scholarly journals Protective effects of taxifolin on pazopanib-induced liver toxicity: an experimental rat model

2020 ◽  
Author(s):  
Baran AKAGUNDUZ ◽  
Muhammet OZER ◽  
Fatih OZCICEK ◽  
Ali Veysel KARA ◽  
Sahin LACIN ◽  
...  
Keyword(s):  
Rat Model ◽  
Liver Toxicity ◽  
Protective Effects ◽  
Experimental Rat Model

Protective Effects of Astragaloside IV on Delayed Cerebral Vasospasm in an Experimental Rat Model of Subarachnoid Hemorrhage

2018 ◽  
Vol 118 ◽  
pp. e443-e448 ◽  
Author(s):  
Yudong Ma ◽  
Guangyu Qiao ◽  
Yiheng Yin ◽  
Yan Zhang ◽  
Yaoyu Yu ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Vasospasm ◽  
Rat Model ◽  
Protective Effects ◽  
Astragaloside Iv ◽  
Delayed Cerebral Vasospasm ◽  
Experimental Rat Model

Protective Effects of Bilirubin in an Experimental Rat Model of Pyelonephritis

Urology ◽  
2012 ◽  
Vol 80 (6) ◽  
pp. 1389.e17-1389.e22 ◽  
Author(s):  
Belde Kasap ◽  
Alper Soylu ◽  
Dilek Ertoy Baydar ◽  
Müge Kiray ◽  
Kazım Tuğyan ◽  
...  
Keyword(s):  
Rat Model ◽  
Protective Effects ◽  
Experimental Rat Model

The Protective Effects of Acetylsalicylic Acid on Free Radical Production in Cisplatin Induced Nephrotoxicity: An Experimental Rat Model

2003 ◽  
Vol 26 (4) ◽  
pp. 259-270 ◽  
Author(s):  
Bahar Ulubaş ◽  
M. Y. Burak Çımen ◽  
Duygu Düşmez Apa ◽  
Emel Saritaş ◽  
Necatı Muşlu ◽  
...  
Keyword(s):  
Free Radical ◽  
Acetylsalicylic Acid ◽  
Rat Model ◽  
Protective Effects ◽  
Free Radical Production ◽  
Radical Production ◽  
Experimental Rat Model

scholarly journals Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis

2018 ◽  
Vol 46 (7) ◽  
pp. 2828-2842 ◽  
Author(s):  
Nurdan Bedirli ◽  
Emin Umit Bagriacik ◽  
Guldal Yilmaz ◽  
Zerrin Ozkose ◽  
Mustafa Kavutçu ◽  
...  
Keyword(s):  
Rat Model ◽  
Memory Impairment ◽  
Caspase 3 ◽  
Cecal Ligation ◽  
Weight Ratio ◽  
Dry Weight ◽  
Protective Effects ◽  
Tissue Samples ◽  
Isoflurane Group ◽  
Experimental Rat Model

Objective We compared the effects of sevoflurane and isoflurane on systemic inflammation, sepsis-associated encephalopathy, and memory impairment in a rat sepsis model of cecal ligation and puncture (CLP)-induced polymicrobial peritonitis. Methods Twenty-four rats were assigned to sham, CLP, CLP + sevoflurane, and CLP + isoflurane groups. At 72 hours after CLP, the rats underwent behavior tests. Serum cytokines were evaluated. Brain tissue samples were collected for determination of glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase; the wet/dry weight ratio; myeloperoxidase (MPO) and malondialdehyde (MDA); apoptotic gene release; and histologic examinations. Results The MPO level, wet/dry weight ratio, and histopathology scores were lower and the Bcl2a1 and Bcl2l2 expressions were upregulated in both the CLP + sevoflurane and CLP + isoflurane groups compared with the CLP group. The interleukin-6, interleukin-1β, MDA, and caspase 3, 8, and 9 levels were lower; the GPX, SOD, Bax, Bcl2, and Bclx levels were higher; and non-associative and aversive memory were improved in the CLP + sevoflurane group compared with the CLP + isoflurane group. Conclusion Sevoflurane decreased apoptosis and oxidative injury and improved memory in this experimental rat model of CLP. Sevoflurane sedation may protect against brain injury and memory impairment in septic patients.

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