Time course of the effect of streptozotocin on serum concentration of glucose and triglycerides and on hepatic drug metabolism in the male rat

1986 ◽  
Vol 112 (2) ◽  
pp. 300-304 ◽  
Author(s):  
Marion MacFarlane ◽  
Paul Skett
Keyword(s):  
Drug Metabolism ◽  
Time Course ◽  
Serum Glucose ◽  
Male Rat ◽  
Initial Increase ◽  
Liver Protein ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
Serum Parameters ◽  
Cytochrome P 450

Abstract. Streptozotocin (STZ) causes a rise in serum glucose, triglycerides and ketones and a fall in insulin and also leads to changes in drug metabolism. Results from rats left for 20 days indicate that there is no correlation between the effects of STZ on hepatic and serum parameters. The present study investigated the time course of the effect of STZ on hepatic drug metabolism, protein and cytochrome P-450 content and serum glucose and triglyceride concentration. STZ caused the induction of diabetes by 2 h which disappeared at 8 h and reappeared at 24 h. Drug metabolism was reduced after 1 h, returned to control levels at 2 h and remained there until 24 h. Liver protein was increased at 1 and 72 h but cytochrome P-450 was unaffected. The initial increase in serum parameters was not accompanied by changes in hepatic parameters and, thus, the two effects of streptozotocin may not be related.

Vitamin A Status and Hepatic Drug Metabolism in the Rat

1973 ◽  
Vol 51 (1) ◽  
pp. 6-11 ◽  
Author(s):  
G. C. Becking
Keyword(s):  
Vitamin A ◽  
Drug Metabolism ◽  
Vitamin A Deficiency ◽  
Hepatic Drug Metabolism ◽  
Deficient Diet ◽  
Hepatic Drug ◽  
Vitamin A Status ◽  
Cytochrome P 450 ◽  
Liver Vitamin

The effect of vitamin A status on hepatic drug metabolism was studied in rats. Animals were fed diets with and without vitamin A for 20 and 25 days. Weight gains of control and deficient animals were not significantly different, whereas liver vitamin A levels had decreased to less than 10% of control animals after 20 days and were essentially zero after eating the deficient diet for 25 days. Aniline metabolism in vitro and aminopyrine metabolism in vitro and in vivo were significantly lower in male weanling rats fed a vitamin A deficient diet for 20 days. No alteration in in vitro p-nitrobenzoic acid metabolism was noted after 25 days on the test. Vitamin A deficiency did not alter microsomal protein levels or cytochrome c reductase activity but deficient animals did have a lower microsomal cytochrome P-450 content. Hepatic enzyme activities and cytochrome P-450 levels were restored to values approaching those found in control animals by feeding vitamin A deficient rats the vitamin A containing diet for 21 days. Liver vitamin A levels were markedly increased after re-feeding studies but were still significantly lower than control animals.

The role of androgens in the effect of diabetes mellitus on hepatic drug metabolism in the male rat

1984 ◽  
Vol 107 (4) ◽  
pp. 506-512 ◽  
Author(s):  
Paul Skett ◽  
Rosemary A. Cochrane ◽  
Lesley A. Joels
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Drug Metabolism ◽  
Serum Testosterone ◽  
Male Rat ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
Dependent Effect ◽  
Androgen Levels

Abstract. Diabetes mellitus exerts a sex-dependent effect on hepatic drug metabolism in the rat and it has been suggested that this is due to a reduction in serum androgen levels. This study shows that the effect of diabetes is only seen in the presence of androgen and that testosterone can reverse the effect of diabetes on drug metabolism. Diabetes, however, does not consistently cause a reduction in serum testosterone. Diabetes and androgens, therefore, are postulated to interact in their effects on drug metabolism by action on a common mediator. It is suggested that this mediator is growth hormone, which is known to be affected by the androgens and insulin and to be involved in sex differences in drug metabolism in the rat.

Time course of phenobarbital and cimetidine mediated changes in hepatic drug metabolism

1983 ◽  
Vol 25 (2) ◽  
pp. 215-222 ◽  
Author(s):  
M. Døssing ◽  
H. Pilsgaard ◽  
B. Rasmussen ◽  
H. Enghusen Poulsen
Keyword(s):  
Drug Metabolism ◽  
Time Course ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug

Effects of dietary thiamine intake on hepatic drug metabolism in the male rat

1969 ◽  
Vol 18 (9) ◽  
pp. 2288-2292 ◽  
Author(s):  
A.E. Wade ◽  
F.E. Greene ◽  
R.H. Ciordia ◽  
J.S. Meadows ◽  
W.O. Caster
Keyword(s):  
Drug Metabolism ◽  
Male Rat ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug

Evaluation of the involvement of a male specific cytochrome P-450 isozyme in senescence-associated decline of hepatic drug metabolism in male rats

1989 ◽  
Vol 38 (22) ◽  
pp. 3925-3931 ◽  
Author(s):  
Shoichi Fujita ◽  
Reiko Morimoto ◽  
Masato Chiba ◽  
Kenichi Kitani ◽  
Tokuji Suzuki
Keyword(s):  
Drug Metabolism ◽  
Male Rats ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
Male Specific ◽  
Cytochrome P 450

scholarly journals Preventive Effect of a Polyphenol-Rich Extract from Geranium sanguineum L. on Hepatic Drug Metabolism in Influenza Infected Mice

2020 ◽  
Vol 88 (4) ◽  
pp. 45
Author(s):  
Silviya Abarova ◽  
Lyubka Tancheva ◽  
Rumen Nikolov ◽  
Julia Serkedjieva ◽  
Elitsa Pavlova ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Virus Infection ◽  
Medicinal Plant ◽  
Drug Metabolism ◽  
Thiobarbituric Acid ◽  
Hepatic Drug Metabolism ◽  
Preventive Effect ◽  
Thiobarbituric Acid Reactive Substances ◽  
Hepatic Drug ◽  
Hepatic Monooxygenase

The decreased hepatic drug metabolism (predominately first phase) is one of the essential reasons for numerous side effects and for increased drug toxicity during influenza virus infection (IVI). The present study aims to investigate some mechanisms of the preventive effect of a standardized polyphenol complex from the medicinal plant Geranium sanguineum L. (PPhC) (10 mg/kg nasally). A verified experimental model of IVI A/Aichi/2/68 (H3N2) (4.5 lg LD50) in male ICR (Institute of Cancer Research, USA) mice was used. Changes in hepatic monooxygenase activities as well as nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome C reductase activity and cytochtome P450 content were studied on days 2, 6, 9, 21 of the infection together with thiobarbituric acid reactive substances in the liver supernatant. Our data clearly demonstrates that IVI affects all components of the electronic chain of cytochrome P-450. N-demethylases and hydroxylases as well as the activity of cytochrome C reductase and cytochtome P-450 content were decreased in the course of the virus infection. This implies that free radicals play an important role not only in the pathogenesis of IVI, but also in the modulation of the hepatic monooxygenase activity. This is also consistent with the established polyphenol complex PPhC from the medicinal plant Geranium sanguineum L. preventive effect against increased thiobarbituric acid reactive substances (TBARS)-levels. PPhC restored most of the monooxygenase activities that were inhibited in IVI animals, even over the control levels, probably via multiple mechanisms that may entail antioxidant activity and selective antiviral and protein-binding effects. In contrast to infected animals, in healthy mice, PPhC showed moderate reversible inhibitory effect on hepatic monooxygenase activities.

EFFECT OF LOW DOSE CYCLOSPORINE AND SIROLIMUS ON HEPATIC DRUG METABOLISM IN THE RAT1

2001 ◽  
Vol 71 (11) ◽  
pp. 1585-1592 ◽  
Author(s):  
Shuang Bai ◽  
Lane J. Brunner ◽  
Stanislaw M. Stepkowski ◽  
Kimberly L. Napoli ◽  
Barry D. Kahan
Keyword(s):  
Drug Metabolism ◽  
Low Dose ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug

Hepatic Drug Metabolism and Malignancy

JAMA ◽  
1976 ◽  
Vol 236 (14) ◽  
pp. 1612
Author(s):  
Nicholas F. LaRusso
Keyword(s):  
Drug Metabolism ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug
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