Occurrence of Acute Glomerulonephritis in Sibling Contacts of Children with Sporadic Acute Glomerulonephritis

PEDIATRICS ◽  
1967 ◽  
Vol 40 (6) ◽  
pp. 1028-1030
Author(s):  
WARREN F. DODGE ◽  
BENJAMIN H. SPARGO ◽  
LUTHER B. TRAVIS
Keyword(s):  
Renal Biopsy ◽  
Index Case ◽  
The Other ◽  
Acute Glomerulonephritis ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Close Observation

Additional cases of acute glomerulonephritis in sibling contacts were observed in from one fourth (proven by renal biopsy) to one half (proven and suspected) of the index case sibships examined. These data suggest that the occurrence of acute glomerulonephritis in family contacts of children with sporadic acute poststreptococcal glomerulonephritis is so common as to warrant close observation of the other siblings.

scholarly journals C3 and C4 Complements in Glomerular Disorders in Children

2017 ◽  
Vol 18 (3-4) ◽  
pp. 75
Author(s):  
H. Alatas ◽  
I.G.N. Wila Wirya ◽  
T. Tambunan
Keyword(s):  
Nephrotic Syndrome ◽  
Child Health ◽  
Normal Level ◽  
Membranoproliferative Glomerulonephritis ◽  
Kidney Diseases ◽  
Immunosuppressive Treatment ◽  
The Other ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Almost All

Seventy children who were hospitalized for kidney diseases in the Nephrological ward Department of Child Health, University of Indonesia, Jakarta were used in this study. Thirty seven patients sufferfng from acute poststreptococcal Glomerulonephritis (A.G.N.), 3 patients with Membranoproliferative Glomerulonephritis (M.P.G.N.) and 30 patients with Nephrotic Syndrome due to other causes were examined for complement concentration. A total of 80 samples were examined for C3 and 25 samples for C4 concentration using the immunediffusion plates. Almost all patients with A.G.N. and M.P.G.N. showed depression of C3. C4 concentration was normal except in 2 patients, 1 with A.G.N. and the other With M.P.G.N. This suggest activation of complement at the C3 level by the alternating pathway in most of the patients. C3 concentration in A.G.N. patients returned to normal after 8-10 weeks. In MPGN the depression was persistent in 2 patients, while in 1 patient it returned to normal level after 3 months of Immunosuppressive treatment.

scholarly journals Acute poststreptococcal glomerulonephritis: public health implications of recent clusters in New South Wales and epidemiology of hospital admissions

2000 ◽  
Vol 126 (3) ◽  
pp. 365-372 ◽  
Author(s):  
D. J. MUSCATELLO ◽  
K.-A. O'GRADY ◽  
K. NEVILLE ◽  
J. McANULTY
Keyword(s):  
Hospital Admissions ◽  
New South ◽  
New South Wales ◽  
Acute Glomerulonephritis ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Rural Town ◽  
South Wales ◽  
Group A ◽  
Aboriginal Children

Acute poststreptococcal glomerulonephritis (APSGN) is an inflammatory kidney condition that can complicate Group A streptococcal infections. Two clusters of APSGN occurred recently in New South Wales (NSW), Australia; one in a rural town in December 1999 and the other in a Sydney suburb in January 2000. We interviewed carers of the affected children but found no common exposures except three of the Sydney cases were cousins in frequent contact. To assess the probability of these clusters occurring, we analysed hospital admissions for acute glomerulonephritis, as a proxy for APSGN in younger patients. The incidence of acute glomerulonephritis in NSW during 1989/90–1997/8 in residents aged under 20 years was 2·2/100000/year (95% CI 2·0–2·5). Incidence was highest in children aged 5–9 years, boys and Aboriginal children. We found no evidence for other clusters during that period. The recent clusters highlight the continued potential for unexpected future outbreaks of APSGN.

ELEVATED SERUM IgA GLOBULIN IN ANAPHYLACTOID PURPURA

PEDIATRICS ◽  
1971 ◽  
Vol 47 (6) ◽  
pp. 1023-1028
Author(s):  
Carl W. Trygstad ◽  
E. Richard Stiehm
Keyword(s):  
Skin Rash ◽  
Elevated Serum ◽  
Serum Levels ◽  
The Other ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Serum Iga ◽  
Immunoglobulin Levels

Serial determinations of serum levels of IgA, IgD, IgG, and IgM globulin were performed on 27 children with anaphylactoid purpura and two children with acute poststreptococcal glomerulonephritis. Ten of 20 children with anaphylactoid purpura seen within 3 months of the onset of the skin rash had significant elevations of their serum IgA globulin. The other immunoglobulin levels were normal in the remaining children and those with acute poststreptococcal glomerulonephritis. The selective elevation of serum IgA globulin may be related to the pathogenesis of anaphylactoid purpura.

scholarly journals The occurrence of a protein in the extracellular products of streptococci isolated from patients with acute glomerulonephritis.

1979 ◽  
Vol 149 (2) ◽  
pp. 459-472 ◽  
Author(s):  
H Villarreal ◽  
V A Fischetti ◽  
I van de Rijn ◽  
J B Zabriskie
Keyword(s):  
Present Report ◽  
Sodium Dodecyl ◽  
Protein Band ◽  
Extracellular Proteins ◽  
Acute Glomerulonephritis ◽  
Marked Variation ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Single Protein ◽  
Different Strains

The present report compares the extracellular proteins of streptococci by sodium dodecyl sulfate polyacrylamide electrophoresis. A marked variation in the streptococcal extracellualr proteins (SEP) of different strains was detected, even in strains of similar serotypes. It was possible, however, to identify a single protein band that occurred predominantly in the SEP of strains isolated from patients with acute poststreptococcal glomerulonephritis (APSGN). This protein was generally not produced by streptococci obtained from patients without this disease. It appears to be immunologically similar in the various serotypes of streptococci isolated from patients with APSGN and can be demonstrated by immunofluorescence techniques to be present in the glomeruli of these patients.

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