The Role of Interleukin-6 in a Patient with Polyclonal Hairy B-Cell Lymphoproliferative Disorder: A Case Report

2007 ◽  
Vol 13 (4) ◽  
pp. 124-127 ◽  
Author(s):  
Akio Okamoto ◽  
Tohru Inaba ◽  
Naohisa Fujita
Keyword(s):  
Case Report ◽  
B Cell ◽  
Interleukin 6 ◽  
Lymphoproliferative Disorder

scholarly journals Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation

2015 ◽  
Vol 90 (4) ◽  
pp. 2150-2154 ◽  
Author(s):  
Sang-Hoon Sin ◽  
Sun Ah Kang ◽  
Yongbaek Kim ◽  
Anthony Eason ◽  
Kelly Tan ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Interleukin 6 ◽  
Cell Activation ◽  
Marginal Zone ◽  
Kaposi Sarcoma ◽  
B Cell Activation ◽  
Marginal Zone B Cells ◽  
Survival Factor

Interleukin 6 (IL-6) is considered a proliferation and survival factor for B cells. To assess the role of IL-6 in Kaposi sarcoma-associated herpesvirus (KSHV) latency, KSHV latency locus-transgenic mice (referred to as latency mice) lacking IL-6 were evaluated. IL-6−/−latency mice had the same phenotypes as the latency mice, i.e., increased frequency of marginal zone B cells, hyperplasia, and hyperglobulinemia, indicating that the KSHV latency locus, which includes all viral microRNAs (miRNAs), can compensate for lack of IL-6 in premalignant B cell activation.

scholarly journals UNUSUAL PRESENTATION OF HAIRY CELL LEUKEMIA: A CASE REPORT

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Dr. Vartika Sachdeva ◽  
Dr. Mansi Kala ◽  
Dr. Sushil Kumar Shukla ◽  
Dr. Anuradha Kusum ◽  
Dr. Kunal Das
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
B Cell ◽  
Hairy Cell Leukemia ◽  
Lymphoproliferative Disorder ◽  
Case Reports ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Prominent Feature ◽  
High Level

Hairy cell leukemia is a chronic B cell lymphoproliferative disorder,which is uncommon and constitutes around  two percent of  hematolymphoid malignancies. HCL commonly involves bone marrow and spleen and  rarely peripheral blood . Splenomegaly is  a prominent feature and  is seen in around 70 to 100% of  HCL cases as reported  in various case reports. Sometimes the absence of splenomegaly rules out the diagnosis of HCL and   is misdiagnosed as aplastic anemia. Thus the aim of our study is to understand the importance and keep a high level of suspicion in such cases. As in present case there was no evidence of splenomegaly clinically or radiology, but the morphologic features on biopsy had suggested HCL which was further confirmed on immunophenotyping. The purpose of this case report is to highlight the importance of the fact that HCL can present even without splenomegaly. Keywords: Hairy cell leukemia, Splenomegaly, Immunohistochemistry

Renal Transplant Obstruction by B Cell Lymphoproliferative Disorder: Case Report and Review of the Literature

1988 ◽  
Vol 140 (3) ◽  
pp. 593-595 ◽  
Author(s):  
Lawrence J. Gibel ◽  
Antonia Harford ◽  
Louis R. Yogel ◽  
Jim Spiegel ◽  
William Sterling ◽  
...  
Keyword(s):  
Case Report ◽  
Renal Transplant ◽  
B Cell ◽  
Lymphoproliferative Disorder ◽  
Review Of The Literature

The role of human interleukin-6 in B-cell isotype regulation and differentiation

1990 ◽  
Vol 125 (1) ◽  
pp. 197-209 ◽  
Author(s):  
John N. Bertolini ◽  
Elizabeth M. Benson
Keyword(s):  
B Cell ◽  
Interleukin 6

Anemia in diffuse large B-cell non-Hodgkin lymphoma: the role of interleukin-6, hepcidin and erythropoietin

2013 ◽  
Vol 55 (2) ◽  
pp. 270-275 ◽  
Author(s):  
Maria Chiara Tisi ◽  
Valentina Bozzoli ◽  
Manuela Giachelia ◽  
Giuseppina Massini ◽  
Bianca Maria Ricerca ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Interleukin 6 ◽  
Non Hodgkin Lymphoma ◽  
Large B Cell
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