scholarly journals Concentration of Serum Thyroid Hormone Binding Proteins after 131I Treatment of Hyperthyroidism

1981 ◽  
Vol 18 (4) ◽  
pp. 211-214 ◽  
Author(s):  
John S Harrop ◽  
Malcolm R Hopton ◽  
John H Lazarus
Keyword(s):  
Thyroid Hormone ◽  
Binding Proteins ◽  
Response To Treatment ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Thyroxine Binding Globulin ◽  
131I Treatment ◽  
Before And After ◽  
Hormone Binding Protein ◽  
Serum Thyroid Hormone

Serum concentrations of the thyroid hormone binding proteins, thyroxine binding globulin, prealbumin, and albumin were determined in 30 thyrotoxic patients before and after 131I treatment. Each patient was placed into one of three groups according to response to treatment. The serum concentration of all three proteins rose significantly in 10 patients who became euthyroid, and a greater increase was seen in 10 patients who developed hypothyroidism. There was no significant change in thyroid hormone binding protein concentrations in 10 subjects who remained hyperthyroid. Changes in the concentration of thyroid hormone binding proteins should be borne in mind when total thyroid hormone concentrations are used to monitor the progress of patients receiving treatment for hyperthyroidism.

ENDOCRINE CHANGES BEFORE AND AFTER THE MENARCHE

1973 ◽  
Vol 74 (4) ◽  
pp. 685-694 ◽  
Author(s):  
B.-A. Lamberg ◽  
R.-L. Kantero ◽  
P. Saarinen ◽  
O. Widholm
Keyword(s):  
Binding Proteins ◽  
Maturation Process ◽  
Hormone Binding ◽  
Maximal Level ◽  
Continuous Increase ◽  
Mean Values ◽  
Thyroxine Binding Globulin ◽  
Before And After ◽  
Free Thyroxine Index ◽  
Level 1

ABSTRACT In an endocrine survey of healthy girls aged 8 to 20 years before and after the menarche, the serum thyroxine (T4), uptake of triiodothyronine by Sephadex (T3U), and the binding capacities of thyroxine binding globulin (TBG) and pre-albumin (TBPA) were measured, and a free thyroxine index (FTI = T4 × T3U) was calculated. The subjects were grouped according to skeletal age (SA) until the menarche and after this in the post-menarcheal age (PMA), expressed in years. T4 and FTI increased concomitantly and reached peak values of 8.40 μg/100 ml and 8.40, respectively, at 2–3 years PMA. The corresponding mean values for post-menarcheal girls (7.74 μg/100 ml and 7.51) differed statistically significantly from the means before the menarche (7.03 μg/ 100 ml and 6.75). The TBG remained virtually unchanged during the whole period, whereas the TBPA showed a continuous increase and reached a maximal level 1–2 years after the menarche. The maturation process in girls in some way involves an increase in the total and free T4 level which is not dependent on hormone binding proteins.

Seasonal Changes in Serum Thyroid Hormone Binding Proteins in the Woodchuck (Marmota monax)*

Endocrinology ◽  
1986 ◽  
Vol 119 (3) ◽  
pp. 967-971 ◽  
Author(s):  
RUTH A. YOUNG ◽  
RAJATA RAJATANAVIN ◽  
LEWIS E. BRAVERMAN ◽  
BUD C. TENNANT
Keyword(s):  
Thyroid Hormone ◽  
Seasonal Changes ◽  
Binding Proteins ◽  
Hormone Binding ◽  
Marmota Monax ◽  
Serum Thyroid Hormone

Oestrogen-like effects of tamoxifen on the concentration of proteins in plasma

1981 ◽  
Vol 97 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Göran Fex ◽  
Göran Adielsson ◽  
Willy Mattson
Keyword(s):  
Plasma Proteins ◽  
Retinol Binding Protein ◽  
Sex Hormone Binding Globulin ◽  
Response To Treatment ◽  
Apolipoprotein Ai ◽  
Hormone Binding ◽  
Thyroxine Binding Globulin ◽  
Pregnancy Zone Protein ◽  
Apparent Relationship ◽  
Before And After

Abstract. The concentrations of 11 plasma proteins were determined by electroimmunoassay in 6 female and one male patient before and after treatment for 1–4 months with tamoxifen (30 mg/day) for advanced cancer. The concentrations of transcortin, sex hormone binding globulin, pregnancy zone protein, apolipoprotein AI and thyroxine binding globulin increased significantly. The concentrations of orosomucoid and haptoglobin decreased significantly. The concentrations of albumin, transferrin, prealbumin and retinol-binding protein showed no significant change. The changes after treatment with tamoxifen were thus similar to those which occur after the administration of oestrogens or during pregnancy although they were quantitatively less pronounced. There were also differences in the pattern of change between treatment with tamoxifen and during pregnancy. There was no apparent relationship between response to treatment and changes in concentration of plasma proteins.

EFFECT OF CLOMIFENE ON THYROID FUNCTION IN NORMAL MEN

1979 ◽  
Vol 90 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Ulla Feldt-Rasmussen ◽  
Axel P. Lange ◽  
John Date ◽  
Mogens Kern Hansen
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Binding Proteins ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Free Thyroxine Index ◽  
Group 2 ◽  
Uptake Test ◽  
Normal Men ◽  
Group 1

ABSTRACT To study the effect on thyroid function 100 mg of clomifene citrate was given once a day to two groups of healthy male volunteers for 5 and 12 consecutive days, respectively. In both groups serum concentrations of TSH, thyroxine, triiodothyronine, T3 resin uptake test and thyroid hormone binding proteins were measured before, during and after oral administration of clomifene. The effect of clomifene treatment was evaluated in Group 1 by means of serum FSH and LH measurements. Further in Group 2 the serum TSH response to iv TRH (200 μg) was also investigated. The mean per cent elevations in serum concentrations of FSH and LH were 145 and 200, respectively. In Group 1 a small but statistically significant decrease within reference limits in triiodothyronine (P < 0.01) and free thyroxine index (P < 0.02) was found on day 4 of clomifene. On day 5 a slight increase in TSH was observed (P < 0.05). In Group 2 the response of TSH to TRH showed a non-significant increase after 5 days and a significant increase (P < 0.01) after 12 days of clomifene. Eight days after discontinuation of the drug the response was restored to normal. No changes in the thyroid hormone binding proteins in serum could be demonstrated. Though the observed changes were slight, they indicate that clomifene exerts an influence directly on the thyroid function.

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