Abstract
Purpose We determined the minimum required breath-holding time (Modified 1H-MRS) and conducted a backward study on patients who underwent intrahepatic fat quantification using the point resolved spectroscopy method. We investigated the correlation between dual echo-MRI (DE-MRI) and liver attenuation index (LAI) measurements and evaluated the validity of the analysis results to determine whether breath-holding time (BHT) could be reduced.Methods In the MRS-fat fraction (MRS-FF) analysis, using only the reference datasets, the minimum required breath-holding time was set to 14 s. To evaluate the validity of the obtained MRS-FF, we compared the correlation using the dual echo-fat fraction (DE-FF) and LAI as a reference values, the correlation coefficient was investigated by obtaining the Spearman’s rank correlation coefficient. Next, we compared the correlation in two subgroups of the abovementioned case groups: (1) those with a BHT of 23 s and (2) those with a BHT between 14 to 22 s.Results The correlation coefficients between MRS-FF and DE-FF and MRS-FF and LAI were 0.841 (p = 0.00) and − 0.726 (p < 0.01), respectively. Next, in the subgroup analysis, the correlation coefficients of MRS-FF and DE-FF and MRS-FF and LAI were 0.849 (p = 0.00) and − 0.733 (p = 0.00), respectively, in group (1) and 0.886 (p = 0.00) and − 0.761 (p = 0.00), respectively, in group (2).Conclusion In the imaging using Modified 1H-MRS, the present method suggested that the reduction in breath-holding time from 14 to 22 s did not affect the MRS-FF analysis results.
Relative contributions of chemical and non-chemical drives to the breath-holding time in breath-hold divers (ama).
