Rubella Immunization: Present Status and Future Perspectives
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Sixteen years have elapsed since the last major epidemic of rubella in the United States. Prior to 1964, extensive outbreaks occurred at about six- to nine-year intervals. These outbreaks were associated with the birth of many thousands of infants with one or more of the following defects: cataracts, deafness, cardiac malformations, and brain damage causing mental retardation, cerebral palsy, or severe behavior disorders. In addition, many pregnancies were terminated by spontaneous or therapeutic abortions. This devastating "rubella problem" provided the motivation for the development of rubella vaccine. The live attenuated rubella vaccine was licensed for use in 1969—two to four years before the next anticipated epidemic.
1991 ◽
Vol 8
(1)
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pp. 43-56
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1966 ◽
Vol 56
(4)
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pp. 623-625
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1898 ◽
Vol 46
(1180supp)
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pp. 18920-18921
1998 ◽
Vol 27
(1)
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pp. 84-96
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