THOMAS WILLIS ON THE TREATMENT OF CHILDHOOD EPILEPSY (1667)

PEDIATRICS ◽  
1978 ◽  
Vol 61 (1) ◽  
pp. 72-72
Author(s):  
T. E. C.

Although Thomas Willis (1621-1675) was not specially devoted to diseases of children, his writings occasionally contained items relating to this subject that were sufficiently important to be quoted by subsequent writers on pediatrics. This is how Willis viewed the preventive and therapeutic management of epilepsy. A Man in this Neighborhood, had all his Children dead of Convulsions, within three months after they were born. At length, to prevent the same Fate in a Son of his that was new-born, he thought proper to try the Power of Medicine. I was called to him a few days after the Birth, and ordered an Issue in the first Place to be made in his Neck, and that two Ounces of Blood should be drawn next Day at the Neck, by the Application of Leeches. I advised besides, that for three Days before each Change of the Moon, and again before the Full, about five Grains of the following Powder should be given him Morning and Evening in a Spoonful of the Julap. Take prepared Human Skull, the Root of Male-Peony, of each one Drachm. Pearls in Powder, half a Drachm. Mix them all together, and make a very fine Powder. Take of Black Cherry-Water, three Ounces. The Antepileptick Water of Langius, and Ounce. Syrup of the Flowers of Male-Peony, six Drachms. I likewise ordered the Nurse to take a Draught of Whey, in which the Roots and Seeds of Male-Peony, and the Leaves of Lilly of the Valley had been boiled, twice every Day at the same Hours.

The distance between a laser transmitter on Earth and corner reflectors in space can now be measured with a precision of a few centimetres. The main theme of the meeting is the exploitation of such measurements between stations on Earth and reflectors embedded in artificial satellites or placed on the Moon. This Prologue prepares the way for the more specialized papers by reviewing the advances already made in geodesy and geophysics using less accurate observations of artificial satellites, and by briefly outlining previous lunar dynamical studies.


On a representation made by the author of the advantages which would result from a series of simultaneous observations of the tides, continued for a fortnight, along a great extent of coast, orders were given for carrying this measure into effect at all the stations of the Preventive service on the coasts of England, Scotland, and Ireland, from the 7th to the 22nd of June inclusive. From an examination of the registers of these observations, which were transmitted to the Admiralty, but part of which only have as yet been reduced, the author has been enabled to deduce many important inferences. He finds, in the first place, that the tides in question are not affected by any general irregularity, having its origin in a distant source, but only by such causes as are merely local, and that therefore the tides admit of exact determination, with the aid of local meteorological corrections. The curves expressing the times of high water, with relation to those of the moon’s transit, present a very satisfactory agreement with theory; the ordinates having, for a space corresponding to a fortnight, a minimum and maximum magnitude, though not symmetrical in their curvatures on the two sides of these extreme magnitudes. The amount of flexure is not the same at different places; thus confirming the result already obtained by the comparison of previous observations, and especially those made at Brest; and demonstrating the futility of all attempts to deduce the mass of the moon from the phenomena of the tides, or to correct the tables of the tides by means of the mass of the moon. By the introduction of a local, in addition to the general, semimenstrual inequality, we may succeed in reconciling the discrepancies of the curve which represents this inequality for different places; discrepancies which have hitherto been a source of much perplexity. These differences in the semimenstrual inequality are shown by the author to be consequences of peculiar local circumstances, such as the particular form of the coast, the distance which the tide wave has travelled over, and the meeting of tides proceeding in different directions; and he traces the influence of each of these several causes in producing these differences. A diurnal difference in the height of the tides manifests itself with remarkable constancy along a large portion of the coast under consideration. The tide hour appears to vary rapidly in rounding the main promontories of the coast, and very slowly in passing along the shores of the intervening bays; so that the cotidal lines are brought close together in the former cases, and, in the latter, run along nearly parallel to the shore; circumstances which will also account for comparative differences of level, and of corresponding velocities in the tide stream. The author intends to prosecute the subject when the whole of the returns of these observations shall have undergone reduction.


Behaviour ◽  
1966 ◽  
Vol 26 (1-2) ◽  
pp. 105-123 ◽  
Author(s):  
Hobart F. Landreth ◽  
Denzel E. Ferguson

AbstractYoung Fowler's toads from on and near the shores of a lake were tested in a circular pen 60 feet in diameter. Under a variety of conditions (e.g. including group tests, individual tests, simultaneous testing of two groups from different shores, long distance displacement, and transit to the test pen both in view of the sky and in lightproof containers), the toads oriented under the sun to a compass direction (Y-axis) corresponding to a line bisecting the home shoreline at right angles. This orientation persisted after 72 hours in darkness, indicating the existence of an internal clock mechanism. Reorientation to a new shore was evident in 24 hours and was virtually complete after 48 hours. Orientation failed or was partially inhibited in small toads tested under dense cloud cover, at noon, and after sunset. Also, the type of orientation exhibited under the sun was evident at night under the moon, but to a lesser extent under starry skies. These mechanisms are useful in foraging and in dispersal from nursery shores. Adults are oriented at night to the breeding site even without benefit of a chorus for reference. Adults oriented to the Y-axis of the breeding site. A recorded chorus distracted migrating adults pursuing a compass course toward a pond. Non-breeding adults compensated for a displacement made in view of the sun. Celestial orientation is considered a basic orientational mechanism which most likely developed early in anuran history.


1761 ◽  
Vol 52 ◽  
pp. 21-25 ◽  

Dr. Watson lately received a letter from the Abbé De la Caille at Paris, in which he takes notice, "That although the pa- "rallax of the moon seems sufficiently well deter"mined, by the observations made in 1751, in "Europe and at the Cape of Good Hope; never- "theless, an element of this importance cannot be “too well ascertained.


The table given in this paper contains the results of calculations relating to the objects specified in the title; cast into periods of six, seven, or eight days, so as to bring the day of the lunar phase belonging to it in the middle of the time. The observations were all made in the neighbourhood of London. It appears from them that in the period of the last quarter of the moon the barometer is highest, the temperature a little above the mean, and the depth of rain the smallest. In the period of the new moon, both the barometer and temperature are considerably depressed, and the rain increased in quantity. The influence of the first quarter shows itself by the further depression of the barometer; but the temperature rises almost to the point from which it had fallen, and the rain still increases, but not in an equal ratio. Lastly, the full moon again reduces the temperature; while the barometer attains its maximum mean height, and the quantity of rain is the greatest. Thus it appears, that during this lunar cycle, the approach of the last quarter is the signal for the clearing up of the air, and the return of sunshine.


2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Hoang Quan Nguyen ◽  
Ngoc Trinh Thi Pham ◽  
Van Trung Hoang ◽  
Hoang Anh Thi Van ◽  
Chinh Huynh ◽  
...  

Pancreatic cancer is one of the seven leading causes of cancer death worldwide. Diffuse pancreatic carcinoma is very rare and underreported in the literature. Many advances have been made in the diagnosis and management of pancreatic cancer. However, most pancreatic cancer cases are detected at the terminal or metastatic stages. Therefore, timely diagnosis and therapeutic management are desirable goals for this disease. Although the proliferation of pancreatic cancer has been reduced by intervention, more work is needed to treat and prevent the disease. The purpose of this article is to present a case of a 54-year-old male with pancreatic cancer and to review the epidemiology, diagnosis, management, and prevention of pancreatic tumors in general as well as pancreatic carcinoma in particular.


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