Committee on Drugs Attacked

PEDIATRICS ◽  
1974 ◽  
Vol 53 (6) ◽  
pp. 952-952
Author(s):  
Leon Oettinger
Keyword(s):  
Clinical Experience ◽  
Extensive Clinical Experience ◽  
Convulsive Threshold

I note Doctor Livingston's comments on the use of amphetamines in epilepsy and the Committee's reply. I would like to support Doctor Livingston's endorsement of the use of amphetamines in epilepsy. He and his colleagues wrote an article in the fifties on their use in petit mal. Laufer and Denhoff also indicated an increase in the convulsive threshold using a metrazol activation in hyperkinetic children. Although the Committee may not be aware of the literature concerning this, many of us who have had extensive clinical experience with epilepsy feel that the amphetamines are of value.

scholarly journals Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

2021 ◽  
Vol 18 (4) ◽  
pp. 1692
Author(s):  
Akylbek Sydykov ◽  
Argen Mamazhakypov ◽  
Abdirashit Maripov ◽  
Djuro Kosanovic ◽  
Norbert Weissmann ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
High Altitude ◽  
Clinical Experience ◽  
Current Knowledge ◽  
Hypoxic Pulmonary Vasoconstriction ◽  
Treatment Options ◽  
Right Heart Failure ◽  
Channel Blockers ◽  
The Right ◽  
Extensive Clinical Experience

Alveolar hypoxia is the most prominent feature of high altitude environment with well-known consequences for the cardio-pulmonary system, including development of pulmonary hypertension. Pulmonary hypertension due to an exaggerated hypoxic pulmonary vasoconstriction contributes to high altitude pulmonary edema (HAPE), a life-threatening disorder, occurring at high altitudes in non-acclimatized healthy individuals. Despite a strong physiologic rationale for using vasodilators for prevention and treatment of HAPE, no systematic studies of their efficacy have been conducted to date. Calcium-channel blockers are currently recommended for drug prophylaxis in high-risk individuals with a clear history of recurrent HAPE based on the extensive clinical experience with nifedipine in HAPE prevention in susceptible individuals. Chronic exposure to hypoxia induces pulmonary vascular remodeling and development of pulmonary hypertension, which places an increased pressure load on the right ventricle leading to right heart failure. Further, pulmonary hypertension along with excessive erythrocytosis may complicate chronic mountain sickness, another high altitude maladaptation disorder. Importantly, other causes than hypoxia may potentially underlie and/or contribute to pulmonary hypertension at high altitude, such as chronic heart and lung diseases, thrombotic or embolic diseases. Extensive clinical experience with drugs in patients with pulmonary arterial hypertension suggests their potential for treatment of high altitude pulmonary hypertension. Small studies have demonstrated their efficacy in reducing pulmonary artery pressure in high altitude residents. However, no drugs have been approved to date for the therapy of chronic high altitude pulmonary hypertension. This work provides a literature review on the role of pulmonary hypertension in the pathogenesis of acute and chronic high altitude maladaptation disorders and summarizes current knowledge regarding potential treatment options.

scholarly journals Extensive clinical experience: a simple guide to basal insulin adjustments for long-distance travel

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Jordan E Pinsker ◽  
Erik Becker ◽  
C Becket Mahnke ◽  
Michael Ching ◽  
Noelle S Larson ◽  
...  
Keyword(s):  
Clinical Experience ◽  
Basal Insulin ◽  
Long Distance ◽  
Distance Travel ◽  
Extensive Clinical Experience ◽  
Long Distance Travel

Pathophysiology of Involuntary Emotional Expression Disorder

CNS Spectrums ◽  
2007 ◽  
Vol 12 (S5) ◽  
pp. 17-22 ◽  
Author(s):  
Peter V. Rabins ◽  
David B. Arciniegas
Keyword(s):  
Clinical Experience ◽  
Significant Role ◽  
Emotional Expression ◽  
Symptom Control ◽  
Structure And Function ◽  
Sigma Receptor ◽  
Expression Systems ◽  
Inhibitory Mechanisms ◽  
And Function ◽  
Extensive Clinical Experience

AbstractExtensive clinical experience and research suggest that a cortico-limbic-subcortico-thalamic-ponto-cerebellar network plays a significant role in the expression of human emotions. This network includes specific cerebral, cerebellar, and brainstem areas and their multiple projections/pathways, with activity modulated through serotonergic, dopaminergic, glutamatergic, and possibly sigma receptor neurotransmitter systems. Disruptions of regulatory and inhibitory mechanisms in the structure and function of this network likely constitute a pathophysiological basis for the crying and laughing episodes characteristic of involuntary emotional expression disorder. Pharmacologic interventions targeting the neurochemical modulators of the emotional expression systems may afford opportunities for symptom control among persons affected by this disorder.

The Pathophysiology and Treatment of Drowning and Near-Drowning, by Jerome H. Modell, M.D. Springfield, Illinois: Charles C Thomas, 1971, 119 pp., $9.50

PEDIATRICS ◽  
1972 ◽  
Vol 50 (3) ◽  
pp. 509-509
Author(s):  
Samuel T. Giammona
Keyword(s):  
Fresh Water ◽  
Clinical Experience ◽  
Major Part ◽  
Sea Water ◽  
Scientific Information ◽  
Serum Electrolyte ◽  
Near Drowning ◽  
Electrolyte Disturbances ◽  
Laboratory Investigations ◽  
Extensive Clinical Experience

This is a timely, concise book concerning drowning and near-drowning in which the latest scientific information as well as discussion of previous and current concepts concerning these problems are presented lucidly. Dr. Modell has had extensive clinical experience in Florida handling the drowning and near-drowning victim. He devotes the major part of his presentation to an explanation, based on his laboratory investigations and review of other works, of the pathophysiology in drowning and near-drowning. Especially pertinent is the chapter on serum electrolyte changes, in which the differences between fresh water and sea water near-drowning reveal that correction of electrolyte disturbances is of secondary rather than primary importance in the treatment of most human victims in near-drowning as the changes attributed to the composition and the tonicity of the fluid aspirated are not as important as previously stressed.

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