agreement between changes in radioiodine uptake and T4(D) was observed only in 54% of tests; between changes in uptake and T4-RT3 index in 69.4%.Estimation of serum thyroxine or free thyroxine index in the T3 suppression test cannot substitute for the radioiodine uptake for reasons which are discussed.

scholarly journals A novel device for detecting anaerobic threshold using sweat lactate during exercise

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuta Seki ◽  
Daisuke Nakashima ◽  
Yasuyuki Shiraishi ◽  
Toshinobu Ryuzaki ◽  
Hidehiko Ikura ◽  
...  
Keyword(s):  
Lactate Threshold ◽  
Ventilatory Threshold ◽  
Recovery Period ◽  
Lactate Concentration ◽  
Continuous Increase ◽  
Mean Values ◽  
Additional Information ◽  
Novel Device ◽  
Mean Differences ◽  
Lactate Sensor

AbstractThe lactate threshold (LT1), which is defined as the first rise in lactate concentration during incremental exercise, has not been non-invasively and conveniently determined in a clinical setting. We aimed to visualize changes in lactate concentration in sweat during exercise using our wearable lactate sensor and investigate the relationship between the lactate threshold (LT1) and ventilatory threshold (VT1). Twenty-three healthy subjects and 42 patients with cardiovascular diseases (CVDs) were enrolled. During exercise, the dynamic changes in lactate values in sweat were visualized in real-time with a sharp continuous increase up to volitional exhaustion and a gradual decrease during the recovery period. The LT1 in sweat was well correlated with the LT1 in blood and the VT1 (r = 0.92 and 0.71, respectively). In addition, the Bland–Altman plot described no bias between the mean values (mean differences: − 4.5 and 2.5 W, respectively). Continuous monitoring of lactate concentrations during exercise can provide additional information for detecting the VT1.

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