Effect of microalgae as iron supplements on iron-deficiency anemia in rats

2019 ◽  
Vol 10 (2) ◽  
pp. 723-732 ◽  
Author(s):  
Fengzheng Gao ◽  
Wei Guo ◽  
Mingyong Zeng ◽  
Yinong Feng ◽  
Guangxin Feng

Microalgae are functional iron nutritive fortifiers that can supply more intestinal nanosized iron.


Talanta ◽  
2017 ◽  
Vol 170 ◽  
pp. 523-529 ◽  
Author(s):  
Uenderson Araujo-Barbosa ◽  
Elena Peña-Vazquez ◽  
Maria Carmen Barciela-Alonso ◽  
Sergio Luis Costa Ferreira ◽  
Ana Maria Pinto dos Santos ◽  
...  






2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qi Zhang ◽  
Xiao-Min Lu ◽  
Min Zhang ◽  
Chen-Ying Yang ◽  
Si-Yuan Lv ◽  
...  

AbstractIron deficiency anemia (IDA) is a common micronutrient deficiency among pregnant women with severe consequences including impaired immuno-inflammatory system, premature birth, fetal death etc. The present study aimed to investigate the effects of three iron supplements on IDA female rats and their offspring. The IDA female rat model was established with low iron diet and the rats were then mated. After pregnancy, rats were fed diets containing different iron supplements (iron polysaccharide complex, iron protein succinylate and ferrous sulfate) until their offspring were 42 days old. Pregnancy outcomes, haematological, iron metabolism, physical and neurological development indexes were determined. The results showed that all three iron supplements improved the levels of hematological parameters of both mother and offspring rats. After iron supplementation, serum iron, transferrin saturation and serum ferritin levels were increased compared with the IDA group. The level of ferritin light chain in the liver and spleen of both mother and offspring rats in iron supplemented groups was significantly higher than that of the IDA group. The average number of born alive per litter in the iron treatment groups was significantly higher than that in the IDA group. Iron supplements also improved the physical growth and neurobehavioral development of offspring rats. It was also found that iron supplementation improved the expression of ferritin light chain and the synaptic growth associated proteins in the brain and hippocampus. No significant difference was found in the efficacy of three iron supplements. These results suggest that pregnant and postpartum IDA affects pregnancy outcomes, offspring physical development and causes neural impairment. Sufficient iron supplementation can significantly improve IDA and its adverse effects on both mother and offspring.



2021 ◽  
Vol 9 (2) ◽  
pp. 159-162
Author(s):  
Hossein Karami ◽  
◽  
Mohammad Naderisorki ◽  
Maryam Ghasemi ◽  
Mobin Ghazaiean ◽  
...  

One of the most common nutritional deficiencies worldwide is iron deficiency. Fatigue, pallor, vertigo, dyspnea, cold intolerance, lethargy, palpitation, headache, and the pallor of the mucous membranes or nail beds are the most frequent symptoms and signs of iron deficiency. Thrombocytosis is commonly observed in iron deficiency anemia; it seems that erythropoietin plays the main role in this respect. Furthermore, thrombocytopenia and even leukopenia have been reported in iron deficiency; however, pancytopenia is a very rare condition. In this report, we presented two unusual cases of pancytopenia due to severe iron deficiency that improved after treatment with oral iron supplements. Iron deficiency anemia, if sufficiently severe, may be associated with reduced platelet and leukocyte counts. Accordingly, this condition should be considered as a differential diagnosis in all patients with pancytopenia.



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