scholarly journals Peculiarities of arginase and NO-synthase pathways of L-arginine metabolism in peripheral blood lymphocytes of patients with ovarian cancer

2013 ◽  
Vol 85 (6) ◽  
pp. 105-113 ◽  
Author(s):  
O. I. Yakubets ◽  
◽  
R. V. Fafula ◽  
D. Z. Vorobets ◽  
Z. D. Vorobets ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
No Synthase ◽  
Arginine Metabolism ◽  
Blood Lymphocytes

A Preliminary Study on the Functional Analysis of Peripheral Blood Lymphocytes from Ovarian Cancer Patients Developing Hama after Immunoscintigraphy

1994 ◽  
Vol 9 (2) ◽  
pp. 115-120 ◽  
Author(s):  
B. Donnerstag ◽  
R.P. Baum ◽  
J.B. Oltrogge ◽  
A. Hertel ◽  
G. Hör
Keyword(s):  
Ovarian Cancer ◽  
Functional Analysis ◽  
Cytotoxic Activity ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Ca 125 ◽  
Blood Lymphocytes ◽  
Tumor Associated Antigen

In the follow-up of ovarian cancer patients, rising levels of the tumor-associated antigen CA 125 are an indication for immunoscintigraphy. Human anti-mouse antibodies (HAMA) are frequently found after immunoscintigraphy with murine MAb directed against CA 125. Since we observed that patients developing high HAMA-levels in serum remained free of tumor or had stable disease, we examined the cytotoxic activity of peripheral blood lymphocytes (PBL) by a fluorescence-based assay. Our results demonstrate that PBLs of patients with high anti-idiotypic antibodies show an increased cytotoxic activity (by a factor of 4) compared to those of patients with low HAMA levels. The clinical course of the patients after the first injection of murine monoclonal antibody was observed over a period of 1 to 3 years. Improvement or deterioration of patients ‘ clinical condition corresponded with the results obtained by functional analysis. Further investigations concerning the course of cytotoxic activity in HAMA-positive patients will have to clarify HAMA's role in the immune response.

scholarly journals Cytokine production by peripheral blood lymphocytes in patients with ovarian epithelial tumors

2021 ◽  
Vol 50 (1) ◽  
pp. 37-40
Author(s):  
R. V. Pavlov ◽  
V. A. Aksenenko ◽  
A. Yu. Krivoruchko ◽  
N. A. Pavlenko
Keyword(s):  
Ovarian Cancer ◽  
Peripheral Blood ◽  
Cytokine Production ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes ◽  
Epithelial Tumors ◽  
Ovarian Epithelial Tumors ◽  
Type Activity ◽  
T Helpers ◽  
Dependent Mechanism

In presence of autoserum, production of IL1b, IL2, IL4, IL6 and TNFa by peripheral blood lymphocytes of 30 patients with epithelial tumors of ovaries and 50 patients with epithelial ovarian cancer of I-IV stages was investigated. The data received enable to ascertain the increase of mononuclear activity during ovarian tumor progression, increase of T-helpers of the second type activity, along with the reduction of T-helpers of the first type activity in peripheral blood of patients, and abnormalities of IL6-dependent mechanism of control of ILIb and TNFa production by peripheral blood lymphocytes of patients with ovarian cancer.

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