Effects of Aqueous Stem Bark Extract of Anogeissus leiocarpus on the Serum Levels of Progestin and Estradiol and the Estrous Cycle of Wistar Rat

2016 ◽  
Vol 2 (2) ◽  
Author(s):  
Murtala M. Jibril ◽  
Ojo S. Adeniyi ◽  
Zubairu S. Rayyanu
Keyword(s):  
Estrous Cycle ◽  
Wistar Rat ◽  
Serum Levels ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract ◽  
Anogeissus Leiocarpus

scholarly journals Assessment of the total aqueous stem bark extract of Sacoglottis gabonensis (Baille) Urban on the anatomo-histology of Wistar rat liver, kidneys and heart

2021 ◽  
Vol 9 (1) ◽  
pp. 35
Author(s):  
Kouassi Kousso Brigitte ◽  
Gnangoran Boua Narcisse ◽  
Kouadio Yao Emile ◽  
Koné Mama ◽  
Yapo Angoué Paul
Keyword(s):  
Rat Liver ◽  
Buruli Ulcer ◽  
Wistar Rat ◽  
Stem Bark ◽  
Bark Extract ◽  
Heart Cells ◽  
Cardiac Tissues ◽  
Stem Bark Extract ◽  
Histological Architecture ◽  
Gross Examination

Sacoglottis gabonensis is a medicinal plant used traditionally for the treatment of Buruli ulcer in Côte d’Ivoire. To ensure its effect over a long period of use, assessment of the total aqueous stem bark extract of S. gabonensis (ETASg) on anatomo-histology of Wistar rat liver, kidneys and heart was evaluated. ETASg was administered to Wistar rats at doses of 3.5; 35 and 350 mg/kg/day for 90 days. The liver of rats treated with ETASg at 35 and 350 mg/kg showed color and appearance changes with whitish nodules. Furthermore, histological architecture revealed micro-vesicular steatosis. In contrast, gross examination did not showed any change color and appearance of the kidneys and heart of the rats tested at all doses of ETASg compared to those of control rats. Histological sections of the kidneys and heart of rats tested at all doses of ETASg showed normal kidney and heart cells. After stopping the administration, the liver abnormalities disappeared at the end of the 120 days. This study revealed that the integrity of the liver tissue is preserved only with ETASg of 3.5 mg/kg. On the other hand, it is guaranteed at all the doses studied for the renal and cardiac tissues. 

scholarly journals Modulatory effect of Mangifera indica against carbon tetrachloride induced kidney damage in rats

2015 ◽  
Vol 8 (4) ◽  
pp. 175-183 ◽  
Author(s):  
Olufunsho Awodele ◽  
Adejuwon Adewale Adeneye ◽  
Sheriff Aboyade Aiyeola ◽  
Adokiye Senibo Benebo
Keyword(s):  
Kidney Diseases ◽  
Scientific Evidence ◽  
Mangifera Indica ◽  
Serum Levels ◽  
Stem Bark ◽  
Renal Tissue ◽  
Bark Extract ◽  
Before And After ◽  
Stem Bark Extract ◽  
Local Use

Abstract There is little scientific evidence on the local use of Mangifera indica in kidney diseases. This study investigated the reno-modulatory roles of the aqueous stem bark extract of Mangifera indica (MIASE) against CCl4-induced renal damage. Rats were treated intragastrically with 125, 250 and 500 mg/kg/day MIASE for 7 days before and after the administration of CCl4 (3 ml/kg of 30% CCl4, i.p.). Serum levels of electrolytes (Na+, K+, Cl−, HCO3−), urea and creatinine were determined. Renal tissue reduced glutathione (GSH), malondialdehyde (MDA), catalase (CAT), superoxide (SOD) activities were also assessed. The histopathological changes in kidneys were determined using standard methods. In CCl4 treated rats the results showed significant (p<0.05) increases in serum Na+, K+, Cl−, urea and creatinine. CCl4 also caused significant (p<0.05) decreases in renal tissue SOD, CAT and GSH and significant (p<0.05) increases in MDA. The oral MIASE treatment (125–500 mg/kg) was found to significantly (p<0.05) attenuate the increase in serum electrolytes, urea and creatinine. Similarly, MIASE significantly (p<0.05) attenuated the decrease in SOD, CAT and GSH levels and correspondingly attenuated increases in MAD. Mangifera indica may present a great prospect for drug development in the management of kidney disease with lipid peroxidation as its etiology.

scholarly journals Sub-chronic (28-days) Toxicity Study of Hydroalcohol Stem Bark Extract of Bridelia ferruginea (Euphorbiaceae) on Wistar Rat

2020 ◽  
Vol 20 (5) ◽  
pp. 191-195
Author(s):  
Kueviakoe Messanh Dél ◽  
Dossou-Yovo Komlan Maw ◽  
Diallo Aboudoulat ◽  
Vovor Ahoefa ◽  
Eklu-Gadegbeku Kwashie
Keyword(s):  
Wistar Rat ◽  
Stem Bark ◽  
Toxicity Study ◽  
Bark Extract ◽  
Bridelia Ferruginea ◽  
Stem Bark Extract

scholarly journals HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC STEM BARK EXTRACT OF KNEMA ATTENUATA (HOO K. F. AND THOMSON) WARB

2020 ◽  
pp. 78-82
Author(s):  
SUPRIYA RAJA H.
Keyword(s):  
Cell Line ◽  
Antioxidant Defense ◽  
Serum Levels ◽  
Stem Bark ◽  
Hepatoprotective Activity ◽  
Bark Extract ◽  
Control Group ◽  
Stem Bark Extract ◽  
Vitro Effect

Objective: To investigate the hepatoprotective activity of ethanolic stem bark extract (ESBE) of Knema attenuata against carbon tetrachloride (CCl4) induced hepatotoxicity in Wistar rats using both in vivo and in vitro models. Methods: Animals were treated orally with ESBE (250 mg kg-1 and 500 mg kg-1) once daily for 6 d and CCl4 on the 4th d. On the 7th d, animals were sacrificed and the blood samples were collected to measure the serum levels of biochemical parameters, whereas the liver homogenates were utilized for estimating the antioxidant defense. The hepatoprotective efficacy of the extract was further ensured in vitro using human liver hepatocellular carcinoma (HepG2) cell line against CCl4 induced toxicity. The cell line viability was determined using 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Results: ESBE effectively reduced (p<0.001) the elevated serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and Alkaline phosphatase (ALP) when compared to the toxicant control group. ESBE 500 mg kg-1significantly raised the antioxidant defense (p<0.0001) by reducing the malondialdehyde (MDA) level and enhancing hepatic reduced glutathione (GSH) level in comparison to the CCl4 control group. The in vitro effect was investigated using CCl4 exposed HepG2 cells. Pretreatment with ESBE showed a dose-dependent increase in percentage cell viability ranged between 44 to 57% at 12.5-100 μg ml-1concentrations (p<0.001, when compared to the control cells).  Conclusion: Present study confirms the hepatoprotective activity of the stem bark extract of K. attenuata against CCl4‑induced liver damage.

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