Comparison of metabolic parameters between women with autoimmune thyroiditis on levothyroxine replacement therapy and euthyroid healthy women

2021 ◽  
Author(s):  
Antoaneta Argatska ◽  
Boyan Nonchev
Keyword(s):  
Replacement Therapy ◽  
Autoimmune Thyroiditis ◽  
Metabolic Parameters ◽  
Healthy Women ◽  
Levothyroxine Replacement

scholarly journals Long-Term Cardiovascular Effects of Levothyroxine Therapy in Young Adults with Congenital Hypothyroidism

2008 ◽  
Vol 93 (7) ◽  
pp. 2486-2491 ◽  
Author(s):  
Mariacarolina Salerno ◽  
Ugo Oliviero ◽  
Teresa Lettiero ◽  
Vincenzo Guardasole ◽  
Dario Maria Mattiacci ◽  
...  
Keyword(s):  
Young Adults ◽  
Replacement Therapy ◽  
Exercise Capacity ◽  
Congenital Hypothyroidism ◽  
Intima Media Thickness ◽  
Normal Range ◽  
Levothyroxine Replacement ◽  
Levothyroxine Treatment ◽  
Tsh Levels

Abstract Context: Congenital hypothyroidism (CH) is the most prevalent endocrine disorder in the newborn and is routinely treated with life-long levothyroxine replacement therapy. Although several studies have demonstrated that such therapy may impact on the cardiovascular system, little is known with regard to the effects of long-term levothyroxine administration in patients with CH. Objective: The aim of the current study was to evaluate whether long-term levothyroxine replacement therapy in young adults with CH is associated with cardiovascular abnormalities. Patients and Methods: Thirty young adults with CH aged 18.1 ± 0.2 yr and 30 age- and sex-matched controls underwent cardiac and carotid Doppler ultrasound and symptom-limited cardiopulmonary exercise testing. Hypothyroidism was diagnosed by neonatal screening, and levothyroxine treatment was initiated within the first month of life and carefully adjusted to maintain TSH levels in the normal range and free T4 in the high-normal range. Results: Compared with controls, hypothyroid patients exhibited left ventricular diastolic dysfunction, impaired exercise capacity, and increased intima-media thickness. At multiple regression analysis, the number of episodes of plasma TSH levels less than 0.5 mU/liter and greater than 4.0 mU/liter from the age of 1 yr onward, and mean TSH plasma levels during puberty were independent predictors of diastolic filling and cardiopulmonary performance indexes (multiple r values: 0.61–0.75). Conclusions: Long-term levothyroxine treatment in young adults with congenital hypothyroidism is associated with impaired diastolic function and exercise capacity and increased intima-media thickness.

Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach

Thyroid ◽  
2018 ◽  
Vol 28 (12) ◽  
pp. 1580-1586 ◽  
Author(s):  
Sarantis Livadas ◽  
Christina Bothou ◽  
Ioannis Androulakis ◽  
Anastasios Boniakos ◽  
Nicholas Angelopoulos ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Diagnostic Approach ◽  
Levothyroxine Replacement

scholarly journals WD1 NHP AND 15D PERFORM WELL IN ASSESSMENT OF THE HRQOL OF HEALTHY WOMEN WITH HORMONE REPLACEMENT THERAPY

2002 ◽  
Vol 5 (6) ◽  
pp. 447
Author(s):  
H Sintonen ◽  
A Ohinmaa ◽  
S Johansson ◽  
P Kainulainen ◽  
M Apajasalo
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Healthy Women

Comparative Study of Chemerin and Inflammatory markers between Obese with Insulin Resistance and lean healthy women

2021 ◽  
pp. 3647-3650
Author(s):  
Moushira Zaki ◽  
Sanaa Kamal ◽  
Mona Abd Elmotaleb A. Hussein ◽  
Hend M. Tawfeek ◽  
Mina Wassef Girgiss ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Inflammatory Marker ◽  
Neutrophil To Lymphocyte Ratio ◽  
Metabolic Parameters ◽  
Low Grade ◽  
Obese Women ◽  
Fat Percentage ◽  
Inflammatory Biomarker ◽  
Lymphocyte Ratio ◽  
Healthy Women

Background: Chemerin has been newly defined to be released from mature adipocytes and the chemerin concentrations in human serum augmented with obesity. There is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. The aim of this study is to expound the prospective role of chemerin the in inflammation. Also, investigate relation between chemerin and serum lipid, glucose, body fat percentage, and metabolic parameters in obese and lean women with IR. Lymphocytes and neutrophils play a major role in inflammation and comprise the first line of defense against infection. The ratio of absolute neutrophil count to lymphocyte count, the neutrophil-to-lymphocyte ratio (NLR), determined as is a novel inflammatory biomarker utilized as a prognostic factor in numerous diseases Methods: This study was designed to investigate serum chemerin, NLR, and high-sensitive C-reactive protein (hsCRP) levels in 50 obese women with IR and 50 lean healthy women. Results: Obese group had significant higher levels of serum chemerin, NLR, hsCRP levels and metabolic parameters than lean one. Chemerin also correlated positively with NLR inflammatory marker and body mass index (BMI). Neutrophil‐to‐lymphocyte ratio was related to pro‐inflammatory Conclusion: The present study elucidates that chemerin levels are concomitant with obesity and IR and could play a role in the inflammation, having key aspects of metabolic syndrome.

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