scholarly journals Comparison of the wound-healing efficacy of gelatin sponge dressings and that of artificial dermis using atelocollagen in a rat cranial periosteal defect model

2021 ◽  
Author(s):  
Yasuyuki ASADA ◽  
Shinya KOSHINUMA ◽  
Masaki MIKAMI ◽  
Yuuki SHIRAI ◽  
Yoshisato MACHIDA ◽  
...  
Keyword(s):  
Wound Healing ◽  
Gelatin Sponge ◽  
Defect Model ◽  
Artificial Dermis

scholarly journals Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xinchen Du ◽  
Le Wu ◽  
Hongyu Yan ◽  
Zhuyan Jiang ◽  
Shilin Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Shape Recovery ◽  
Parenchymal Cell ◽  
Gelatin Sponge ◽  
Defect Model ◽  
Liver Parenchymal Cell ◽  
E Coli ◽  
Tissue Integration ◽  
3D Printed

AbstractDeveloping an anti-infective shape-memory hemostatic sponge able to guide in situ tissue regeneration for noncompressible hemorrhages in civilian and battlefield settings remains a challenge. Here we engineer hemostatic chitosan sponges with highly interconnective microchannels by combining 3D printed microfiber leaching, freeze-drying, and superficial active modification. We demonstrate that the microchannelled alkylated chitosan sponge (MACS) exhibits the capacity for water and blood absorption, as well as rapid shape recovery. We show that compared to clinically used gauze, gelatin sponge, CELOX™, and CELOX™-gauze, the MACS provides higher pro-coagulant and hemostatic capacities in lethally normal and heparinized rat and pig liver perforation wound models. We demonstrate its anti-infective activity against S. aureus and E. coli and its promotion of liver parenchymal cell infiltration, vascularization, and tissue integration in a rat liver defect model. Overall, the MACS demonstrates promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing.

scholarly journals Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

2016 ◽  
Vol 65 (4) ◽  
pp. 473-483 ◽  
Author(s):  
Shinya Koshinuma ◽  
Shoko Murakami ◽  
Masaharu Noi ◽  
Takuya Murakami ◽  
Ken-Ichi Mukaisho ◽  
...  
Keyword(s):  
Wound Healing ◽  
Fibrin Glue ◽  
Polyglycolic Acid ◽  
Gelatin Sponge ◽  
Defect Model

Events of wound healing/regeneration in the canine supraalveolar periodontal defect model

2013 ◽  
Vol 40 (5) ◽  
pp. 527-541 ◽  
Author(s):  
Douglas P. Dickinson ◽  
Brandon G. Coleman ◽  
Nathan Batrice ◽  
Jaebum Lee ◽  
Komal Koli ◽  
...  
Keyword(s):  
Wound Healing ◽  
Defect Model

scholarly journals Cografts of artificial dermis matrix and autogenetic split-thickness of repaired skin in severe hand wounds in patients with deep burns

2014 ◽  
Vol 66 (1) ◽  
pp. 173-178
Author(s):  
Hongqi Liu ◽  
Yan Li ◽  
Deqian Sha
Keyword(s):  
Wound Healing ◽  
Hand Function ◽  
Donor Site ◽  
Test Group ◽  
Healing Time ◽  
Whole Body ◽  
Control Group ◽  
Large Area ◽  
Artificial Dermis ◽  
Thickness Skin

The aim of this paper was to evaluate the effect of using artificial dermis matrix plus autologous split-thickness skin (ADM and ASTS) in the treatment of deep-burns in hands of severely burned patients?We recruited a total of 58 patients with large area burns greater than 80% that were eschar-excised. Twenty-eight of them were treated with ADM and ASTS (test group); 30 were treated with autologous medium-thickness skin (AMTS) (control group). The healing time of the hand wound was noted, clinical and photographic evaluations were performed, and a Jebsen-Taylor hand function test was compared and analyzed in the two groups. The wound healing time in the test group (24.22?3.34 days) were longer than that of the control group (13.42?3.36 days) and statistically significant. The healing time of skin graft donor sites was shorter than that of the control group (7.14?1.63 vs. 14.28?2.37 days) and statistically significant (P<0.05). The 3rd and 6th month follow-up with clinical and functional evaluations revealed no differences between the two groups. In addition, there was no obvious scar formation and less pigmentation in either group. The repair of deeply burned hands with artificial dermis matrix was beneficial to both wound healing and the donor site, and was beneficial to the whole body rehabilitation of severely burned patients.

P-II-03 Effect of Platelet Derived Wound Healing Factor (PDWHF) on the Angiogenesis in the Cases of Artificial Dermis Grafts

2004 ◽  
Vol 12 (1) ◽  
pp. A6-A6
Author(s):  
Soejima Kazutaka ◽  
Xin Chen ◽  
Yamato Masayuki ◽  
Okano Teruo ◽  
Nozaki Motohiro
Keyword(s):  
Wound Healing ◽  
Artificial Dermis

P-II-03 
Effect of Platelet Derived Wound Healing Factor (PDWHF) on the Angiogenesis in the Cases of Artificial Dermis Grafts

2004 ◽  
Vol 12 (1) ◽  
pp. A6-A6
Author(s):  
Soejima Kazutaka ◽  
Xin Chen ◽  
Yamato Masayuki ◽  
Okano Teruo ◽  
Nozaki Motohiro
Keyword(s):  
Wound Healing ◽  
Artificial Dermis

Evaluation of an artificial dermis full-thickness skin defect model in the rat

Biomaterials ◽  
1996 ◽  
Vol 17 (10) ◽  
pp. 989-994 ◽  
Author(s):  
Risako Matsui ◽  
Ken-ichi Osaki ◽  
Jun Konishi ◽  
Kazuhito Ikegami ◽  
Mikio Koide
Keyword(s):  
Skin Defect ◽  
Full Thickness ◽  
Defect Model ◽  
Full Thickness Skin ◽  
Artificial Dermis ◽  
Thickness Skin

scholarly journals A novel microcurrent dressing for wound healing in a rat skin defect model

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Chao Yu ◽  
Zhi-Xiu Xu ◽  
Yan-Hui Hao ◽  
Ya-Bing Gao ◽  
Bin-Wei Yao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Defect ◽  
Rat Skin ◽  
Defect Model ◽  
Microcurrent Dressing

scholarly journals A Novel Multilayer Composite Membrane for Wound Healing in Mice Skin Defect Model

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 573 ◽  
Author(s):  
Yuyu Qiu ◽  
Qingqing Wang ◽  
Yajun Chen ◽  
Shufang Xia ◽  
Wei Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Animal Experiments ◽  
Skin Wound ◽  
Control Group ◽  
Skin Defect ◽  
Multilayer Composite ◽  
Defect Model ◽  
Skin Wound Healing

To develop a wound dressing material that conforms to the healing process, we prepared a multilayer composite (MC) membrane consisting of an antibacterial layer (ABL), a reinforcement layer (RFL), and a healing promotion layer (HPL). Biocompatible zein/ethyl cellulose (zein/EC) electrospun nanofibrous membranes with in situ loaded antibacterial photosensitizer protoporphyrin (PPIX) and healing promotion material vaccarin (Vac) were, respectively, chosen as the ABL on the surface and the HPL on the bottom, between which nonwoven incorporated bacterial cellulose (BC/PETN) as the HPL was intercalated to enhance the mechanical property. Photodynamic antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was confirmed by the enlarged inhibition zones; meanwhile, satisfactory biocompatibility of the HPL was verified by scanning electronic microscopy (SEM) of L929 cells cultured on its surface. The potential effects on wound healing in a mice skin defect model of the MC membranes were also evaluated. The animal experiments demonstrated that the wound healing rate in the MC group was significantly increased compared with that in the control group (p < 0.05). Histopathological observation revealed an alleviated inflammatory response, accompanied with vascular proliferation in the MC group. The MC membranes significantly promoted wound healing by creating an antibacterial environment and promoting angiogenesis. Taken together, this MC membrane may act as a promising wound dressing for skin wound healing.

scholarly journals Effect of A-PRF Application on Palatal Wound Healing after Free Gingival Graft Harvesting: A Prospective Randomized Study

2020 ◽  
Vol 14 (01) ◽  
pp. 063-069 ◽  
Author(s):  
Filipa Sousa ◽  
Vanessa Machado ◽  
João Botelho ◽  
Luís Proença ◽  
José João Mendes ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Recovery Period ◽  
Gelatin Sponge ◽  
Control Group ◽  
Total Recovery ◽  
Pain Experience ◽  
Free Gingival Graft ◽  
Significant Difference ◽  
Gingival Graft

Abstract Objective The aim of this study was to investigate the healing effect of advanced platelet-rich fibrin (A-PRF) clot membranes in palatal wounds, resulting from free gingival graft (FGG) harvesting, on the reepithelization rate and on the pain experience after surgery. Materials and Methods Twenty-five patients requiring FGG have participated in this prospective cohort study. After FGG harvesting, the test group (n = 14) received A-PRF clot membranes at the palatal wound and the control group (n = 11) received a gelatin sponge. Epithelialization rate of the palatal wound, wound healing area, correspondent percentage of reduction, and postsurgical pain experience were assessed at 2, 7, 14, 30, and 90 days. Results A-PRF group had higher palatal wound reduction than the control group, at 7, 14, and 30 days of follow-up. The highest difference between the groups was attained at 30 days (91.5% for A-PRF vs. 59.0% control group). At 14 days, a significant difference in the proportion of patients showing total epithelization was found: 64.3% for A-PRF versus 9.1% for the control group. At 90 days, both groups showed total recovery. The control group experienced higher pain level and discomfort until the 14th day, being notably higher on the second day. Conclusion The results suggest that A-PRF membranes haste the healing process, and promote greater reduction along the recovery period and less painful postoperative period.

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