Congenital Malformations of the Heart

PEDIATRICS ◽  
1948 ◽  
Vol 1 (2) ◽  
pp. 298-298
Author(s):  
JAMES GOODFRIEND
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Clinical Knowledge ◽  
Cardiac Anomalies ◽  
Congenital Cardiac Anomalies ◽  
Circulatory Dynamics

Seldom has a monograph or text been so eagerly awaited as Dr. Taussig's summation of her observations of congenital malformations of the heart, and rarely has a book so completely justified the pre-publication interest it evoked as does this. Dr. Taussig's investigations of congenital cardiac anomalies have for some years been directed toward increasing clinical knowledge of these conditions and have been related to Dr. Maude Abbott's classical pathologic studies. All the clinical types of congenital heart disease are here discussed in detail. The embryologic aberration is pointed out. With the nature of the anatomic deformity established, the inevitable alterations in circulatory dynamics are then considered and the conclusions in each instance are presented in diagrammatic form.

Trazodone-Associated Syncope in a Patient with Congenital Cardiac Anomalies

1998 ◽  
Vol 14 (2) ◽  
pp. 78-81
Author(s):  
Vinod S Bhatara ◽  
Sami Awadallah
Keyword(s):  
Risk Factors ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Noonan Syndrome ◽  
Congenital Heart ◽  
Cardiac Defects ◽  
Congenital Cardiac Defects ◽  
Cardiac Anomalies ◽  
Case Summary ◽  
Congenital Cardiac Anomalies

Objective: To report a case of trazodone-associated syncope in a 19-year-old woman with congenital cardiac anomalies and to review risk factors and mechanisms involved in this case. Case Summary: A 19-year-old woman diagnosed with Noonan syndrome with congenital cardiac anomalies tolerated sertraline, but had a syncopal episode when trazodone was used. There was no recurrence of syncope after the trazodone was discontinued. Discussion: The syncopal episode could have resulted from either trazodone or congenital heart disease, but it most likely resulted from a trazodone–congenital heart disease interaction. Trazodone is not cardiotoxic in most patients; our patient was probably vulnerable to the cardiotoxic effects of trazodone due to congenital cardiac defects. Conclusions: Trazodone can precipitate arrhythmias or syncope in susceptible patients with heart disease and should be prescribed cautiously in patients with congenital heart disease. In such cases, it may be safer to use a selective serotonin-reuptake inhibitor.

scholarly journals Congenital Heart Disease and Surgical Outcome in Down Syndrome

2021 ◽  
Author(s):  
Zainab Al-Suhaymi
Keyword(s):  
Congenital Heart Disease ◽  
Down Syndrome ◽  
Heart Disease ◽  
Congenital Heart ◽  
Current Knowledge ◽  
Innovative Technology ◽  
Mortality And Morbidity ◽  
Cardiac Anomalies ◽  
Congenital Cardiac Anomalies ◽  
Causes Of Mortality

The prevalence of congenital heart disease has accounted for nearly one-third of all significant congenital anomalies worldwide. The first report about an association between cardiac anomalies and Down Syndrome was in (1876). Ten years after discovering of Down Syndrome and the credit of association between congenital cardiac anomalies and mongolism was suggested in (1894) by Garrod. There many studies performed to identify a correlation between genotype and phenotype in Down Syndrome, little is known about cardiovascular phenotype in Down Syndrome. Congenital heart disease is considered one of the highest causes of mortality and morbidity in Down Syndrome compared to patients with the same lesion of non-down. There is a big debate about surgical management and considered them as risk factors of surgery with precaution and recent technology, Down Syndrome considered as a normal patient in prognosis. This chapter aimed to shed the light on congenital heart disease in Down Syndrome and current knowledge in specific mutations associated with them and how the effect of innovative technology and management to treat them end at the same outcome and sometimes better based on recent research and Scoring System.

COR PULMONALE IN INFANCY SIMULATING CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1954 ◽  
Vol 14 (6) ◽  
pp. 587-601
Author(s):  
IAN MAXWELL ◽  
REGINALD WILSON
Keyword(s):  
Congenital Heart Disease ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Clinical Picture ◽  
Congenital Heart ◽  
Cor Pulmonale ◽  
The Other ◽  
Vascular Lesions ◽  
Cardiac Anomalies ◽  
Congenital Cardiac Anomalies

1. Two cases of pulmonary arteriolar obstruction associated with hypertension of the lesser circulation have been described. Both cases were considered during life to be suffering from some form of congenital heart disease. 2. The pathogenesis of the pulmonary vascular lesions has been discussed. In one case, the lesion appears to have been a congenital dysplasia of arterioles throughout both lungs. In the other necrotizing arteriolitis was present in one lung which was also atelectatic. It was absent in the other well aerated lung though vascular lesions associated with pulmonary hypertension were present bilaterally. 3. The clinical picture of these patients has been described. It is suggested that this is sufficiently distinctive to permit clinical recognition and differentiation from congenital cardiac anomalies.

scholarly journals Personalized Genetic Diagnosis of Congenital Heart Defects in Newborns

2021 ◽  
Vol 11 (6) ◽  
pp. 562
Author(s):  
Olga María Diz ◽  
Rocio Toro ◽  
Sergi Cesar ◽  
Olga Gomez ◽  
Georgia Sarquella-Brugada ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart Defects ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Heart Defects ◽  
Genetic Diagnosis ◽  
Single Nucleotide Variants ◽  
Personalized Approach

Congenital heart disease is a group of pathologies characterized by structural malformations of the heart or great vessels. These alterations occur during the embryonic period and are the most frequently observed severe congenital malformations, the main cause of neonatal mortality due to malformation, and the second most frequent congenital malformations overall after malformations of the central nervous system. The severity of different types of congenital heart disease varies depending on the combination of associated anatomical defects. The causes of these malformations are usually considered multifactorial, but genetic variants play a key role. Currently, use of high-throughput genetic technologies allows identification of pathogenic aneuploidies, deletions/duplications of large segments, as well as rare single nucleotide variants. The high incidence of congenital heart disease as well as the associated complications makes it necessary to establish a diagnosis as early as possible to adopt the most appropriate measures in a personalized approach. In this review, we provide an exhaustive update of the genetic bases of the most frequent congenital heart diseases as well as other syndromes associated with congenital heart defects, and how genetic data can be translated to clinical practice in a personalized approach.

CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1950 ◽  
Vol 6 (2) ◽  
pp. 299-304
Author(s):  
STANLEY GIBSON
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Private Practice ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Pediatric Practice ◽  
Medical Centers ◽  
Additional Burden ◽  
Cardiac Diagnosis ◽  
Cardiovascular Anomalies

A short while ago, I asked a busy pediatrician of long experience how many "blue babies" he had seen in the course of his practice. He thought for a moment, then replied, "Four." Since that time I have made several other inquiries among my pediatric associates and have been surprised to find how small a number of cases of congenital heart disease they have had in their private practice. Yet if some stranger from another planet should visit Dr. Taussig's clinic, he might well conclude that congenital heart disease is as frequent as measles. The concentration of cases in a few medical centers throughout the country has doubtless given a false impression of the frequency and importance of congenital malformations of the heart. If then the problem represents so small a portion of general pediatric practice, one may fairly ask whether the already overworked children's specialist should undertake an additional burden. He is apt, too, to be discouraged when he contemplates some of the special technics and gadgets which have become popular in cardiac diagnosis. Let me hasten to assure him that his feeling of frustration is no more acute than that of many of us of the older generation when some of our chemical pediatricians begin to toss their atomic weights around and overwhelm us with millimols and milliequivalents. I wish, however, to emphasize the fact that it requires very little time and effort to have a good working knowledge of the diagnosis of most of the congenital cardiovascular anomalies which lend themselves to correction or improvement by surgical means.

scholarly journals Updates in Congenital Heart Disease: Can Outcomes Improve?

2019 ◽  
Vol 36 (S 02) ◽  
pp. S22-S28
Author(s):  
Gerard R. Martin ◽  
Russell R. Cross ◽  
Lisa A. Hom ◽  
Darren Klugman
Keyword(s):  
Intensive Care Unit ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
First Year ◽  
Cardiac Intensive Care Unit ◽  
Cardiac Intensive Care ◽  
First Year Of Life ◽  
Pulse Oximetry Screening

AbstractDespite numerous advances in medical and surgical management, congenital heart disease (CHD) remains the number one cause of death in the first year of life from congenital malformations. The current strategies used to approach improving outcomes in CHD are varied. This article will discuss the recent impact of pulse oximetry screening for critical CHD, describe the contributions of advanced cardiac imaging in the neonate with CHD, and highlight the growing importance of quality improvement and safety programs in the cardiac intensive care unit.

scholarly journals Congenital heart disease and pregnancy

2019 ◽  
Vol 4 (3) ◽  
pp. 102-112
Author(s):  
E. V. Rudaeva ◽  
V. G. Mozes ◽  
V. V. Kashtalap ◽  
I. S. Zakharov ◽  
S. I. Yelgina ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Intrauterine Growth Restriction ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Heart Defects ◽  
Intrauterine Growth ◽  
Increased Risk ◽  
Different Populations ◽  
European Society Of Cardiology

Annually, there > 30,000 infants are born with congenital heart defects; in different populations, the prevalence of congenital heart disease (CHD) varies from 2.4 to 14.15%. Women with CHD planning pregnancy are at increased risk of heart failure, arrhythmias, cerebrovascular disease, and embolism. In such patients, pregnancy course is complicated by intrauterine growth restriction, pre-eclampsia, and preterm birth. Their newborns generally have a low birth weight and high risk of congenital malformations including heart defects. European Society of Cardiology (ESC) developed risk assessment-based guidelines to optimise the management of pregnant women with CHD. This approach requires a cooperation of obstetrician-gynecologists, general practitioners, and cardiologists.

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