Defining Cerebrospinal Fluid White Blood Cell Count Reference Values in Neonates and Young Infants

✓ Experience with large cerebral abscesses in six newborn or very young infants is the basis for this report and discussion. Hydrocephalus, an afebrile state, and an elevated white blood cell count were characteristic. Diagnosis by aspiration was usually fortuitous in the process of subdural tap or ventriculography. Treatment by multiple aspirations was reasonably successful, but ultimate excision of the shrunken abscess may be wise. In only one case was the source of infection obvious.

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Evaluation of Cerebrospinal Fluid White Blood Cell Count Criteria for Use of the BioFire® FilmArray® Meningitis/Encephalitis Panel in Immunocompromised and Non-immunocompromised Patients

Diagnostic Microbiology and Infectious Disease ◽

10.1016/j.diagmicrobio.2021.115605 ◽

2021 ◽

pp. 115605

Author(s):

Randy McCreery ◽

Lindsey Nielsen ◽

Dillon Clarey ◽

Caitlin Murphy ◽

Trevor C. Van Schooneveld

Keyword(s):

Cerebrospinal Fluid ◽

Blood Cell ◽

Cell Count ◽

White Blood Cell Count ◽

White Blood Cell ◽

Immunocompromised Patients ◽

Blood Cell Count

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LACK OF VALIDITY OF STANDARD CORRECTIONS FOR WHITE BLOOD CELL COUNT OF BLOOD-CONTAMINATED CEREBROSPINAL FLUID IN INFANTS

The Pediatric Infectious Disease Journal ◽

10.1097/00006454-198411000-00031 ◽

1984 ◽

Vol 3 (6) ◽

pp. 599

Author(s):

&NA;

Keyword(s):

Cerebrospinal Fluid ◽

Blood Cell ◽

Cell Count ◽

White Blood Cell Count ◽

White Blood Cell ◽

Blood Cell Count

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Leptospirosis meningitis transmission from a pet mouse: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-019-2265-7 ◽

2019 ◽

Vol 13 (1) ◽

Author(s):

Anne Christine Nordholm ◽

Lars Haukali Omland ◽

Steen Villumsen ◽

Imad Al-Subeihe ◽

Terese L. Katzenstein

Keyword(s):

Cerebrospinal Fluid ◽

Case Report ◽

Blood Cell ◽

Cell Count ◽

White Blood Cell Count ◽

White Blood Cell ◽

Healthy Woman ◽

Blood Cell Count ◽

Wide Range ◽

Pet Rodents

Abstract Background Leptospirosis is a reemerging zoonosis with a worldwide distribution and a wide range of clinical manifestations. We report a case of leptospirosis meningitis in a previously healthy woman infected by her pet mouse. Case presentation A 27-year-old Caucasian woman with pet mice presented to our institute with a 1 week history of fever, headache, myalgia, vomiting, diarrhea, and dark urine. Her admission examination revealed neck stiffness, conjunctivitis, and icteric sclera. Her liver enzymes, bilirubin, white blood cell count, and C-reactive protein were elevated. Her cerebrospinal fluid showed an elevated white blood cell count. Polymerase chain reactions using her cerebrospinal fluid, blood, and urine showed negative results for leptospirosis, but the result of her microagglutination test was positive for Leptospira interrogans serovar sejroe with a more than threefold increase in paired sera. The patient was treated with ceftriaxone for 1 week, and her condition steadily improved. Conclusions This case report raises awareness of pet rodents as sources of leptospirosis. Leptospirosis meningitis should be considered in patients with meningeal symptoms and pet rodents.

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