scholarly journals Translational Control of the Oogenic Program by Components of OMA Ribonucleoprotein Particles inCaenorhabditis elegans

Genetics ◽  
2014 ◽  
Vol 198 (4) ◽  
pp. 1513-1533 ◽  
Author(s):  
Caroline A. Spike ◽  
Donna Coetzee ◽  
Yuichi Nishi ◽  
Tugba Guven-Ozkan ◽  
Marieke Oldenbroek ◽  
...  
Keyword(s):  
Translational Control ◽  
Ribonucleoprotein Particles

scholarly journals Sequence-Independent Assembly of Spermatid mRNAs into Messenger Ribonucleoprotein Particles

1999 ◽  
Vol 19 (5) ◽  
pp. 3904-3915 ◽  
Author(s):  
Edward E. Schmidt ◽  
Eric S. Hanson ◽  
Mario R. Capecchi
Keyword(s):  
Translational Control ◽  
Transcriptional Activity ◽  
Sperm Maturation ◽  
Mrna Sequence ◽  
High Transcriptional Activity ◽  
Ribonucleoprotein Particles ◽  
Messenger Ribonucleoprotein ◽  
Specific Mrnas ◽  
Sequence Requirements

ABSTRACT During mammalian spermatogenesis, meiosis is followed by a brief period of high transcriptional activity. At this time a large amount of mRNA is stored as messenger ribonucleoprotein (mRNP) particles. All subsequent processes of sperm maturation occur in the complete absence of transcription, primarily using proteins which are newly synthesized from these stored mRNAs. By expressing transgene mRNAs in the early haploid spermatids of mice, we have investigated the sequence requirements for determining whether specific mRNAs in these cells will be stored as mRNP particles or be assembled into polysomes. The results suggest that mRNAs which are transcribed in spermatids are assembled into mRNP particles by a mechanism that acts independently of mRNA sequence. Our findings reveal a fundamental similarity between the mechanisms of translational control used in spermatogenesis and oogenesis.

The role of DUBs in the post-translational control of cell migration

2019 ◽  
Vol 63 (5) ◽  
pp. 579-594 ◽  
Author(s):  
Guillem Lambies ◽  
Antonio García de Herreros ◽  
Víctor M. Díaz
Keyword(s):  
Cell Migration ◽  
Translational Control ◽  
Epithelial To Mesenchymal Transition ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Mesenchymal Transition ◽  
Tgfβ Receptors ◽  
Fundamental Process ◽  
Multistep Process

Abstract Cell migration is a multifactorial/multistep process that requires the concerted action of growth and transcriptional factors, motor proteins, extracellular matrix remodeling and proteases. In this review, we focus on the role of transcription factors modulating Epithelial-to-Mesenchymal Transition (EMT-TFs), a fundamental process supporting both physiological and pathological cell migration. These EMT-TFs (Snail1/2, Twist1/2 and Zeb1/2) are labile proteins which should be stabilized to initiate EMT and provide full migratory and invasive properties. We present here a family of enzymes, the deubiquitinases (DUBs) which have a crucial role in counteracting polyubiquitination and proteasomal degradation of EMT-TFs after their induction by TGFβ, inflammatory cytokines and hypoxia. We also describe the DUBs promoting the stabilization of Smads, TGFβ receptors and other key proteins involved in transduction pathways controlling EMT.

RIBONUCLEOPROTEIN PARTICLES CONTAINING mRNA and pre-mRNA

1973 ◽  
Vol 74 (Suppl) ◽  
pp. S130-S167 ◽  
Author(s):  
O. P. Samarina ◽  
E. M. Lukanidin ◽  
G. P. Georgiev
Keyword(s):  
Structural Organization ◽  
General Scheme ◽  
Biological Significance ◽  
Mrna Transport ◽  
Ribonucleoprotein Particles ◽  
Mrna Precursor

ABSTRACT This paper is a review of the data concerning the nature, structural organization, properties and biological significance of the particles, containing mRNA and pre-mRNA (precursor of mRNA), i. e., (1) nuclear pre-mRNA-containing particles (2) free cytoplasmic mRNP (ribonucleoproteins), or informosomes (3) polysome-bound mRNP. Some new data on the comparison of nuclear and cytoplasmic particles, the nature of poly A-containing structures, involvement of informofers in Adenovirusspecific RNA transfer are presented. The general scheme of mRNA transport from nucleus to cytoplasm is discussed.

Translational Control during Early Development

1997 ◽  
Vol 7 (1-2) ◽  
pp. 73-94 ◽  
Author(s):  
Barbara Stebbins-Boaz ◽  
Joel D. Richter
Keyword(s):  
Early Development ◽  
Translational Control
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