scholarly journals Longitudinal analyses of the steroid metabolome in obese PCOS girls with weight loss

2017 ◽  
Vol 6 (4) ◽  
pp. 213-224 ◽  
Author(s):  
Thomas Reinehr ◽  
Alexandra Kulle ◽  
Juliane Rothermel ◽  
Caroline Knop-Schmenn ◽  
Nina Lass ◽  
...  
Keyword(s):  
Weight Loss ◽  
Steroid Hormones ◽  
Weight Status ◽  
Polycystic Ovarian Syndrome ◽  
Longitudinal Analyses ◽  
Steroid Profiling ◽  
Underlying Mechanisms ◽  
17 Hydroxyprogesterone ◽  
One Year ◽  
Ovarian Syndrome

Objective The underlying mechanisms of polycystic ovarian syndrome (PCOS) are not fully understood yet. The aim of the study was to get functional insights into the regulation of steroid hormones in PCOS by steroid metabolomics. Design This is a longitudinal study of changes of steroid hormones in 40 obese girls aged 13–16 years (50% with PCOS) participating in a 1-year lifestyle intervention. Girls with and without PCOS were matched to age, BMI and change of weight status. Methods We measured progesterone, 17-hydroxyprogesterone, 17-hydroxyprogenolon, 11-deoxycorticosterone, 21-deoxycorticosterone, deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, cortisone, androstenedione, testosterone, dehydroepiandrostendione-sulfate (DHEA-S), estrone and estradiol by LC–MS/MS steroid profiling at baseline and one year later. Results At baseline, obese PCOS girls demonstrated significantly higher androstenedione and testosterone concentrations compared to obese girls without PCOS, whereas the other steroid hormones including glucocorticoids, mineralocorticoids, estrogens and precursors of androgens did not differ significantly. Weight loss in obese PCOS girls was associated with a significant decrease of testosterone, androstenedione, DHEA-S, cortisol and corticosterone concentrations. Weight loss in obese non-PCOS girls was associated with a significant decrease of DHEA-S, cortisol and corticosterone concentrations, whereas no significant changes of testosterone and androstenedione concentrations could be observed. Without weight loss, no significant changes of steroid hormones were measured except an increase of estradiol in obese PCOS girls without weight loss. Conclusions The key steroid hormones in obese adolescents with PCOS are androstenedione and testosterone, whereas glucocorticoids, mineralocorticoids, estrogens and precursors of androgens did not differ between obese girls with and without PCOS.

Sleeve Gastrectomy for Obesity in Polycystic Ovarian Syndrome: Weight Loss and Fertility Outcomes

2017 ◽  
Vol 13 (10) ◽  
pp. S15 ◽  
Author(s):  
Joshua Dilday ◽  
Michael Derickson ◽  
John Kuckelman ◽  
Julia Bader ◽  
Eric Ahnfeldt ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

Weight loss in obese girls with polycystic ovarian syndrome is associated with a decrease in Anti-Muellerian Hormone concentrations

2017 ◽  
Vol 87 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Thomas Reinehr ◽  
Alexandra Kulle ◽  
Juliane Rothermel ◽  
Caroline Knop ◽  
Nina Lass ◽  
...  
Keyword(s):  
Weight Loss ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

Weight Status Of Females One Year After A 12-week Worksite Weight Loss Intervention

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S171
Author(s):  
Jeremy T. Barnes ◽  
Craig L. Elder ◽  
Thomas J. Pujol
Keyword(s):  
Weight Loss ◽  
Weight Status ◽  
Weight Loss Intervention ◽  
One Year

Longitudinal analyses of polysomnographic variables, serum androgens, and parameters of glucose metabolism in obese adolescents with polycystic ovarian syndrome

2011 ◽  
Vol 16 (4) ◽  
pp. 1139-1146 ◽  
Author(s):  
Gideon de Sousa ◽  
Bernhard Schlüter ◽  
Thomas Menke ◽  
Eckardt Trowitzsch ◽  
Werner Andler ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Polycystic Ovarian Syndrome ◽  
Longitudinal Analyses ◽  
Obese Adolescents ◽  
Serum Androgens ◽  
Ovarian Syndrome

scholarly journals Effect of Exercise and Weight Loss in Polycystic Ovarian Syndrome among Obese Women

2021 ◽  
Vol 29 (S1) ◽  
Author(s):  
Thomas Cochrane ◽  
Tengku Fadilah Tengku-Kamalden ◽  
Rachel Davey ◽  
Roxana Dev Omar Dev
Keyword(s):  
Heart Rate ◽  
Weight Loss ◽  
Body Weight ◽  
Polycystic Ovarian Syndrome ◽  
Intervention Group ◽  
Small Sample ◽  
Lean Body Weight ◽  
Obese Women ◽  
Fat Percentage ◽  
Ovarian Syndrome

Ovulation and fertility can be improved by weight loss in obese women with Polycystic Ovarian Syndrome (PCOS). The aim of this study was to investigate the effectiveness of a twelve-week supervised exercise program in combination with dietary restrictions for obese women with PCOS. The study is a quasi-experimental research and used an experimental pre- and post-test design. Fifteen women recruited from Fertility Clinic, Jessops Hospital for Women, Sheffield took part in this study. Respiratory exchange ratio (RER), heart rate, perceived exertion (RPE), and Houston non-exercise activity code were recorded. Height, weight, and body girth measurements were taken to calculate body mass index, fat percentage, and lean body weight. The intervention group lost an average of 3.1 kg and gained 3.45 kg of lean body weight. Loss of fat percentage was 12.1%. No significant difference was found in the control group. The RER and heart rate value decreased for the same workload in the intervention group, indicating higher tolerance towards exercise intensity. However, the changes for both groups were not significant. The average group compliance rate was 53% (at least two sessions per week). Bearing in mind the small sample size (n=4) for control, the improvement in fitness, significant weight loss, and body composition change (increase in fat-free mass) was achieved in this study. Twelve weeks of exercise, combined with dietary advice, were sufficient to benefit PCOS obese women. The research has achieved a commendable weight-loss objective and has demonstrated increases in standards of fitness among obese women.

scholarly journals 11-Keto-testosterone and Other Androgens of Adrenal Origin

2020 ◽  
pp. S187-S192
Author(s):  
L. STÁRKA ◽  
M. DUŠKOVÁ ◽  
J. VÍTKŮ
Keyword(s):  
Prostate Cancer ◽  
Steroid Hormones ◽  
Polycystic Ovarian Syndrome ◽  
Adrenal Glands ◽  
Clinical Importance ◽  
Androgen Deprivation ◽  
Adrenal Hyperplasia ◽  
Androgenic Activity ◽  
Area Of Concern ◽  
Ovarian Syndrome

The adrenal glands produce significant amounts of steroid hormones and their metabolites, with various levels of androgenic activities. Until recently, the androgenic potency of these adrenal-derived compounds were not well known, but some recent studies have shown that the production of 11-oxo- and 11β-hydroxy-derived testosterone and dihydrotestosterone evidently have high androgenic activity. This fact has clinical importance, for instance, in various types of congenital adrenal hyperplasia with androgenization or polycystic ovarian syndrome, and laboratory determinations of these substances could help to better evaluate the total androgen pressure in patients with these disorders. Another area of concern is the treatment of prostate cancer with androgen deprivation, which loses effectiveness after a certain time. The concurrent blocking of the secretion of adrenal C19-steroids, whether using corticoids or adrenostatics, could increase the effectiveness of androgen-deprivation therapy.

scholarly journals Characterization of Intrafollicular Steroid Hormones, Inhibin, and Follistatin in Women with and without Polycystic Ovarian Syndrome Following Gonadotropin Hyperstimulation1

1997 ◽  
Vol 57 (5) ◽  
pp. 1211-1216 ◽  
Author(s):  
Geralyn Lambert-Messerlian ◽  
Ann Taylor ◽  
Lucy Leykin ◽  
Keith Isaacson ◽  
Thomas Toth ◽  
...  
Keyword(s):  
Steroid Hormones ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome
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