Composite materials based on isocyanurate-containing polyurethane with a prolonged release of doxorubicin

2019 ◽  
Vol 41 (4) ◽  
pp. 271-278
Author(s):  
S.A. Lukashevich ◽  
◽  
R.A. Rozhnova ◽  
G.A. Kozlova ◽  
L.Yu. Nechaeva ◽  
...  
Morphologia ◽  
2021 ◽  
Vol 15 (2) ◽  
pp. 16-24
Author(s):  
N.A. Galatenko ◽  
D.V. Kuliesh ◽  
V.P. Gritsenko ◽  
L.F. Narazhayko

Background. The development of biocompatible polymeric implant materials and providing them with biological activity is an urgent task that can significantly increase the effectiveness of such materials when used in medical practice. Objective. Investigation of the interaction of connective tissue culture matrix cells with a prolonged form of the proteolytic enzyme lysozyme as part of a polyurethane implant in vitro and study of the effect of this form on cells and tissues during implantation in experimental animals in vivo. Methods. In order to study the possible cytotoxicity of the components of polymer composite materials and the effect of lysozyme on the growth and development of the culture of fibroblastic elements, studies were performed by tissue culture in vitro. Polymeric composite materials based on polyurethaneurea without and with lysozyme were implanted into the body of white laboratory rats of the Wistar line. Cellular responses of the body after implantation were studied by light microscopy by analysis of histological micropreparations. Results. Biological studies have assessed the effect of prolonged lysozyme on cells and tissues in vitro and in vivo. Conclusion. The fibroblast tissue culture method showed the effectiveness of biologically active polyurethaneureas with prolonged release of lysozyme, which was expressed in the prolongation of the dynamics of growth and development of cellular elements in vitro. It has been shown that lysozyme in the composition of polymer composite materials had a biological effect and helped to reduce the cellular response to the implantation of polymer samples, accelerating the formation of connective tissue capsules around the implants.


Author(s):  
R.R. Russell

Transmission electron microscopy of metallic/intermetallic composite materials is most challenging since the microscopist typically has great difficulty preparing specimens with uniform electron thin areas in adjacent phases. The application of ion milling for thinning foils from such materials has been quite effective. Although composite specimens prepared by ion milling have yielded much microstructural information, this technique has some inherent drawbacks such as the possible generation of ion damage near sample surfaces.


Author(s):  
K.P.D. Lagerlof

Although most materials contain more than one phase, and thus are multiphase materials, the definition of composite materials is commonly used to describe those materials containing more than one phase deliberately added to obtain certain desired physical properties. Composite materials are often classified according to their application, i.e. structural composites and electronic composites, but may also be classified according to the type of compounds making up the composite, i.e. metal/ceramic, ceramic/ceramie and metal/semiconductor composites. For structural composites it is also common to refer to the type of structural reinforcement; whisker-reinforced, fiber-reinforced, or particulate reinforced composites [1-4].For all types of composite materials, it is of fundamental importance to understand the relationship between the microstructure and the observed physical properties, and it is therefore vital to properly characterize the microstructure. The interfaces separating the different phases comprising the composite are of particular interest to understand. In structural composites the interface is often the weakest part, where fracture will nucleate, and in electronic composites structural defects at or near the interface will affect the critical electronic properties.


2016 ◽  
Vol 2 (2) ◽  
pp. 37-42 ◽  
Author(s):  
E. N. Kablov ◽  
L. V. Chursova ◽  
A. N. Babin ◽  
R. R. Mukhametov ◽  
N. N. Panina

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