Cinnamomum zeylanicum bark extract showed ameliorative properties against streptozotocin-induced insulin resistance in the hippocampus of experimental wistar rat

Branch bark extract (BBE) derived from the mulberry cultivar Husang 32 (Morus multicaulisL.) with aqueous alcohol solution has been investigated as an inhibitor ofα-glycosidasein vitro. Mulberry BBE was orally administered to STZ-induced diabetic mice for three weeks, and it improved the weight gain and ameliorated the swelling of liver and kidney in diabetic mice. Obviously, mulberry BBE not only can reduce the abnormally elevated levels of serum insulin and ameliorate insulin resistance induced by STZ, but also it regulates dyslipidemia in diabetic mice. To understand this therapeutic effect and the regulatory mechanisms of BBE in diabetic mice, a qRT-PCR experiment was performed, indicating that the mulberry BBE can regulate the mRNA expression of glycometabolism genes in diabetic mice, including glucose-6-phosphatase (G6Pase), glucokinase (GCK), and phosphoenolpyruvate carboxykinase (PEPCK), thereby regulating sugar metabolism and reducing the blood glucose level in diabetic mice. The mulberry BBE can increase the mRNA expression of the genes Ins1, Ins2 and pancreatic duodenal homeobox-1 (PDX-1) and may decrease the insulin resistance in diabetic mice. Those results provide an important basis for making the best use of mulberry branch resources and producing biomedical drugs with added value.

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Synthesis of Silver Nanoparticles using Cinnamomum zeylanicum Bark Extract and its Antioxidant Activity

Nanoscience &Nanotechnology-Asia ◽

10.2174/221068120501150728103209 ◽

2015 ◽

Vol 5 (1) ◽

pp. 2-7 ◽

Cited By ~ 9

Author(s):

Munnaluri Gauthami ◽

Nivedita Srinivasan ◽

Neelam M. Goud ◽

Kasilingam Boopalan ◽

Kavitha Thirumurugan

Keyword(s):

Antioxidant Activity ◽

Silver Nanoparticles ◽

Bark Extract ◽

Cinnamomum Zeylanicum

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Cinnamomum zeylanicum Blume (Ceylon cinnamon) bark extract attenuates doxorubicin induced cardiotoxicity in Wistar rats

Saudi Pharmaceutical Journal ◽

10.1016/j.jsps.2021.06.004 ◽

2021 ◽

Author(s):

Jayasinghe Arachchige Nirosha Sandamali ◽

Ruwani Punyakanthi Hewawasam ◽

Kamani Ayoma Perera Wijewardana Jayatilaka ◽

Lakmini Kumari Boralugoda Mudduwa

Keyword(s):

Wistar Rats ◽

Bark Extract ◽

Cinnamomum Zeylanicum ◽

Cinnamon Bark ◽

Ceylon Cinnamon

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Decreased leptin uptake in hypothalamic nuclei with ageing in Wistar rats

Journal of Endocrinology ◽

10.1677/joe.0.1710023 ◽

2001 ◽

Vol 171 (1) ◽

pp. 23-32 ◽

Cited By ~ 59

Author(s):

C Fernandez-Galaz ◽

T Fernandez-Agullo ◽

F Campoy ◽

C Arribas ◽

N Gallardo ◽

...

Keyword(s):

Insulin Resistance ◽

Leptin Receptor ◽

Wistar Rat ◽

Insulin Dependent Diabetes Mellitus ◽

Lower Amount ◽

Dependent Diabetes Mellitus ◽

Aged Rats ◽

Leptin Receptors ◽

Peripheral Insulin Resistance ◽

Hypothalamic Nuclei

Leptin interacts with specific receptors in hypothalamic nuclei and modulates energy balance. Growing evidence has shown the association of obesity and hyperleptinaemia with non-insulin-dependent diabetes mellitus and insulin resistance. The aged Wistar rat shows peripheral insulin resistance in the absence of obesity and alterations of glucose homeostasis. However, it is not known whether, in these animals, the leptin action is altered. Here we studied the effect of ageing on plasma leptin concentration and the ability of hypothalamic nuclei to capture i.c.v.-injected digoxigenin-labelled leptin. Our data indicate that 24-month-old animals are hyperleptinaemic. However, daily food intake was greater in old animals, suggesting that they are leptin resistant. Leptin uptake in the hypothalamus was reduced in old rats. This uptake was a receptor-mediated process as demonstrated by displacement. Leptin accumulation in hypothalamic nuclei was partially colocalized with neuropeptide Y fibres. Immunohistochemical and western blot analyses showed a lower amount of the long form of leptin receptors in the hypothalamus of aged rats. Analysis by RT-PCR also demonstrated a decreased expression of leptin receptor mRNA in old animals. We conclude that the lower leptin uptake may be explained, at least in part, by a decreased amount of receptors in hypothalamic neurones of the aged rats.

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