Up-Regulation of microrna-125b Induced By 5-Fluorouracil (5-FU) Treatment Inhibits Cell Growth and Proliferation in Pancreatic Cancer Cells

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Yehai Liu
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
Cell Growth And Proliferation

scholarly journals Demethylzeylasteral (ZST93) inhibits cell growth and enhances cell chemosensitivity to gemcitabine in human pancreatic cancer cells via apoptotic and autophagic pathways

2018 ◽  
Vol 142 (9) ◽  
pp. 1938-1951 ◽  
Author(s):  
Feng Wang ◽  
Xiaodong Tian ◽  
Zhengkui Zhang ◽  
Yongsu Ma ◽  
Xuehai Xie ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells

PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways

2015 ◽  
Vol 76 (1) ◽  
pp. 96-107 ◽  
Author(s):  
Brajesh P. Kaistha ◽  
Holger Lorenz ◽  
Harald Schmidt ◽  
Bence Sipos ◽  
Michael Pawlak ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Pancreatic Cancer ◽  
Plasma Membrane ◽  
Cell Growth ◽  
Cancer Cells ◽  
Disease Progression ◽  
Regulatory Pathways ◽  
Pancreatic Cancer Cells

scholarly journals hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223

2020 ◽  
Vol 319 (6) ◽  
pp. G703-G717 ◽  
Author(s):  
Xiutian Zhang ◽  
Peng Tan ◽  
Yuan Zhuang ◽  
Lei Du
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Solute Carrier Family ◽  
Potential Target ◽  
Pancreatic Cancer Cells ◽  
Solute Carrier

Human circular (hsa_circ)RNA_001587 and solute carrier family 4 member 4 (SLC4A4) are poorly expressed, but microRNA (miR)-223 is overexpressed in pancreatic cancer (PC) cells. hsa_circRNA_001587 binds to miR-223. Overexpression of hsa_circRNA_001587 inhibits PC progression. Overexpression of miR-223 downregulates the expression of SLC4A4 and promotes PC cell growth. hsa_circRNA_001587 may be a potential target for PC treatment.

Cold Physical Plasma-Treated Buffered Saline Solution as Effective Agent Against Pancreatic Cancer Cells

2018 ◽  
Vol 18 (6) ◽  
pp. 824-831 ◽  
Author(s):  
Sander Bekeschus ◽  
André Käding ◽  
Tim Schröder ◽  
Kristian Wende ◽  
Christine Hackbarth ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Clinical Relevance ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells ◽  
Anticancer Effects ◽  
Murine Fibroblasts ◽  
Physical Plasma

Background: Cold physical plasma has been suggested as a new anticancer tool recently. However, direct use of plasma is limited to visible tumors and in some clinical situations, is not feasible. This includes repetitive treatment of peritoneal metastases, which commonly occur in advanced gastrointestinal cancer and in pancreatic cancer in particular. In case of diffuse intraperitoneal metastatic spread, Hyperthermic Intraperitoneal Intraoperative Chemotherapy (HIPEC) is used as a therapeutic approach. Plasma-treated solutions may combine non-toxic characteristics with the anticancer effects of HIPEC. Previous work has provided evidence for an anticancer efficacy of plasma-treated cell culture medium but the clinical relevance of such an approach is low due to its complex formulation and lack of medical accreditation. Objective: Plasma-treated Phosphate-Buffered Saline (PBS), which closely resembles medically certified solutions, was investigated for its cytotoxic effect on 2D monolayer murine pancreatic cancer cells in vitro. Methods: Toxicity studies of primary murine fibroblasts, PDA6606 murine pancreatic cancer cells, and COLO 357 human pancreatic cancer cells exposed to plasma-treated PBS were performed. Results: Plasma-treated PBS significantly decreased cancer cell metabolisms and proliferation whereas plasma-treated Dulbecco’s Modified Eagle Medium had no effect. Moreover, tumor cell growth attenuation was significantly higher when compared to syngeneic primary murine fibroblasts. Both results were confirmed in a human pancreatic cancer cell line. Finally, plasma-treated PBS also decreased the size of pancreatic tumors in a three-dimensional manner, and induction of apoptosis was found to be responsible for all anticancer effects identified. Conclusion: Plasma-treated PBS inhibited cell growth in 2D and 3D models of cancer. These results may help facilitate the development of new plasma-derived anticancer agent with clinical relevance in the future.

scholarly journals Involvement of MEK–ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells

2005 ◽  
Vol 332 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Wataru Motomura ◽  
Satoshi Tanno ◽  
Nobuhiko Takahashi ◽  
Miho Nagamine ◽  
Mitsuko Fukuda ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Erk Signaling ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells

Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells

2014 ◽  
Vol 231 (1) ◽  
pp. 82-91 ◽  
Author(s):  
Jia Ma ◽  
Binbin Fang ◽  
Fanpeng Zeng ◽  
Haijie Pang ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells

Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells

Cancer ◽  
2000 ◽  
Vol 89 (7) ◽  
pp. 1440-1447 ◽  
Author(s):  
Thomas Schnelldorfer ◽  
Susanne Gansauge ◽  
Frank Gansauge ◽  
Sophia Schlosser ◽  
Hans G. Beger ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Glutathione Depletion ◽  
Cell Growth Inhibition ◽  
Pancreatic Cancer Cells
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