scholarly journals C3 and C4 Complements in Glomerular Disorders in Children

2017 ◽  
Vol 18 (3-4) ◽  
pp. 75
Author(s):  
H. Alatas ◽  
I.G.N. Wila Wirya ◽  
T. Tambunan
Keyword(s):  
Nephrotic Syndrome ◽  
Child Health ◽  
Normal Level ◽  
Membranoproliferative Glomerulonephritis ◽  
Kidney Diseases ◽  
Immunosuppressive Treatment ◽  
The Other ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Almost All

Seventy children who were hospitalized for kidney diseases in the Nephrological ward Department of Child Health, University of Indonesia, Jakarta were used in this study. Thirty seven patients sufferfng from acute poststreptococcal Glomerulonephritis (A.G.N.), 3 patients with Membranoproliferative Glomerulonephritis (M.P.G.N.) and 30 patients with Nephrotic Syndrome due to other causes were examined for complement concentration. A total of 80 samples were examined for C3 and 25 samples for C4 concentration using the immunediffusion plates. Almost all patients with A.G.N. and M.P.G.N. showed depression of C3. C4 concentration was normal except in 2 patients, 1 with A.G.N. and the other With M.P.G.N. This suggest activation of complement at the C3 level by the alternating pathway in most of the patients. C3 concentration in A.G.N. patients returned to normal after 8-10 weeks. In MPGN the depression was persistent in 2 patients, while in 1 patient it returned to normal level after 3 months of Immunosuppressive treatment.

Occurrence of Acute Glomerulonephritis in Sibling Contacts of Children with Sporadic Acute Glomerulonephritis

PEDIATRICS ◽  
1967 ◽  
Vol 40 (6) ◽  
pp. 1028-1030
Author(s):  
WARREN F. DODGE ◽  
BENJAMIN H. SPARGO ◽  
LUTHER B. TRAVIS
Keyword(s):  
Renal Biopsy ◽  
Index Case ◽  
The Other ◽  
Acute Glomerulonephritis ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Close Observation

Additional cases of acute glomerulonephritis in sibling contacts were observed in from one fourth (proven by renal biopsy) to one half (proven and suspected) of the index case sibships examined. These data suggest that the occurrence of acute glomerulonephritis in family contacts of children with sporadic acute poststreptococcal glomerulonephritis is so common as to warrant close observation of the other siblings.

scholarly journals Hubungan antara Proteinuria dan Hipoalbuminemia pada Anak dengan Sindrom Nefrotik yang Dirawat di RSUP Dr. M. Djamil Padang periode 2009-2012

2013 ◽  
Vol 2 (2) ◽  
pp. 90
Author(s):  
Pratiwi Dian Pramana ◽  
Mayetti Mayetti ◽  
Husnil Kadri
Keyword(s):  
Nephrotic Syndrome ◽  
Clinical Symptoms ◽  
Secondary Data ◽  
Urinary Protein ◽  
The Other ◽  
Age Group ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
Almost All ◽  
The Relationship

AbstrakSindrom nefrotik terdiri dari proteinuria massif, hipoalbuminemia, edema, serta dapat disertai hiperkolesterolemia. Proteinuria merupakan gejala utama pada sindrom nefrotik, sedangkan gejala klinis lainnya dianggap sebagai manifestasi sekunder. Kehilangan protein melalui urin menyebabkan terjadinya hipoalbuminemia. Penelitian ini bertujuan mengidentifikasi hubungan antara proteinuria dan hipoalbuminemia pada anak dengan sindrom nefrotik. Metode yang digunakan adalah studi retrospektif dengan desain Cross Sectional. Data sekunder diambil dari rekam medik pasien yang didiagnosis sebagai Sindrom Nefrotik Anak di Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil Padang Periode Januari 2009 - April 2012. Penelitian berlangsung dari Oktober 2011- Desember 2012. Hasil penelitian menunjukan insiden tertinggi sindrom nefrotik pada kelompok umur >6 tahun terutama pada anak laki-laki dengan rasio 1,43:1. Sebagian besar pasien memiliki kadar protein urin semikuantitatif +3 dengan rata-rata kadar protein urin kuantitatif 3,121 ± 2,157 gr/24 jam. Hampir seluruh pasien mengalami hipoalbuminemia (98,2%). Analisis statistik menunjukkan tidak terdapat hubungan yang bermakna antara proteinuria dan hipoalbuminemia (p > 0.05). Hal ini mungkin disebabkan oleh jumlah subjek yang kurang, sehingga penelitian selanjutnya diharapkan berlangsung lebih lama agar didapatkan jumlah subjek yang lebih besar.Kata kunci: Anak dengan sindrom nefrotik, Proteinuria, HipoalbuminemiaAbstractNephrotic syndrome consist of massive proteinuria, hypoalbuminemia, edema, and may be accompanied by hypercholesterolemia. Proteinuria is a major symptom of nephrotic syndrome, while the other clinical symptoms considered secondary manifestations. Loss of protein in the urine leads to hypoalbuminemia. This study aims to identify the relationship between proteinuria and hypoalbuminemia in children with Nephrotic Syndrome. Method of this research performed a retrospective study with cross sectional design. Secondary data were taken from medical record of patients that were diagnosed as Nephrotic Syndrome Children in General Hospital Dr. M. Djamil Padang period January 2009 - April 2012. The study was held on October 2011 - December 2012. The result of this study showed that the highest incidence of Nephrotic Syndrome in the age group >6 years old especially in male with the ratio 1,43:1. Most of patients have levels of semiquantitative urinary protein +3 with average levels of quantitative urinary protein 3.121 ± 2.157 gr/24 hours. Almost all of the patients had hypoalbuminemia (98.2%). Statistical analysis showed that there was no significant relationship between proteinuria and hypoalbuminemia (p> 0.05). This may be due to the less number of subjects, so further research is expected to last much longer in order to have a larger number of subjects.Keywords:Nephrotic syndrome children, Proteinuria, Hypoalbuminemia

scholarly journals The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan Renal Biopsy Registry and Japan Kidney Disease Registry

2020 ◽  
Vol 24 (11) ◽  
pp. 1058-1068
Author(s):  
Takaya Ozeki ◽  
◽  
Shoichi Maruyama ◽  
Michio Nagata ◽  
Akira Shimizu ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Renal Biopsy ◽  
Kidney Diseases ◽  
Immunosuppressive Treatment ◽  
Laboratory Data ◽  
First Year ◽  
Disease Registry ◽  
Web Based ◽  
Registry System ◽  
Almost All

Abstract Background The Japan Renal Biopsy Registry (J-RBR), the first nation-wide registry of renal biopsies in Japan, was established in 2007, and expanded to include non-biopsy cases as the Japan Kidney Disease Registry (J-KDR) in 2009. The J-RBR/J-KDR is one of the biggest registries for kidney diseases. It has revealed the prevalence and distribution of kidney diseases in Japan. This registry system was meant to be revised after 10 years. Methods In 2017, the Committees of the Japanese Society of Nephrology started a project for the revision of the J-RBR/J-KDR. The revised system was designed in such a way that the diagnoses of the patients could be selected from the Diagnosis Panel, a list covering almost all known kidney diseases, and focusing on their pathogenesis rather than morphological classification. The Diagnosis Panel consists of 22 categories (18 glomerular, 1 tubulointerstitial, 1 congenital/genetical, 1 transplant related, and 1 other) and includes 123 diagnostic names. The items for clinical diagnosis and laboratory data were also renewed, with the addition of the information on immunosuppressive treatment. Results The revised version of J-RBR/J-KDR came into use in January 2018. The number of cases registered under the revised system was 2748 in the first year. The total number of cases has reached to 43,813 since 2007. Conclusion The revised version 2018 J-RBR/J-KDR system attempts to cover all kidney diseases by focusing on their pathogenesis. It will be a new platform for the standardized registration of kidney biopsy cases that provides more systemized data of higher quality.

ELEVATED SERUM IgA GLOBULIN IN ANAPHYLACTOID PURPURA

PEDIATRICS ◽  
1971 ◽  
Vol 47 (6) ◽  
pp. 1023-1028
Author(s):  
Carl W. Trygstad ◽  
E. Richard Stiehm
Keyword(s):  
Skin Rash ◽  
Elevated Serum ◽  
Serum Levels ◽  
The Other ◽  
Poststreptococcal Glomerulonephritis ◽  
Acute Poststreptococcal Glomerulonephritis ◽  
Serum Iga ◽  
Immunoglobulin Levels

Serial determinations of serum levels of IgA, IgD, IgG, and IgM globulin were performed on 27 children with anaphylactoid purpura and two children with acute poststreptococcal glomerulonephritis. Ten of 20 children with anaphylactoid purpura seen within 3 months of the onset of the skin rash had significant elevations of their serum IgA globulin. The other immunoglobulin levels were normal in the remaining children and those with acute poststreptococcal glomerulonephritis. The selective elevation of serum IgA globulin may be related to the pathogenesis of anaphylactoid purpura.

scholarly journals A Clinico-Pathological Correlation of Childhood Primary Nephrotic Syndrome in Jakarta

2019 ◽  
Vol 33 (7-8) ◽  
pp. 150-8
Author(s):  
I. G. N. Wila Wirya
Keyword(s):  
Nephrotic Syndrome ◽  
Kidney Disease ◽  
Child Health ◽  
Medical School ◽  
Membranoproliferative Glomerulonephritis ◽  
Clinical Laboratory ◽  
International Study ◽  
Histopathological Changes ◽  
Primary Nephrotic Syndrome ◽  
Pathological Characteristics

Three hundred and sixty-four out of 547 children with primary nephrotic syndrome (PNS) treated at the Department of Child Health, Medical School, University of Indonesia between January 1970 and December 1979, were biopsied. The clinical, laboratory, and pathological characteristics of these patients were evaluated and compared with those reported by the International Study of Kidney Disease in Children (ISKOC, 1978) comprising children of Western countries with PNS. Results of this study showed that the spectrum of the histopathological changes in the 2 study populations was slightly different. Clinical and laboratory characteristics of certain types of PNS also showed some differences compared with those of ISKDC report. Patients with non-minimal changes nephrotic syndrome (NMCNS) were more frequently found in this study, and they were older than those of ISKDC report, i.e., more children < 6 years of age were affected with this disease in Jakarta. Similarly, this study showed that patients with minimal changes nephrotic syndrome (MCNS) were older than those of ISKDC report; the peak age of Western patients was less than 6 years. Patients with focal segmental glomerulosclerosis (FSGS) and membranoproliferative glomerulonephritis (MPGN) reported by ISKDC were more severe than those of this study as far as clinical and laboratory characteristics were concerned. The causes of these clinical and histopathological discrepancies between the two studies need to be further elucidated.

Platelet Suruival and Function in Rats with Enhanced Thrombotic Tendency

1985 ◽  
Vol 54 (04) ◽  
pp. 739-743 ◽  
Author(s):  
Federica Delaini ◽  
Elisabetta Dejana ◽  
Ine Reyers ◽  
Elisa Vicenzi ◽  
Germana De Bellis Vitti ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Nephrotic Syndrome ◽  
Platelet Function ◽  
Laboratory Tests ◽  
Thrombus Formation ◽  
The Other ◽  
Mean Survival Time ◽  
The Mean ◽  
And Function ◽  
Thrombotic Tendency

SummaryWe have investigated the relevance of some laboratory tests of platelet function in predicting conditions of thrombotic tendency. For this purpose, we studied platelet survival, platelet aggregation in response to different stimuli, TxB2 and 6-keto-PGFlα production in serum of rats bearing a nephrotic syndrome induced by adriamycin. These animals show a heavy predisposition to the development of both arterial and venous thrombosis. The mean survival time was normal in nephrotic rats in comparison to controls. As to aggregation tests, a lower aggregating response was found in ADR-treated rats using ADP or collagen as stimulating agents. With arachidonic acid (AA) we observed similar aggregating responses at lower A A concentrations, whereas at higher AA concentrations a significantly lower response was found in nephrotic rats, despite their higher TxB2 production. Also TxB2 and 6-keto-PGFlα levels in serum of nephrotic rats were significantly higher than in controls. No consistent differences were found in PGI2-activity generated by vessels of control or nephrotic rats.These data show that platelet function may appear normal or even impaired in rats with a markedly increased thrombotic tendency. On the other hand, the significance of high TxB2 levels in connection with mechanisms leading to thrombus formation remains a controversial issue.

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