Evaluation of Cerebrospinal Fluid White Blood Cell Count Criteria for Use of the BioFire® FilmArray® Meningitis/Encephalitis Panel in Immunocompromised and Non-immunocompromised Patients

Author(s):  
Randy McCreery ◽  
Lindsey Nielsen ◽  
Dillon Clarey ◽  
Caitlin Murphy ◽  
Trevor C. Van Schooneveld
2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Anne Christine Nordholm ◽  
Lars Haukali Omland ◽  
Steen Villumsen ◽  
Imad Al-Subeihe ◽  
Terese L. Katzenstein

Abstract Background Leptospirosis is a reemerging zoonosis with a worldwide distribution and a wide range of clinical manifestations. We report a case of leptospirosis meningitis in a previously healthy woman infected by her pet mouse. Case presentation A 27-year-old Caucasian woman with pet mice presented to our institute with a 1 week history of fever, headache, myalgia, vomiting, diarrhea, and dark urine. Her admission examination revealed neck stiffness, conjunctivitis, and icteric sclera. Her liver enzymes, bilirubin, white blood cell count, and C-reactive protein were elevated. Her cerebrospinal fluid showed an elevated white blood cell count. Polymerase chain reactions using her cerebrospinal fluid, blood, and urine showed negative results for leptospirosis, but the result of her microagglutination test was positive for Leptospira interrogans serovar sejroe with a more than threefold increase in paired sera. The patient was treated with ceftriaxone for 1 week, and her condition steadily improved. Conclusions This case report raises awareness of pet rodents as sources of leptospirosis. Leptospirosis meningitis should be considered in patients with meningeal symptoms and pet rodents.


PEDIATRICS ◽  
2010 ◽  
Vol 125 (2) ◽  
pp. 257-264 ◽  
Author(s):  
L. A. Kestenbaum ◽  
J. Ebberson ◽  
J. J. Zorc ◽  
R. L. Hodinka ◽  
S. S. Shah

2020 ◽  
Vol 414 ◽  
pp. 116876
Author(s):  
Bernhard Neumann ◽  
Tim Steinberg ◽  
De-Hyung Lee ◽  
Johanna Kress ◽  
Marco Kufner ◽  
...  

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