scholarly journals The value of SPECT/CT imaging of lacrimal glands as a means of assessing the activity of Graves’ orbitopathy

2022 ◽  
Author(s):  
Ruxuan Zhao ◽  
Ting-Ting Shi ◽  
Sha Luo ◽  
Yun-Fu Liu ◽  
Zhong Xin ◽  
...  

Background: Graves’ orbitopathy (GO) is an autoimmune disease with mechanical impairment of orbital muscles and lacrimal gland dysfunction. The frequently used methods of assessing GO activity include: Clinical Activity Score (CAS), computed tomography (CT), and magnetic resonance imaging (MRI). These approaches are mainly associated with orbital muscles, however, there are not many studies that focus on the lacrimal gland inflammation of GO patients. Objective: The aim of this study is to assess the usefulness of 99mTc-DTPA SPECT/CT in evaluating the lacrimal gland inflammation in Graves orbitopathy, as compared with other methods. Methods: A retrospective analysis of 48 patients with active GO compared with 33 controls was conducted. All subjects underwent clinical-endocrinological analyses, CAS evaluation, CT scans, and SPECT/CT examination. Lacrimal gland dimensions were determined and analyzed. Results: The lacrimal glands in patients with GO were significantly larger in all measured dimensions (p < 0.001) on CT scans relative to those in controls. Increased lacrimal gland DTPA uptake ratios (p < 0.001) were displayed in active GO patients compared to controls and were also correlated with TRAb levels. The cut-off value for discriminating active and inactive disease was calculated to be 1.735, with specificity of 82.6% and sensitivity of 74.2%. SPECT/CT uptake ratios and CAS values were positively correlated in all GO patients. SPECT/CT uptake ratios were also positively correlated with CT measurements including lacrimal gland volume and coronal width in GO patients. Conclusions: These data indicated that lacrimal gland SPECT/CT images can serve as a good tool for assessing the inflammation and disease activity of GO.

2009 ◽  
Vol 33 (2) ◽  
pp. 311 ◽  
Author(s):  
Owen M Bradfield

Twelve months ago, the Australian Medical Association (AMA) called upon the Federal Labor Government to implement a previous coalition policy allowing general practitioners to directly refer patients for magnetic resonance imaging (MRI) scans of the knee and brain. To support their position, the AMA commissioned a University of Sydney report evaluating the health care and economic outcomes of the policy. The AMA reported that the results supported the policy and would result in a $42 million saving from fewer computed tomography (CT) scans and fewer specialist referrals and consultations. Arguably, this was not an accurate portrayal of the results. Further research is needed, and ongoing dialogue with radiologists and other key stakeholders is urged, to ensure that access to MRI facilities will continue to meet future demand and that GPs will be adequately trained in utilising MRI services.


2021 ◽  
Author(s):  
Yue-Yue Wang ◽  
Qian Wu ◽  
Lu Chen ◽  
Wen Chen ◽  
Tao Yang ◽  
...  

Purpose: To evaluate the value of magnetic resonance imaging (MRI)-based texture analysis of extraocular muscle (EOM) and orbital fat (OF) in monitoring and predicting the response to glucocorticoid (GC) therapy in patients with thyroid-associated ophthalmopathy (TAO). Methods: Thirty-seven active and moderate-to-severe TAO patients (responders, n=23; unresponders, n=14) were retrospectively enrolled. MRI-based texture parameters (entropy, uniformity, skewness and kurtosis) of EOM and OF were measured before and after GC therapy, and compared between groups. Correlations between the changes of clinical activity score (CAS) and imaging parameters before and after treatment were assessed. Receiver operating characteristic curves were used to evaluate the predictive value of identified variables. Results: Responsive TAOs showed significantly decreased entropy and increased uniformity at EOM and OF after GC therapy (p<0.01), while unresponders showed no significance. Changes of entropy and uniformity at EOM and OF were significantly correlated with changes of CAS before and after treatment (p<0.05). Responders showed significantly lower entropy and higher uniformity at EOM than unresponders before treatment (p<0.01). Entropy and uniformity of EOM and disease duration were identified as independent predictors for responsive TAOs. Combination of all three variables demonstrated optimal efficiency (area under curve, 0.802) and sensitivity (82.6%), and disease duration alone demonstrated optimal specificity (100%) for predicting responsive TAOs. Conclusion: MRI-based texture analysis can reflect histopathological heterogeneity of orbital tissues. It could be useful for monitoring and predicting the response to GC in TAO patients.


Vascular ◽  
2011 ◽  
Vol 19 (6) ◽  
pp. 346-350 ◽  
Author(s):  
Viviane Kazan ◽  
Tahir Jamil ◽  
Rahma Beyrouti ◽  
Munier Nazzal

Atherosclerotic abdominal aortic ulcers are uncommon in contrast to those of the thoracic aorta. They present with a variety of symptoms. Computed tomography (CT) scans and magnetic resonance imaging (MRI) are the methods of diagnosis. Treatment is made easier with the use of endovascular techniques, which have less mortality and morbidity than open repair. In this paper, we present three cases of penetrating aortic ulcers presenting with abdominal pain. In two of those cases, the diagnosis was made by MRI and missed by CT scan. We present a review of the literature.


2021 ◽  
Vol 14 (02) ◽  
pp. 97-102
Author(s):  
Virda Maharani ◽  
Arie Utariani ◽  
Lucky Andriyanto ◽  
Bambang Harjono

Background: Magnetic Resonance Imaging (MRI) and Computerized Tomography (CT) Scans might be challenging for children or patients with anxiety or claustrophobia. The use of general anesthesia aims to increase the success rate, but inadequate management can result in longer length of stay. Purpose: To analyze patients' length of stay on MRI and CT-scan with intravenous anesthesia. Methods: A descriptive observational study. The datas were collected retrospectively from the medical records in General Diagnostic Center. Total of 721 patients who underwent MRI or CT Scan procedures with intravenous anesthesia during 2017-2018. The data obtained were patients' age, sex, the type of procedure, physical status, comorbid, type of anesthesia drug, diagnostic procedure duration, length of observation in the Post Anesthesia Care Unit (PACU), and overall length of stay. Results: All MRI procedures used midazolam-propofol combination, and only one CT scan procedure used this combination, while the other used only propofol. Patients undergoing MRI had length of stay with a mean duration of 6,6,3±1,26 hours, compared to CT scans with 5,20 ±1,38 hours, due to the more prolonged procedure and observation duration in the PACU. Conclusion: Patients undergoing MRI had a longer length of stay than the ones doing CT scans.


2006 ◽  
Vol 121 (2) ◽  
pp. 105-109 ◽  
Author(s):  
C C Chan ◽  
D E Saunders ◽  
W K Chong ◽  
B E Hartley ◽  
E Raglan ◽  
...  

Objective: To assess whether lateral semicircular canal (LSCC) ossification is more advanced than that in the cochlear basal turn, in order to judge the value of the former as a predictor.Methods: Retrospective review of 33 paediatric patients from our cochlear implant programme, with profound sensorineural hearing loss after bacterial meningitis. Magnetic resonance imaging (MRI), computed tomography (CT) scans and operative findings were reviewed.Results: On CT, LSCC ossification scores were more advanced than those for the cochlear basal turn in 69.9 per cent of implanted ears. Forty-five per cent (15/33) of children had ossification at surgery. In predicting this, the sensitivity of CT LSCC ossification was 90 per cent and that of MRI LSCC ossification was 83.3 per cent.Conclusions: The more advanced ossification found in the LSCC, compared with that in the cochlear basal turn, adds to previous findings of LSCC pathology predicting cochlear ossification. Surprisingly, CT of the LSCC appears to be no less valuable than MRI in pre-operative cochlear implant assessment of post-meningitic children.


2019 ◽  
Vol 23 (04) ◽  
pp. 405-418 ◽  
Author(s):  
James F. Griffith ◽  
Radhesh Krishna Lalam

AbstractWhen it comes to examining the brachial plexus, ultrasound (US) and magnetic resonance imaging (MRI) are complementary investigations. US is well placed for screening most extraforaminal pathologies, whereas MRI is more sensitive and accurate for specific clinical indications. For example, MRI is probably the preferred technique for assessment of trauma because it enables a thorough evaluation of both the intraspinal and extraspinal elements, although US can depict extraforaminal neural injury with a high level of accuracy. Conversely, US is probably the preferred technique for examination of neurologic amyotrophy because a more extensive involvement beyond the brachial plexus is the norm, although MRI is more sensitive than US for evaluating muscle denervation associated with this entity. With this synergy in mind, this review highlights the tips for examining the brachial plexus with US and MRI.


Endoscopy ◽  
2004 ◽  
Vol 36 (10) ◽  
Author(s):  
BP McMahon ◽  
JB Frøkjær ◽  
A Bergmann ◽  
DH Liao ◽  
E Steffensen ◽  
...  

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