Gastroesophageal Reflux Associated With Nemaline Myopathy of Infancy

PEDIATRICS ◽  
1988 ◽  
Vol 81 (1) ◽  
pp. 111-115
Author(s):  
Stuart Berezin ◽  
Leonard J. Newman ◽  
Steven M. Schwarz ◽  
Alfred J. Spiro
Keyword(s):  
Gastroesophageal Reflux ◽  
Medical Therapy ◽  
Ph Monitoring ◽  
Nemaline Myopathy ◽  
Severe Form ◽  
Persistent Vomiting ◽  
Esophageal Ph ◽  
Life Threatening ◽  
Esophageal Sphincter ◽  
Low Amplitude

A severe infantile form of nemaline myopathy has a high mortality rate when untreated because of subsequent malnutrition and respiratory failure. Three infants with this condition demonstrated persistent vomiting, poor weight gain, and recurrent pneumonias. Esophageal manometry demonstrated decreased lower esophageal sphincter pressures and low amplitude peristalsis; 24-hour esophageal pH monitoring revealed significant gastroesophageal reflux. Medical therapy was ineffective in relieving symptoms. After antireflux surgery, vomiting and respiratory symptoms ceased, and there was no longer significant gastroesophageal reflux during pH monitoring. Our experience indicates that in some infants with nemaline myopathy a severe form of gastroesophageal reflux develops that is not responsive to medical therapy. Early surgical intervention may decrease life-threatening complications associated with gastroesophageal reflux in these infants.

BRAVO esophageal pH monitoring: more cost-effective than empiric medical therapy for suspected gastroesophageal reflux

2015 ◽  
Vol 30 (8) ◽  
pp. 3454-3460 ◽  
Author(s):  
Cheguevara Afaneh ◽  
Veronica Zoghbi ◽  
Brendan M. Finnerty ◽  
Anna Aronova ◽  
David Kleiman ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Medical Therapy ◽  
Ph Monitoring ◽  
Cost Effective ◽  
Esophageal Ph Monitoring ◽  
Esophageal Ph

Positioning of the pH-probe by manometry or radiography for monitoring of the esophagus: Influence on diagnostic results?

2003 ◽  
Vol 44 (4) ◽  
pp. 360-362
Author(s):  
K. Aksglæde ◽  
P. Thommesen
Keyword(s):  
Gastroesophageal Reflux ◽  
Lower Esophageal Sphincter ◽  
Ph Monitoring ◽  
Gastroesophageal Junction ◽  
Ph Probe ◽  
Rye Bread ◽  
Esophageal Ph ◽  
Significant Difference ◽  
Oblique Position ◽  
Esophageal Sphincter

Purpose: To correlate gastroesophageal reflux (GER), demonstrated by radiography using bread and barium, with 24-h pH monitoring in the esophagus, with the pH-probe positioned by manometry or radiology. Material and Methods: In all, 146 patients, 41 females and 105 males, with a median age of 47 years, suspected of GER were examined. Radiography was performed with the patient in the supine right oblique position during mastication and swallowing a piece of rye bread with liver pâté and barium. The test was positive if barium was observed more than 5 cm proximal to the gastroesophageal junction (GEJ). An antimony pH-probe was placed 5 cm above the lower esophageal sphincter determined by manometry, or 5 cm above the GEJ determined by radiography. The total time of esophageal pH < 4 exceeding 5% was considered pathological. Results: The radiological method had a specificity of 100% and a sensitivity of 52% compared to 24-h pH monitoring with the pH-probe positioned manometrically, and a specificity of 100% and sensitivity of 67% with the pH-probe positioned by radiography, with no significant difference between the two positionings. Conclusion: In 146 patients submitted to 24-h pH monitoring, the pH-probe could be placed as safely by radiography as by manometry.

Prospective Study on the Incidence of Chronic Ear Complaints Related to Gastroesophageal Reflux and on the Outcome of Antireflux Therapy

2002 ◽  
Vol 111 (10) ◽  
pp. 933-938 ◽  
Author(s):  
Johan Poelmans ◽  
Jan Tack ◽  
Louw Feenstra
Keyword(s):  
Gastroesophageal Reflux ◽  
Ph Monitoring ◽  
Upper Gastrointestinal Endoscopy ◽  
Esophageal Ph ◽  
Tube Dysfunction ◽  
Esophageal Sphincter ◽  
Antireflux Therapy ◽  
Dual Probe ◽  
Upper Gastrointestinal

Over a 2-year period (1997 to 1999), 5 consecutive adult patients with chronic refractory secretory otitis media (CSOM) and 16 with a chronic refractory feeling of pressure in the ear(s) (CRFP) thought to be related to concomitant eustachian tube dysfunction were prospectively studied for coexisting gastroesophageal reflux (GER). All patients underwent an extensive standardized otorhinolaryngological examination, ambulatory 24-hour dual-probe esophageal pH monitoring with a distal pH probe 5 cm and a proximal probe 20 cm above the lower esophageal sphincter, and upper gastrointestinal endoscopy. Most of them also underwent esophageal manometry. All patients with CSOM and 12 of the 16 patients with CRFP had evidence of GER. Only 5 patients experienced heartburn or regurgitation. All patients responded very well to antireflux therapy with omeprazole 20 mg twice per day (40 mg twice per day in 2 patients) accompanied by conservative antireflux measures, ie, complete cessation of their middle ear complaints. This study demonstrates the role of GER in the pathogenesis of refractory CSOM and CRFP and the effectiveness of sustained antireflux therapy.

Characteristics of Continuous Esophageal pH-Metering in Infants with Gastroesophageal Reflux and Apparent Life-Threatening Events

1995 ◽  
Vol 5 (03) ◽  
pp. 136-138 ◽  
Author(s):  
P. Gorrotxategi ◽  
I. Eizaguirre ◽  
A. Saenz de Ugarte ◽  
M. Reguilon ◽  
J. Emparanza ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Esophageal Ph ◽  
Life Threatening

scholarly journals Associations of Obstructive Sleep Apnea, Obestatin, Leptin, and Ghrelin with Gastroesophageal Reflux

2021 ◽  
Vol 10 (21) ◽  
pp. 5195
Author(s):  
Piotr Pardak ◽  
Rafał Filip ◽  
Jarosław Woliński ◽  
Maciej Krzaczek
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Gastroesophageal Reflux ◽  
Ph Monitoring ◽  
Sleep Study ◽  
Esophageal Ph ◽  
Obstructive Sleep ◽  
The Relationship ◽  
Gerd Symptoms ◽  
Severe Sleep Apnea

Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep apnea (OSA). Hormonal disorders observed in OSA may be relevant in the development of GERD. The aim of the study was to assess the correlations between ghrelin, obestatin, leptin, and the intensity of GERD in patients with OSA. The study included 58 patients hospitalized due to clinical suspicion of sleep disorders during sleep. All patients underwent a sleep study, and blood samples were collected overnight for hormonal tests. Survey data concerning symptoms of GERD, gastroscopy, and esophageal pH monitoring results were included in the study. In patients with OSA, GERD was twice as common when compared to the group without OSA. Among subjects with severe sleep apnea (AHI > 30; n = 31; 53%), we observed lower ghrelin levels, especially in the second half of the night and in the morning (p5.00 = 0.0207; p7.00 = 0.0344); the presence of OSA had no effect on obestatin and leptin levels. No significant differences in hormonal levels were observed between the groups depending on the diagnosis of GERD. However, correlations of ghrelin levels with the severity of esophagitis, leptin and ghrelin levels with the severity of GERD symptoms, and leptin levels with lower esophageal pH were found. GERD is more frequent among patients with OSA. In both GERD and OSA, deviations were observed in the levels of ghrelin and leptin. However, our analysis demonstrates that the relationship between OSA and GERD does not result from these disorders.

scholarly journals Gastroesophageal Reflux and Wheezing in Pediatry pH-metry studies

2019 ◽  
Vol 70 (7) ◽  
pp. 2668-2670
Author(s):  
Alina Mihaela Elisei ◽  
Dana Tutunaru ◽  
Camelia Ana Grigore ◽  
Ciprian Adrian Dinu ◽  
Laura Florescu ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Pediatric Practice ◽  
First Semester ◽  
Esophageal Ph ◽  
Esophageal Sphincter ◽  
Specific Symptoms ◽  
Acidity Level ◽  
Ph Metry

Analysis of esophageal pH is useful and recommended by specialists when the gastroesophageal reflux disease does not show specific symptoms such as chest pain or burnings, but a form of asthma and chronic cough. The investigation is performed after a mild anesthesia, inserting a thin and flexible catheter in the patient�s nostril; it reaches the esophagus, particularly the esophageal sphincter that connects the stomach to the esophagus. The catheter has a sensor that monitors the acidity level, the number of reflux episodes, their duration and the part of the esophagus reached by the acid in the stomach. Gastroesophageal reflux disease is frequently met in pediatric practice, rooting in the intrauterine life, a physiologic phenomenon in infants during the first semester of life.

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