Normal health-related quality of life can be achieved in patients with functional pituitary adenomas having surgery as primary treatment

2014 ◽  
Author(s):  
Elina Ritvonen ◽  
Atte Karppinen ◽  
Satu Vehkavaara ◽  
Risto Roine ◽  
Harri Sintonen ◽  
...  
2014 ◽  
Vol 82 (3) ◽  
pp. 412-421 ◽  
Author(s):  
Elina Ritvonen ◽  
Atte Karppinen ◽  
Harri Sintonen ◽  
Satu Vehkavaara ◽  
Leena Kivipelto ◽  
...  

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 39-39
Author(s):  
Nicholas RIchard Cnossen ◽  
Amber Gail Orman ◽  
Deukwoo Kwon ◽  
Chad Ritch ◽  
Mark Gonzalgo ◽  
...  

39 Background: Health-related quality of life (HRQoL) outcomes are important in treatment selection for prostate cancer. The Expanded Prostate Cancer Index Composite (EPIC) is a validated and widely-utilized HRQoL survey which accounts for newer radiotherapeutic, surgical, and hormonal treatment methods. We present a meta-analysis of patient reported HRQoL outcomes collected with EPIC and compare HRQoL trends with radiation therapy, surgery, or active surveillance as primary treatment. Methods: The PubMed database was systematically searched for all studies which presented data directly derived from the use of EPIC on patients with prostate cancer prior to 07/09/2014. All eligible studies were selected for either inclusion and analysis or exclusion based on pre-determined criteria. The data from included studies was compiled and a simulation-based estimation method using Approximate Bayesian Computation was performed to obtain missing standard deviation estimate. A longitudinal meta-analysis was conducted to estimate EPIC-profiles for each component using Bayesian p-spline method. Results: Over 4,000 studies were searched, 152 were deemed eligible, and 39 were included. The calculated mean summary score estimates are shown in the attached table. Conclusions: In the urinary domain, radical prostatectomy (RP) has lower acute scores than active surveillance (AS) or radiation therapy (RT) without long-term difference. In the bowel domain, RT has lower scores than AS or RP acutely and long-term. In the sexual domain, RT and RP have lower acute scores than AS. RP has lower scores than RT without long-term difference. In the hormonal domain, little difference was noted between modalities. [Table: see text]


2015 ◽  
Vol 68 (4) ◽  
pp. 600-608 ◽  
Author(s):  
Sanoj Punnen ◽  
Janet E. Cowan ◽  
June M. Chan ◽  
Peter R. Carroll ◽  
Matthew R. Cooperberg

2015 ◽  
Vol 84 (4) ◽  
pp. 532-539 ◽  
Author(s):  
Atte Karppinen ◽  
Elina Ritvonen ◽  
Risto Roine ◽  
Harri Sintonen ◽  
Satu Vehkavaara ◽  
...  

Author(s):  
Pichitra Lekdamrongkul ◽  
Kanaungnit Pongthavornkamol ◽  
Alex Molassiotis ◽  
Aurawamon Sriyuktasuth ◽  
Noppadol Siritanaratkul ◽  
...  

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