Non-alcoholic fatty liver disease and polycystic ovarian syndrome in lean and obese women of reproductive age

2018 ◽  
Author(s):  
Athina Markou ◽  
Krystallenia Alexandraki ◽  
Evita Kafritsa ◽  
Ioannis Androulakis ◽  
Vasiliki Syriou ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Polycystic Ovarian Syndrome ◽  
Reproductive Age ◽  
Obese Women ◽  
Women Of Reproductive Age ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Ovarian Syndrome

scholarly journals Association of non-alcoholic fatty liver disease and polycystic ovarian syndrome

2020 ◽  
Vol 7 (1) ◽  
pp. e000352 ◽  
Author(s):  
Mohammad Maysara Asfari ◽  
Muhammad Talal Sarmini ◽  
Firas Baidoun ◽  
Yasser Al-Khadra ◽  
Yamen Ezzaizi ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Polycystic Ovarian Syndrome ◽  
National Database ◽  
Multivariate Logistic Regression ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Ovarian Syndrome

BackgroundPolycystic ovarian syndrome (PCOS) is a common endocrine disorder in women. Women with PCOS have androgen excess as a defining feature. They also have increased insulin resistance and obesity, which are also risk factors for non-alcoholic fatty liver disease (NAFLD). However, published data regarding PCOS as independent risk factor for NAFLD remain controversial. Therefore, we conducted this study to evaluate the association between PCOS and NAFLD using a large national database.MethodsWe identified adult female patients (≥18 years) with PCOS using the National Inpatient Sample database between 2002 and 2014. The control group included patients who did not have a diagnosis of PCOS. Multivariate logistic regression analysis was performed to study the association of NAFLD with PCOS.ResultsOut of a total of 50 785 354 women, 77 415 (0.15%) had PCOS. These patients were younger (32.7 vs 54.8; p<0.001) and more likely to be obese (29.4% vs 8.6%; p<0.001) compared with non-PCOS patients. However, the PCOS group had less hypertension (23.2% vs 39.8%), dyslipidaemia (12% vs 17.8%) and diabetes mellitus (18.1% vs 18.3%) (p<0.001 for all). Using multivariate logistic regression, patients with PCOS had significantly higher rate of NAFLD (OR 4.30, 95% CI 4.11 to 4.50, p<0.001).ConclusionOur study showed that patients with PCOS have four times higher risk of developing NAFLD compared with women without PCOS. Further studies are needed to assess if specific PCOS treatments can affect NAFLD progression.

scholarly journals Are Women With Polycystic Ovarian Syndrome at a High Risk of Non-Alcoholic Fatty Liver Disease? A Meta-Analysis

2014 ◽  
Vol 14 (11) ◽  
Author(s):  
Mahdi Ramezani Binabaj ◽  
Mohsen Motalebi ◽  
Hamid Karimi-Sari ◽  
Mohammad Saeid Rezaee Zavareh ◽  
Seyed Moayed Alavian
Keyword(s):  
Liver Disease ◽  
High Risk ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Ovarian Syndrome
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