Effect of Iron Therapy on Behavior Performance in Nonanemic, Iron-Deficient Infants

PEDIATRICS ◽  
1983 ◽  
Vol 71 (6) ◽  
pp. 877-880 ◽  
Author(s):  
Frank A. Oski ◽  
Alice S. Honig ◽  
Brenda Helu ◽  
Peter Howanitz
Keyword(s):  
Iron Deficiency ◽  
Mental Development ◽  
Mean Cell Volume ◽  
Ferritin Concentration ◽  
Development Index ◽  
Biochemical Alterations ◽  
Mental Development Index ◽  
Iron Deficient ◽  
Serum Ferritin Concentration ◽  
Parenteral Iron

In an effort to determine whether iron deficiency, in the absence of anemia (hemoglobin >11.0 g/dL), might produce alterations in behavioral development, four groups of nonanemic infants, 9 to 12 months of age, with varying degrees of iron deficiency were studied. Infants were classified as iron sufficient, iron depleted, or iron deficient based on measurements of serum ferritin concentration, erythrocyte protoporphyrin values, and the mean cell volume of erythrocytes. Subjects in each group were tested with the Bayley Mental Development Index, treated with parenteral iron, and retested seven days later. The administration of iron produced a significant increase in the Mental Development Index scores (+21.6 points) in the infants with iron deficiency but no significant change in the scores of infants with iron sufficiency (+6.2 points) or only iron depletion (+5.6 points). It is concluded that iron deficiency, even in the absence of anemia, results in biochemical alterations that impair behavior in infants.

scholarly journals Zinc protoporphyrin as screening test in female blood donors

1998 ◽  
Vol 44 (4) ◽  
pp. 800-804 ◽  
Author(s):  
Else J Harthoorn-Lasthuizen ◽  
Jan Lindemans ◽  
Mart M A C Langenhuijsen
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Blood Donors ◽  
Deficiency Anemia ◽  
Zinc Protoporphyrin ◽  
Ferritin Concentration ◽  
Iron Deficient ◽  
Serum Ferritin Concentration ◽  
Low Serum

Abstract Erythrocyte zinc protoporphyrin (ZPP) was measured in 102 women blood donors to evaluate its usefulness in screening for evolving iron deficiency anemia, a reason for the deferral of donors. The results were compared with serum ferritin determinations. Five women were deferred before their first donation and eight women were deferred after one or two donations. Women with increased ZPP values all had low serum ferritin concentrations, indicating iron-deficient erythropoiesis that was caused by iron depletion. The positive predictive value of an increased ZPP in predicting deferral of the donor after one or two donations was 75%, whereas a serum ferritin concentration ≤12 μg/L predicted deferral in 26% of the donors. The results indicate that the ZPP test can be recommended as a feasible and inexpensive predonation test to determine a subset of donors with iron-deficient erythropoiesis at risk of developing iron deficiency anemia.

Micropremies

PEDIATRICS ◽  
1992 ◽  
Vol 89 (1) ◽  
pp. 167-167
Author(s):  
HARLEY G. GINSBERG
Keyword(s):  
Birth Weight ◽  
Neurodevelopmental Outcome ◽  
Mental Development ◽  
Female Infant ◽  
Developmental Assessment ◽  
Development Index ◽  
Mental Development Index ◽  
Developmental Index

To the Editor.— We read with great interest the editorial submitted by Drs Moro and Minoli describing the neurodevelopmental outcome of an infant who was delivered at 27 weeks gestation with a birth weight of 450 g.1 We were disappointed, however, that they overlooked our recent report of a 380-g female infant who was delivered at 25 3/7 weeks gestation.2 Our infant, Monica, is developing normally after a 122-day hospitalization. Her 20-month Bayley developmental assessment revealed a mental development index of 69 (102 when corrected for prematurity), and psychomotor developmental index of 97 (122 when corrected for prematurity).

Iron deficiency

2011 ◽  
Author(s):  
R. Mark Beattie ◽  
Anil Dhawan ◽  
John W.L. Puntis
Keyword(s):  
Iron Deficiency ◽  
Inner City ◽  
Blood Film ◽  
Mean Cell Volume ◽  
Excess Iron ◽  
Iron Deficient ◽  
The World ◽  
The Usa ◽  
Normal Mean ◽  
Cell Breakdown

Diagnosis 54Management 55Iron deficiency is the most common nutritional deficiency in the world, affecting around 5 billion people, most of them from developing countries. The prevalence of iron deficiency anaemia in UK preschool children is ~8%, increasing considerably in inner city children; ~9% of under 5s in the USA are thought to be iron deficient. Depletion of iron stores is followed by the development of anaemia, initially with a normal mean cell volume (MCV). Continuing deficiency leads to impairment of erythropoiesis, with hypochromia and microcytosis apparent on blood film. Iron is essential in haemoglobin for oxygen transport, and is also found in myoglobin, and some enzymes (peroxidase, catalase, and cytochromes). Iron from red blood cell breakdown is recycled and excess iron stored as ferritin and haemosiderin....

Correlation between Diagnostic 59Fe2+-Absorption and Serum Ferritin Concentration in Man

1977 ◽  
Vol 32 (11-12) ◽  
pp. 1023-1025 ◽  
Author(s):  
H. C. Heinrich ◽  
J. Brüggemann ◽  
E. E. Gabbe ◽  
M. Gläser ◽  
Fatima Icagic ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Correlation Coefficient ◽  
Serum Ferritin ◽  
Inverse Relationship ◽  
Sensitive Indicator ◽  
Ferritin Concentration ◽  
Iron Stores ◽  
Serum Ferritin Concentration ◽  
The Relationship

Abstract A high correlation coefficient r = -0.832 (Pr≠0 <0.0001) was estimated in man for the inverse relationship between the diagnostic 59Fe2+-absorption and the serum ferritin concentration which is very close to the correlation r = - 0.88 as described for the relationship between the diagnostic 59Fe2+-absorption and the diffuse cytoplasmic storage iron in the bone marrow macrophages. The increase of the diagnostic 59Fe2+-absorption seems to be an earlier and more sensitive indicator of depleted iron stores whereas the serum ferritin decreases somewhat later during the development of iron deficiency.

Hematologic Features of Iron Deficiency Anemia in Llamas

1992 ◽  
Vol 29 (5) ◽  
pp. 400-404 ◽  
Author(s):  
D. E. Morin ◽  
F. B. Garry ◽  
M. G. Weiser ◽  
M. J. Fettman ◽  
L. W. Johnson
Keyword(s):  
Iron Deficiency ◽  
Cell Volume ◽  
Iron Deficiency Anemia ◽  
Hemoglobin Concentration ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Mean Corpuscular Hemoglobin ◽  
Volume Distribution ◽  
Mean Cell Volume ◽  
Parenteral Iron

Iron deficiency anemia was identified and characterized in three 14 to 29-month-old male llamas (llama Nos. 1–3) from separate herds in Colorado. The identification of iron deficiency anemia was based on hypoferremia (serum iron = 20–60 μg/dl), erythrocytic features, and hematologic response to iron therapy. The anemia was moderate and nonregenerative and characterized by erythrocyte hypochromia, microcytosis (mean cell volume = 15–18 fl), and decreased mean corpuscular hemoglobin concentration (36.0–41.0 g/dl). Morphologic features unique to llamas with iron deficiency anemia included irregular distribution of hypochromia within erythrocytes and increased folded cells and dacryocytes. The cause of iron deficiency was not determined. The llamas were treated with various doses and schedules of parenteral iron dextran. Two of the llamas were monitored for up to 14 months after the start of iron therapy and experienced increases in hematocrit and mean cell volume values. In one llama, progressive replacement of microcytic cells with normal cells was visualized on sequential erythrocyte volume distribution histograms following iron therapy.

scholarly journals Enzyme-linked Immunosorbent Assay to Measure Serum Ferritin and the Relationship between Serum Ferritin and Nonheme Iron Stores in Cats

1994 ◽  
Vol 31 (6) ◽  
pp. 674-678 ◽  
Author(s):  
G. A. Andrews ◽  
P. S. Chavey ◽  
J. E. Smith
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Immunosorbent Assay ◽  
Serum Iron ◽  
Nonheme Iron ◽  
Enzyme Linked Immunosorbent Assay ◽  
Ferritin Concentration ◽  
Iron Stores ◽  
Tissue Iron ◽  
Serum Ferritin Concentration

Serum ferritin concentration correlates with tissue iron stores in humans, horses, calves, dogs, and pigs but not in rats. Because serum iron and total iron-binding capacity can be affected by disorders unrelated to iron adequacy (such as hypoproteinemia, chronic infection, hemolytic anemia, hypothyroidism, and renal disease), serum ferritin is probably the most reliable indicator of total body iron stores in larger species. To test the hypothesis that serum ferritin might be correlated with tissue iron levels in cats, we developed a quantitative enzyme-linked immunosorbent assay that uses two monoclonal antibodies in a sandwich arrangement to measure feline serum ferritin. The recovery of purified ferritin added to feline sera ranged from 94% to 104%; the within-assay coefficient of variability was 8.4%, and the assay-to-assay variability was 13.2%. Mean serum ferritin from 40 apparently healthy cats was 76 ng ml (SD = 24 ng/ml). Serum ferritin concentration was significantly correlated ( P < 0.001, n = 101, r = 0.365) with the nonheme iron in the liver and spleen (expressed as milligrams of iron per kilogram of body weight), as determined by Pearson product-moment correlation analysis. Because serum iron can decrease in diseases other than iron deficiency, the combination of serum iron and serum ferritin should provide sufficient evidence to differentiate anemia of chronic inflammation from anemia of iron deficiency in the cat.

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