scholarly journals Bilateral absence of vas deferens (BAVD) a case report

2021 ◽  
Vol 11 (3) ◽  
pp. 64-66
Author(s):  
Mzyiene Mohammed
Keyword(s):  
Cystic Fibrosis ◽  
In Vitro Fertilization ◽  
Human Reproduction ◽  
Obstructive Azoospermia ◽  
Vitro Fertilization ◽  
Primary Infertility ◽  
Bilateral Absence ◽  
Reproductive Techniques ◽  
Almost All

Mutations in transmembrane conductance of cystic fibrosis (CFTR) are found in men in couples followed for infertility and for which azoospermia associated with congenital bilateral absence of the deferential canal (CBAVD) were found in men. There is a frequent association between CFTR and CBAVD abnormalities. CBAVD exists in almost all men with cystic fibrosis and causes an obstructive azoospermia that cannot be treated surgically; this poses a diagnostic and therapeutic problem because its management remains complex. However, with the use of assisted reproductive techniques (ART), in particular the aspiration of testicular or epididymic sperm, the injection of intracytoplasmic sperm and in vitro fertilization, it is possible that men with CBAVD can produce offspring. We report the case of a 32-year-old patient who consulted for primary infertility evolving over the past 5 years (genetic advice was provided). The aim of this article is to show the diagnostic and therapeutic difficulties related to this particular form of male primary infertility. Recent assisted human reproduction techniques like Intracytoplasmic Sperm Injection (ICSI) or In Vitro Fertilization (FIV) offer very good results for couple consulting for infertility of man with CBAVD.

scholarly journals The obligate need for accuracy in reporting preclinical studies relevant to clinical trials: autologous germline mitochondrial supplementation for assisted human reproduction as a case study

2020 ◽  
Vol 14 ◽  
pp. 263349412091735
Author(s):  
Jonathan L. Tilly ◽  
Dori C. Woods
Keyword(s):  
Energy Transfer ◽  
In Vitro Fertilization ◽  
Clinical Studies ◽  
Human Reproduction ◽  
Fertility Treatment ◽  
Success Rates ◽  
Vitro Fertilization ◽  
Mouse Study ◽  
Mitochondrial Supplementation

A now large body of work has solidified the central role that mitochondria play in oocyte development, fertilization, and embryogenesis. From these studies, a new technology termed autologous germline mitochondrial energy transfer was developed for improving pregnancy success rates in assisted reproduction. Unlike prior clinical studies that relied on the use of donor, or nonautologous, mitochondria for microinjection into eggs of women with a history of repeated in vitro fertilization failure to enhance pregnancy success, autologous germline mitochondrial energy transfer uses autologous mitochondria collected from oogonial stem cells of the same woman undergoing the fertility treatment. Initial trials of autologous germline mitochondrial energy transfer during - in vitro fertilization at three different sites with a total of 104 patients indicated a benefit of the procedure for improving pregnancy success rates, with the birth of children conceived through the inclusion of autologous germline mitochondrial energy transfer during in vitro fertilization. However, a fourth clinical study, consisting of 57 patients, failed to show a benefit of autologous germline mitochondrial energy transfer– in vitro fertilization versus in vitro fertilization alone for improving cumulative live birth rates. Complicating this area of work further, a recent mouse study, which claimed to test the long-term safety of autologous mitochondrial supplementation during in vitro fertilization, raised concerns over the use of the procedure for reproduction. However, autologous mitochondria were not actually used for preclinical testing in this mouse study. The unwarranted fears that this new study’s erroneous conclusions could cause in women who have become pregnant through the use of autologous germline mitochondrial energy transfer during- in vitro fertilization highlight the critical need for accurate reporting of preclinical work that has immediate bearing on human clinical studies.

Editorial-SURROGACY

2016 ◽  
Vol 32 (2) ◽  
Author(s):  
O.S. Verma
Keyword(s):  
In Vitro Fertilization ◽  
Intrauterine Insemination ◽  
Natural Course ◽  
Assisted Reproductive Techniques ◽  
Egg Donation ◽  
Surrogate Mother ◽  
Vitro Fertilization ◽  
Reproductive Techniques

Worldwide, about 200 million couples are infertile. Almost 15 per cent of them require ART and IVF treatments. Couples who are unable to conceive even after years of trying could use procedure called Assisted Reproductive Techniques (ART) to get pregnant. These includes Intrauterine Insemination, In-Vitro Fertilization (IVF), Spern / Egg donation, and Gestational Carriers called “Surrogacy”. People join for Surrogacy when they want to have their genes in the child but can not make it happen in natural course. There are two types of Surrogacy: (1) The man’s sperm and the woman’s ova is injected in the uterus of the surrogate mother who rents out her womb for the child, (2) If the Egg of the mother is not good enough to produce a baby, an Egg is then rented out by donor mother. A tripartite agreement is duly signed according to the terms and conditions prevalent at that time. This Editorial viewed Surrogacy Industry through the lens of intent, efficacy, and its purview.

Sign in / Sign up

Export Citation Format

Share Document