Bone morphogenetic protein-7 reduces kidney cold ischemic injury by maintaining epithelial phenotype of tubular cells

2013 ◽  
Author(s):  
Tanja Celic ◽  
Josip Spanjol ◽  
Ivana Maric ◽  
Olga Cvijanovic ◽  
Dragica Bobinac
Keyword(s):  
Bone Morphogenetic Protein ◽  
Ischemic Injury ◽  
Bone Morphogenetic Protein 7 ◽  
Tubular Cells ◽  
Morphogenetic Protein ◽  
Epithelial Phenotype

scholarly journals Loss of Tubular Bone Morphogenetic Protein—7 in Diabetic Nephropathy

2001 ◽  
Vol 12 (11) ◽  
pp. 2392-2399 ◽  
Author(s):  
SHI-NONG WANG ◽  
JANINE LAPAGE ◽  
RAIMUND HIRSCHBERG
Keyword(s):  
Diabetic Nephropathy ◽  
Bone Morphogenetic Protein ◽  
Type I ◽  
Proximal Tubular Cells ◽  
Bone Morphogenetic Protein 7 ◽  
Tubular Cells ◽  
Morphogenetic Protein ◽  
Proximal Tubular ◽  
Bmp Antagonist ◽  
Renal Expression

Abstract. Bone morphogenetic protein—7 (BMP7), a member of the transforming growth factor—β (TGF—β) superfamily of cytokines, is highly expressed in renal tubules and generally promotes maintenance of epithelial phenotype. It was examined whether, during the evolution of experimental diabetic nephropathy, the renal expression of BMP7 and BMP7 receptors declines, and the hypothesis that loss of BMP7 activity is profibrogenic in proximal tubular cells was tested. Moreover,in vitrostudies in cultured proximal tubular cells were performed to examine putative mechanisms that cause these changes. At 15 wk of streptozotocin-induced diabetes, renal expression of BMP7 is declined by about half, and it decreased further by 30 wk to <10% of timed controls. Renal expression of the high-affinity BMP type II receptor and the type I receptor Alk2 (activin receptor—like kinase-2) decreased. Alk3 tended to decrease, but Alk6 remained unchanged. During the evolution of diabetic nephropathy, the secreted BMP antagonist gremlin increased substantially. In cultured tubular cells, TGF-β reduced BMP7 and Alk3 expression and increased gremlin but did not interrupt BMP7-induced activation of smad5 or Erk1 and -2. In contrast, BMP7 did not alter TGF-β expression. Neutralization of endogenous BMP7 in cultured proximal tubular cells raised the expression of fibronectin and tended to increase collagen α1III mRNA levels. In conclusion, in experimental diabetic nephropathy, renal tubular BMP7 and some of its receptors decreased and gremlin, a secreted BMP antagonist, increased. Some, but not all, of these changes are explained by increased TGF-β. The loss of BMP7 activityper seis profibrogenic in tubular cells.

Bone Morphogenetic Protein-7 Reduces Cold Ischemic Injury in Rat Kidney

2011 ◽  
Vol 43 (7) ◽  
pp. 2505-2509 ◽  
Author(s):  
T. Celic ◽  
J. Spanjol ◽  
A. Grskovic ◽  
D. Markic ◽  
I. Prebilic ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Rat Kidney ◽  
Ischemic Injury ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein

A novel Xenopus homologue of bone morphogenetic protein‐7 (BMP‐7)

1997 ◽  
Vol 1 (4) ◽  
pp. 259-271 ◽  
Author(s):  
Shouwen Wang ◽  
Marie Krinks ◽  
Logan Kleinwaks ◽  
Malcolm Moos
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein

Cyclosporine-a induced nephrotoxicity is associated with decreased renal bone morphogenetic protein-7 expression in rats

2004 ◽  
Vol 36 (1) ◽  
pp. 131-133 ◽  
Author(s):  
S Tuğlular ◽  
D Gogas Yavuz ◽  
F Çakalağaoğlu ◽  
L Çıtak ◽  
H Arıkan ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Cyclosporine A ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein

Increased expression of bone morphogenetic protein-7 in bone metastatic prostate cancer

The Prostate ◽  
2003 ◽  
Vol 54 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Hiroshi Masuda ◽  
Yoshitatsu Fukabori ◽  
Katsuya Nakano ◽  
Yutaka Takezawa ◽  
Takanori cSuzuki ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Morphogenetic Protein ◽  
Metastatic Prostate Cancer ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein
Sign in / Sign up

Export Citation Format

Share Document