Effects of the FGF2 aptamer on growth plate cartilage development of achondroplasia patient-specific iPS cells in a xenograft model

2019 ◽  
Author(s):  
Takeshi Kimura ◽  
Kie Yasuda ◽  
Yukako Nakano ◽  
Shinji Takeyari ◽  
Yasuji Kitabatake ◽  
...  
Keyword(s):  
Growth Plate ◽  
Xenograft Model ◽  
Ips Cells ◽  
Patient Specific ◽  
Growth Plate Cartilage ◽  
Cartilage Development

scholarly journals Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia

2018 ◽  
Vol 26 (11) ◽  
pp. 1551-1561 ◽  
Author(s):  
T. Kimura ◽  
T. Ozaki ◽  
K. Fujita ◽  
A. Yamashita ◽  
M. Morioka ◽  
...  
Keyword(s):  
Growth Plate ◽  
Specific Growth ◽  
Xenograft Model ◽  
Patient Specific ◽  
Growth Plate Cartilage

Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development

2013 ◽  
Vol 13 (3-4) ◽  
pp. 84-90 ◽  
Author(s):  
Hisashi Ideno ◽  
Akemi Shimada ◽  
Kazuhiko Imaizumi ◽  
Hiroshi Kimura ◽  
Masumi Abe ◽  
...  
Keyword(s):  
Growth Plate ◽  
Hypertrophic Chondrocytes ◽  
Growth Plate Cartilage ◽  
Cartilage Development ◽  
Predominant Expression

scholarly journals Tissue Engineering Models of Human Digits: Effect of Periosteum on Growth Plate Cartilage Development

2008 ◽  
Vol 189 (1-4) ◽  
pp. 241-244 ◽  
Author(s):  
William J. Landis ◽  
Robin Jacquet ◽  
Elizabeth Lowder ◽  
Mitsuhiro Enjo ◽  
Yoshitaka Wada ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Plate ◽  
Growth Plate Cartilage ◽  
Cartilage Development ◽  
Engineering Models

In situ localization of lectin-binding glycoconjugates in the matrix of growth-plate cartilage

1986 ◽  
Vol 176 (1) ◽  
pp. 65-82 ◽  
Author(s):  
Cornelia E. Farnum ◽  
Norman J. Wilsman
Keyword(s):  
Growth Plate ◽  
Lectin Binding ◽  
Growth Plate Cartilage ◽  
The Matrix

scholarly journals Biodistribution and internal radiation dosimetry of a companion diagnostic radiopharmaceutical, [68Ga]PSMA-11, in subcutaneous prostate cancer xenograft model mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Su Bin Kim ◽  
In Ho Song ◽  
Yoo Sung Song ◽  
Byung Chul Lee ◽  
Arun Gupta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Dosimetry ◽  
Xenograft Model ◽  
Absorbed Dose ◽  
Patient Specific ◽  
Internal Radiation ◽  
Washout Phase ◽  
Heterogeneous Tissue ◽  
Organ Level ◽  
Reported Data

Abstract[68Ga]PSMA-11 is a prostate-specific membrane antigen (PSMA)-targeting radiopharmaceutical for diagnostic PET imaging. Its application can be extended to targeted radionuclide therapy (TRT). In this study, we characterize the biodistribution and pharmacokinetics of [68Ga]PSMA-11 in PSMA-positive and negative (22Rv1 and PC3, respectively) tumor-bearing mice and subsequently estimated its internal radiation dosimetry via voxel-level dosimetry using a dedicated Monte Carlo simulation to evaluate the absorbed dose in the tumor directly. Consequently, this approach overcomes the drawbacks of the conventional organ-level (or phantom-based) method. The kidneys and urinary bladder both showed substantial accumulation of [68Ga]PSMA-11 without exhibiting a washout phase during the study. For the tumor, a peak concentration of 4.5 ± 0.7 %ID/g occurred 90 min after [68Ga]PSMA-11 injection. The voxel- and organ-level methods both determined that the highest absorbed dose occurred in the kidneys (0.209 ± 0.005 Gy/MBq and 0.492 ± 0.059 Gy/MBq, respectively). Using voxel-level dosimetry, the absorbed dose in the tumor was estimated as 0.024 ± 0.003 Gy/MBq. The biodistribution and pharmacokinetics of [68Ga]PSMA-11 in various organs of subcutaneous prostate cancer xenograft model mice were consistent with reported data for prostate cancer patients. Therefore, our data supports the use of voxel-level dosimetry in TRT to deliver personalized dosimetry considering patient-specific heterogeneous tissue compositions and activity distributions.

scholarly journals Influence of intermittent compressive force on proteoglycan content in calcifying growth plate cartilage in vitro.

1987 ◽  
Vol 262 (32) ◽  
pp. 15490-15495
Author(s):  
J Klein-Nulend ◽  
J P Veldhuijzen ◽  
R J van de Stadt ◽  
G P van Kampen ◽  
R Kuijer ◽  
...  
Keyword(s):  
Growth Plate ◽  
Compressive Force ◽  
Growth Plate Cartilage ◽  
Proteoglycan Content

scholarly journals Endogenous Retinoids in Mammalian Growth Plate Cartilage

2010 ◽  
Vol 285 (47) ◽  
pp. 36674-36681 ◽  
Author(s):  
Julie A. Williams ◽  
Maureen Kane ◽  
Takahiro Okabe ◽  
Motomi Enomoto-Iwamoto ◽  
Joseph L. Napoli ◽  
...  
Keyword(s):  
Growth Plate ◽  
Growth Plate Cartilage
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