Iron Supplements Reduce the Risk of Iron Deficiency Anemia in Marginally Low Birth Weight Infants

PEDIATRICS ◽  
2010 ◽  
Vol 126 (4) ◽  
pp. e874-e883 ◽  
Author(s):  
S. Berglund ◽  
B. Westrup ◽  
M. Domellof
Author(s):  
Mateusz Szudzik ◽  
Rafał R. Starzyński ◽  
Aneta Jończy ◽  
Rafał Mazgaj ◽  
Małgorzata Lenartowicz ◽  
...  

In pigs, iron deficiency anemia (IDA) is the most prevalent deficiency disorder during the early postnatal period frequently developing into a critical illness. Meanwhile, in humans, only low-birth-weight infants, including premature infants are especially susceptible to developing IDA. In both human and pig neonates, the initial cause of IDA is low birth iron stores. In piglets this shortage of stored iron results mainly from genetic selection over the past few decades for large litter size and high birth weight. In consequence, pregnant sows cannot provide sufficient amount of iron to the increasing number of developing fetuses. Supplementation with iron is a common practice for the treatment of IDA in piglets. For decades, the preferred procedure for delivering iron supplements during early life stages has been through the intramuscular injection of large amount of iron dextran. However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron. New iron supplements are considered now with the aim to combine improvement of hematological status, blunting hepcidin expression, and minimizing toxicity of the administered iron. We propose that iron-deficient piglets constitute a convenient animal model for performing pre-clinical studies with iron supplements.


2021 ◽  
Vol 05 (1) ◽  
pp. 1-13
Author(s):  
Sahar Talab ◽  
Sarab Jasim

Birth weight is a crucial determinant of the developmental potential of the newborn. Birth weight is the body weight of a baby at its birth. The range of normal is between 2.5 and 4.5 kilograms (5.5 and 9.9 lb). On average, babies of south Asian and Chinese heritage weigh about 3.26 kilograms (7.2 lb). Abnormal newborn weights are associated with negative effects on the health and survival of the baby and the mother. World Health Organization has defined low birth weight as birth weight less than 2,500 grams. Giving birth to a low-birth-weight infant is influenced by several factors. This study aimed to identify key determinants that influence the frequency of normal and low birth weight in Salah Al-Deen general Hospital in Tikrit city-Iraq. This study is a Cross- sectional study, was conducted in obstetric department in Salah Al-Deen general hospital during the period from 1st Feb to the 31st of August 2020. The study sample included full term babies (gestational age 37-42 week) chosen by using a convenient sampling method selecting 197 delivered babies with their mothers. Data collection done by face-to-face interview, using the structured questionnaire developed by the researcher include the following information: Information regarding the mother included demographic variables, reproductive health, medical and obstetrical history and antenatal care visits, use of ferrous sulfate and other supplements during pregnancy. Birth weight was measured at birth, to the nearest 50 g, with the nude infant lying on the available scale. Zero adjustment of the scale was frequently done to ensure accuracy of the readings. Birth weight was categorized into two as low birth weight (birth weight < 2500 grams), and normal birth weight (birth weight ≥ 2500 grams). The current study showed that prevalence of low birth weight was (2.4%), macrosomia (15.6%) and normal birth weight was (82%). The study showed that the low birth weight was higher among primigravida (3.4%), than multigravida women (1.7%) and that the low birth weight was higher among 1st and 2nd birth order (3.4%), (6.7%) respectively while it was (0%) among the 3rd baby order. Previous history of Diabetes Mellitus was associated with 0(0%) low birth weight babies and (2.6%) of those women without Diabetes Mellitus had low birth weight babies. Those with history of iron deficiency anemia was more prone to had babies with low birth weight (3.1%), versus those without history of iron deficiency anemia (1.3%). Those with history of hypertension more prone to had babies with low birth weight (4%), versus those without history of iron deficiency anemia (2.2%). The current study showed that those with ferrous sulfate supplements had lower proportion of babies with low birth weight (1.2%), versus those without supplements (7.7%), this relation statistically significant. This study has demonstrated that the younger maternal age, mother with diabetes mellitus, hypertension and irregular antenatal care had babies with lower birth weight. Previous history of low birth weight also is a predisposing factor for low birth weight.


2018 ◽  
Vol 11 (4) ◽  
pp. 128 ◽  
Author(s):  
Mateusz Szudzik ◽  
Rafał Starzyński ◽  
Aneta Jończy ◽  
Rafał Mazgaj ◽  
Małgorzata Lenartowicz ◽  
...  

In pigs, iron deficiency anemia (IDA) is the most prevalent deficiency disorder during the early postnatal period, frequently developing into a serious illness. On the other hand, in humans, only low-birth-weight infants, including premature infants, are especially susceptible to developing IDA. In both human and pig neonates, the initial cause of IDA is low birth iron stores. In piglets this shortage of stored iron results mainly from genetic selection over the past few decades for large litter sizes and high birth weights. As a consequence, pregnant sows cannot provide a sufficient amount of iron to the increasing number of developing fetuses. Supplementation with iron is a common practice for the treatment of IDA in piglets. For decades, the preferred procedure for delivering iron supplements during early life stages has been through the intramuscular injection of a large amount of iron dextran. However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron. New iron supplements are considered herein with the aim to combine the improvement of hematological status, blunting of hepcidin expression, and minimizing the toxicity of the administered iron. We propose that iron-deficient piglets constitute a convenient animal model for performing pre-clinical studies with iron supplements.


2019 ◽  
Vol 10 (2) ◽  
pp. 723-732 ◽  
Author(s):  
Fengzheng Gao ◽  
Wei Guo ◽  
Mingyong Zeng ◽  
Yinong Feng ◽  
Guangxin Feng

Microalgae are functional iron nutritive fortifiers that can supply more intestinal nanosized iron.


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