Change in bone mineral density with high-dose prednisone in patients with rheumatoid arthritis

2016 ◽  
Author(s):  
Linda Rasch ◽  
Tuyl Lilian van ◽  
Martijn Kremer ◽  
Irene Bultink ◽  
Maarten Boers ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
High Dose ◽  
Mineral Density ◽  
Dose Prednisone

OP0106 Change in Bone Mineral Density with High-Dose Prednisone in Patients with Rheumatoid Arthritis: Table 1.

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 95.1-95
Author(s):  
L. Rasch ◽  
L. van Tuyl ◽  
M. Kremer ◽  
I. Bultink ◽  
M. Boers ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
High Dose ◽  
Mineral Density ◽  
Dose Prednisone

The effect of low-dose prednisone on bone mineral density in Peruvian rheumatoid arthritis patients

2003 ◽  
Vol 25 (2) ◽  
pp. 114-117 ◽  
Author(s):  
Cecilia P. Chung ◽  
Anthony S. Russell ◽  
Maria I. Segami ◽  
C�sar A. Ugarte
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Low Dose ◽  
Mineral Density ◽  
Dose Prednisone

Effects of Low-Dose Corticosteroids on the Bone Mineral Density of Patients With Rheumatoid Arthritis

2008 ◽  
Vol 56 (8) ◽  
pp. 1011-1018 ◽  
Author(s):  
Young Ho Lee ◽  
Jin-Hyun Woo ◽  
Seong Jae Choi ◽  
Jong Dae Ji ◽  
Gwan Gyu Song
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Low Dose ◽  
Meta Analysis ◽  
Corticosteroid Treatment ◽  
High Dose ◽  
Mineral Density ◽  
Randomized Controlled Studies

BackgroundThe effects of long-term high-dose corticosteroids on bone mineral density (BMD) are clear, but the effects of low-dose corticosteroids in patients with rheumatoid arthritis (RA) remain controversial. The aim of this study was to assess the effects of low-dose corticosteroids on BMD in patients with RA.MethodsThe authors surveyed randomized controlled studies that examined the effects of low-dose corticosteroids on BMD in patients with RA using MEDLINE and the Cochrane Controlled Trials Register and by performing manual searches. Data were collected on BMD (end-of-period or change-from-baseline) after longest recorded treatment durations. Meta-analysis was performed using a random effects model; outcomes are presented as standardized mean differences (SMDs).ResultsSeven studies were included in this meta-analysis, which included 7 studies on lumbar BMD meta-analysis and 6 studies on femur BMD meta-analysis. Corticosteroids resulted in a moderate worsening in lumbar BMD compared with controls (SMD = −0.483; 95% confidence interval [CI], −0.815 to −0.151, P = 0.004), whereas the femoral BMD differences were not siginificant (SMD = −0.224; 95% CI, −0.663 to 0.215, P = 0.318). Subgroup analysis of BMD data performed on a change-from-baseline basis showed that corticosteroids had a clear effect on both lumbar and femoral BMDs (SMD = −0.354; 95% CI, −0.620 to −0.088, P = 0.009; SMD = −0.488; 95% CI, −0.911 to −0.065, P = 0.024, respectively).ConclusionsThis meta-analysis shows BMD loss after low-dose corticosteroid treatment in patients with RA. These findings have practical implications for the long-term management of patients with RA on low-dose corticosteroids.

scholarly journals Bone turnover, joint damage and bone mineral density in early rheumatoid arthritis treated with combination therapy including high‐dose prednisolone

Rheumatology ◽  
2001 ◽  
Vol 40 (11) ◽  
pp. 1231-1237 ◽  
Author(s):  
A. C. Verhoeven ◽  
M. Boers ◽  
J. M. te Koppele ◽  
W. H. van der Laan ◽  
H. M. Markusse ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Combination Therapy ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Early Rheumatoid Arthritis ◽  
Joint Damage ◽  
High Dose ◽  
Mineral Density

The influence of the 24-month treatment with anti-CD20 antibodies (rituximab) on bone mineral density in patients with rheumatoid arthritis

2014 ◽  
Author(s):  
Polina Dydykina ◽  
Irina Dydykina ◽  
Anna Devyataikina ◽  
Galina Lukina ◽  
Alexandr Smirnov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Anti Cd20 ◽  
Cd20 Antibodies

FRI0077 Factors Predicting Change in Bone Mineral Density in Patients with Rheumatoid Arthritis: the Tomorrow Study: Table 1

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 409.1-409
Author(s):  
M. Tada ◽  
T. Koike ◽  
K. Inui ◽  
Y. Sugioka ◽  
K. Mamoto ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals P129 Predictors of low bone mineral density in rheumatoid arthritis

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Malika A Swar ◽  
Marwan Bukhari
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Bone Mineral Density ◽  
Family History ◽  
Bone Loss ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Fragility Fracture ◽  
Mineral Density ◽  
History Of

Abstract Background/Aims  Osteoporosis (OP) is an extra-articular manifestation of rheumatoid arthritis (RA) that leads to increased fracture susceptibility due to a variety of reasons including immobility and cytokine driven bone loss. Bone loss in other populations has well documented risk factors. It is unknown whether bone loss in RA predominantly affects the femoral neck or the spine. This study aimed to identify independent predictors of low bone mineral density (BMD) in patients RA at the lumbar spine and the femoral neck. Methods  This was a retrospective observational cohort study using patients with Rheumatoid arthritis attending for a regional dual X-ray absorptiometry (DEXA) scan at the Royal Lancaster Infirmary between 2004 and 2014. BMD in L1-L4 in the spine and in the femoral neck were recorded. The risk factors investigated were steroid use, family history of osteoporosis, smoking, alcohol abuse, BMI, gender, previous fragility fracture, number of FRAX(tm) risk factors and age. Univariate and Multivariate regression analysis models were fitted to explore bone loss at these sites using BMD in g/cm2 as a dependant variable. . Results  1,527 patients were included in the analysis, 1,207 (79%) were female. Mean age was 64.34 years (SD11.6). mean BMI was 27.32kg/cm2 (SD 5.570) 858 (56.2%) had some steroid exposure . 169(11.1%) had family history of osteoporosis. fragility fracture history found in 406 (26.6%). 621 (40.7%) were current or ex smokers . There was a median of 3 OP risk factors (IQR 1,3) The performance of the models is shown in table one below. Different risk factors appeared to influence the BMD at different sites and the cumulative risk factors influenced BMD in the spine. None of the traditional risk factors predicted poor bone loss well in this cohort. P129 Table 1:result of the regression modelsCharacteristicB femoral neck95% CIpB spine95%CIpAge at scan-0.004-0.005,-0.003<0.01-0.0005-0.002,0.00050.292Sex-0.094-0.113,-0.075<0.01-0.101-0.129,-0.072<0.01BMI (mg/m2)0.0080.008,0.0101<0.010.01130.019,0.013<0.01Fragility fracture-0.024-0.055,0.0060.12-0.0138-0.060,0.0320.559Smoking0.007-0.022,0.0350.650.0286-0.015,0.0720.20Alcohol0.011-0.033,0.0 5560.620.0544-0.013,0.1120.11Family history of OP0.012-0.021,0.0450.470.0158-0.034,0.0650.53Number of risk factors-0.015-0.039,0.0080.21-0.039-0.075,-0.0030.03steroids0.004-0.023,0.0320.030.027-0.015,0.0690.21 Conclusion  This study has shown that predictors of low BMD in the spine and hip are different and less influential than expected in this cohort with RA . As the FRAX(tm) tool only uses the femoral neck, this might underestimate the fracture risk in this population. Further work looking at individual areas is ongoing. Disclosure  M.A. Swar: None. M. Bukhari: None.

IgA rheumatoid factor is associated with bone mineral density preservation in rheumatoid arthritis

2021 ◽  
Author(s):  
Rim Sghiri ◽  
Asma Boumiza ◽  
Hana Benhassine ◽  
Nejla Elamri ◽  
Zahid Shakoor ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Rheumatoid Factor ◽  
Bone Mineral ◽  
Mineral Density
Sign in / Sign up

Export Citation Format

Share Document