The pediatrician and hypertension

PEDIATRICS ◽  
1975 ◽  
Vol 56 (1) ◽  
pp. 3-5
Author(s):  
Shiea C. Mitchell ◽  
S. Gilbert Blount ◽  
Sidney Blumenthal ◽  
Jullien I. E. Hoffman ◽  
Mary Jane Jesse ◽  
...  

Hypertension is one of the more common diseases affecting American adults. It is the cause of at least one fourth, and perhaps as many as one half, of all cardiovascular deaths. In spite of its importance, only about one half of those with the disease ordinarily are detected, only one half of those found to be hypertensive are being treated, and, of those who are receiving treatment, only one half, that is one eighth of the total hypertensive population, are receiving adequate treatment. Essential hypertension has been considered to be a disease of adults. The information available to physicians about its mechanisms, its endpoints, and its therapy has been developed from data collected in adult populations.

2001 ◽  
Vol 12 (3) ◽  
pp. 606-615
Author(s):  
JEAN-MARC LALOUEL ◽  
ANDREAS ROHRWASSER ◽  
DANIEL TERREROS ◽  
TERRY MORGAN ◽  
KENNETH WARD

Abstract. There is general consensus that genetic variation accounts in part for individual susceptibilities to essential hypertension. In marked contrast to classic mendelian disorders, in which genetic alterations produce a gain or loss of function, genetic determinants of essential hypertension, high blood pressure of unknown cause, are expected to be small, achieving significance through the cumulative effects of environmental exposure over the course of a lifetime. Whether and how genetic factors that contribute to common diseases can be identified remain unclear. Research on a link between angiotensinogen and essential hypertension illustrates a path that began in genetics and is now leading toward nephrology. Various challenges encountered along the way may prove to be characteristic features of genetic investigations of the pathogenesis of common diseases. The implication of a gene by statistical analysis is only the beginning of a protracted process of functional analysis at increasing levels of biologic integration. The ultimate goal is to develop an understanding of the manner in which genetic variation at a locus can affect a physiologic parameter and to extract from this inference new knowledge of significance for the prevention or treatment of disease.


2008 ◽  
Vol 7 ◽  
pp. 76-76
Author(s):  
D PHELAN ◽  
C WATSON ◽  
R MARTOS ◽  
P COLLIER ◽  
M LEDWIDGE ◽  
...  

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